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Image Unavailable-100243-016

Anti-CD44 Rat Monoclonal Antibody (APC (Allophycocyanin)) [clone: KM201]

Catalog Number: (100243-016)
Supplier: Southern Biotechnology
Description: CD44 represents a family of type I transmembrane glycoproteins expressed on many cell types such as B cells, monocytes, macrophages, and variable subsets of thymocytes and peripheral T cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes, such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis and development. The KM201 monoclonal antibody reacts with an epitope very close to the hyaluronate binding domain on the CD44 molecule. KM201 can inhibit hyaluronate-dependent cell aggregation, prevent lympho-hemopoiesis in both Dexter and Whitlock-Witte cultures, prevent the earliest intrathymic precursors from homing to the thymus, and costimulate the activation of freshly purified splenic CD4+ T cells.
Image Unavailable-100243-858

Anti-NK1.1 Mouse Monoclonal Antibody [clone: PK136]

Catalog Number: (100243-858)
Supplier: Southern Biotechnology
Description: NK1.1, a member of the NKR-P1 family of cell surface receptors, is a type II integral membrane glycoprotein with a C-type lectin domain. It is expressed as a disulfide-linked homodimer on all NK cells as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g., C57BL/6, NZB, and CE). NK1.1 mediates cellular activation and differentiation, and is thought to have a particular role in generating Th2 cells. This product does not react with NK cells of BALB/c mice.
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Anti-CD45.1 Mouse Monoclonal Antibody (RPE (R-Phycoerythrin)/Cy5.5®) [clone: A20]

Catalog Number: (100243-806)
Supplier: Southern Biotechnology
Description: The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosphorylate the Src family of protein kinases. This activity is now known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685, and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2). The former arises as a result of alternative splicing of different exons. The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody A20 recognizes all mouse leukocytes expressing the CD45.1 allotype.
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Anti-CD45.2 Mouse Monoclonal Antibody (Alexa Fluor® 700) [clone: 104]

Catalog Number: (103264-638)
Supplier: Southern Biotechnology
Description: The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosporylate the Src family of protein kinases. This activity is known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685 and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2). The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody 104 recognizes CD45 (leukocyte common antigen) on all leukocytes of mouse strains expressing the CD45.2 allotype (e.g., A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129).
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Anti-IgG (H+L) Goat Antibody (HRP (Horseradish Peroxidase))

Catalog Number: (100244-964)
Supplier: Southern Biotechnology
Description: Goat Anti-Bovine IgG(H+L)-HRP antibody for use in ELISA, immunocytochemistry and western blotting assays.
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Anti-IgG (H+L) Rabbit Antibody

Catalog Number: (100245-172)
Supplier: Southern Biotechnology
Description: Purified Rabbit Anti-Mouse IgG(H+L) antibody with minimal reactivity to human proteins for use in ELISA, flow cytometry, immunocytochemistry, and western blotting assays.
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Anti-IgG F(c) Goat Antibody

Catalog Number: (103260-042)
Supplier: Southern Biotechnology
Description: Purified Goat Anti-Human IgG Fc antibody with minimal reactivity to mouse, bovine, and horse serum proteins for use in ELISA assays.
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Anti-TCRbeta Hamster Monoclonal Antibody (Pacific Blue™) [clone: H57-597]

Catalog Number: (103264-622)
Supplier: Southern Biotechnology
Description: The αβ TCR is expressed on T lymphocytes of all mouse strains tested. The H57-597 monoclonal antibody does not react with γδ TCR-bearing cells. Plate-bound or soluble H57-597 activates αβ TCR-bearing T cells. In vitro and in vivo, H57-597 can induce immature thymocytes to undergo apoptosis. In vivo administration of H57-597 has been shown to deplete αβ TCR-bearing cells to near completion and prevent graft rejection.
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Anti-IgG (H+L) Rabbit Antibody

Catalog Number: (100244-942)
Supplier: Southern Biotechnology
Description: Purified Rabbit F(ab')2 Anti-Goat IgG(H+L) antibody for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.
Image Unavailable-103264-518

Anti-Type I Collagen Mouse Monoclonal Antibody (HRP (Horseradish Peroxidase)) [clone: 4F6]

Catalog Number: (103264-518)
Supplier: Southern Biotechnology
Description: HRP Anti-Human Type I Collagen antibody for use in ELISA and immunohistochemistry assays.
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Rat IgG Isotype Control

Catalog Number: (100242-012)
Supplier: Southern Biotechnology
Description: Low Endotoxin/Azide Free Rat IgG for use as a control in flow cytometry, immunohistochemistry / immunocytochemistry, and in vivo assays and as a standard in ELISA.
Image Unavailable-100241-948

Mouse IgG2b Isotype Control [clone: A-1] (RPE (R-Phycoerythrin)/Cy7®)

Catalog Number: (100241-948)
Supplier: Southern Biotechnology
Description: Mouse IgG2b-PE/CY7 for use as a control in flow cytometry assays.
Image Unavailable-103259-902

Anti-CD11b Rat Monoclonal Antibody (Alexa Fluor® 700) [clone: M1/70]

Catalog Number: (103259-902)
Supplier: Southern Biotechnology
Description: CD11b, the integrin αM subunit, combines with CD18, the integrin β2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.
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Anti-CD62L Rat Monoclonal Antibody (RPE (R-Phycoerythrin)/Cy7®) [clone: MEL-14]

Catalog Number: (100243-604)
Supplier: Southern Biotechnology
Description: CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.
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Anti-Kappa Goat Antibody (RPE (R-Phycoerythrin))

Catalog Number: (100244-360)
Supplier: Southern Biotechnology
Description: Goat F(ab')2 Anti-Human Kappa-PE antibody for use in flow cytometry assays.
Image Unavailable-100244-592

Anti-IgG1 Mouse Antibody (RPE (R-Phycoerythrin)) [clone: G11C5]

Catalog Number: (100244-592)
Supplier: Southern Biotechnology
Description: PE Anti-Rat IgG1 antibody for use in flow cytometry assays.
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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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