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Catalog Number: (100243-896)

Supplier: Southern Biotechnology

Description: The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.

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Catalog Number: (100245-760)

Supplier: Southern Biotechnology

Description: HRP Anti-Human IgA1 antibody for use in ELISA, immunohistochemistry / immunocytochemistry, western blotting, and ELISpot assays.

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Catalog Number: (103265-026)

Supplier: Southern Biotechnology

Description: Purified Donkey Anti-Mouse IgG(H+L) antibody for use in ELISA assays.

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Catalog Number: (100244-124)

Supplier: Southern Biotechnology

Description: The monoclonal antibody 15-5-5 reacts with the H-2Dk class I alloantigen. It cross-reacts with H-2Kd and with cells from mice with the H-2f haplotype. The antibody does not react with other (e.g., a, b, p, q, r, s) haplotypes.

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Catalog Number: (100242-046)

Supplier: Southern Biotechnology

Description: Rabbit F(ab’)2 IgG-FITC for use as a control in flow cytometry assays.

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Catalog Number: (100243-244)

Supplier: Southern Biotechnology

Description: CD11b, the integrin αM subunit, combines with CD18, the integrin β2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.

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Catalog Number: (100246-404)

Supplier: Southern Biotechnology

Description: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance.

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Catalog Number: (100245-822)

Supplier: Southern Biotechnology

Description: FITC Anti-Human IgG3 Hinge antibody for use in flow cytometry, immunohistochemistry, and western blotting assays.

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Catalog Number: (101442-890)

Supplier: Southern Biotechnology

Description: c-Kit is a 145 kDa transmembrane receptor-type protein tyrosine kinase encoded by the c-Kit proto-oncogene and is the receptor for stem cell factor (SCF). c-Kit acts to regulate a variety of biological responses including cell proliferation, apoptosis, chemotaxis, and adhesion. The amino acid sequence of chicken c-kit shows 63% identity to mouse c-Kit and exhibits similar expression patterns in RNA blot analysis suggesting similar biological roles.

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Catalog Number: (101190-236)

Supplier: Southern Biotechnology

Description: Low Endotoxin/Azide Free Anti-Mouse IL-17A antibody for use in flow cytometry, ELISA, ELISpot, and neutralization assays.

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Catalog Number: (100245-622)

Supplier: Southern Biotechnology

Description: In the chicken the CD8 molecule is present in two forms - (i) a homodimer of two α chains and (ii) a heterodimer of an α chain and a β chain. Chicken CD8 is expressed on approximately 80% of thymocytes, 45% of blood mononuclear cells, and 50% of spleen cells but less than 1% of cells in the bursa and bone marrow. While the vast majority of CD8+ cells in the thymus, spleen, and blood of adult chickens express both CD8α- and CD8β-chains, a relatively large proportion of the CD8+ TCRγδ cells in the spleens of embryos and young chicks express only the α-chain of CD8. Among intestinal epithelial lymphocytes, the major CD8+ T cell populations present in mice are conserved but there is a population of TCRγδ CD8αβ cells in the chicken that is not found in rodents. The monoclonal antibody 3-298 recognizes the CD8α chain of both the chicken and turkey.

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Catalog Number: (103259-738)

Supplier: Southern Biotechnology

Description: Hamster IgG-Pacific Blue for use as a control in flow cytometry assays.

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Catalog Number: (103259-984)

Supplier: Southern Biotechnology

Description: Goat Anti-Human IgG Fc-PE antibody for use in fluorescent assays.

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Catalog Number: (103264-508)

Supplier: Southern Biotechnology

Description: Biotin Anti-Mouse IgG2a antibody for use in ELISA, flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, and multiplex assays.

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Catalog Number: (100244-228)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Human IgM-FITC antibody for use in flow cytometry and immunocytochemistry assays.

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Catalog Number: (103260-204)

Supplier: Southern Biotechnology

Description: CD5, a member of the scavenger receptor superfamily of cell surface receptors, is a type I transmembrane glycoprotein whose ligand is CD72. It is expressed on most thymocytes, all mature T cells, and a subset of B cells. CD5 plays a role in regulation of T cell activation and signaling.

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