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Catalog Number: (100245-756)

Supplier: Southern Biotechnology

Description: FITC Anti-Human IgA1 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (103259-960)

Supplier: Southern Biotechnology

Description: NK1.1, a member of the NKR-P1 family of cell surface receptors, is a type II integral membrane glycoprotein with a C-type lectin domain. It is expressed as a disulfide-linked homodimer on all NK cells as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g., C57BL/6, NZB, and CE). NK1.1 mediates cellular activation and differentiation, and is thought to have a particular role in generating Th2 cells. This product does not react with NK cells of BALB/c mice.

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Supplier: Southern Biotechnology

Description: In the mouse, CD8 exists in two forms – (i) a CD8 heterodimer composed of an α chain (CD8α) and a β chain (CD8β); and (ii) a homodimer of two α chains. The heterodimer is found on the surface of essentially all thymocytes and the “suppressor/cytotoxic” subpopulation of mature T lymphocytes. Subsets of intestinal intraepithelial lymphocytes express CD8α without CD8β. It has been suggested that CD8+β- T cells mature extrathymically, while development of the CD8α+β+ population of T cells is thymus-dependent. CD8 acts as a coreceptor with MHC Class I-restricted T cell receptors in antigen recognition and positive selection of MHC class I-restricted CD8+ T cells. In vivo and in vitro treatment with the 53-6.7 monoclonal antibody effectively depletes CD8α+ cells. The 53-6.7 monoclonal antibody also blocks allogeneic help specific for class I MHC antigens and T cell responses to IL-2.

Catalog Number: (100244-352)

Supplier: Southern Biotechnology

Description: Purified Goat F(ab')2 Anti-Human Kappa antibody for use in ELISA, flow cytometry, immunocytochemistry, western blotting, and stimulation assays and for immobilization in surface plasmon resonance.

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Catalog Number: (103260-092)

Supplier: Southern Biotechnology

Description: Goat Anti-Rhesus IgG(H+L)-Biotin antibody for use in ELISA, immunocytochemistry, western blotting, and multiplex assays.

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Catalog Number: (103259-964)

Supplier: Southern Biotechnology

Description: NK1.1, a member of the NKR-P1 family of cell surface receptors, is a type II integral membrane glycoprotein with a C-type lectin domain. It is expressed as a disulfide-linked homodimer on all NK cells as well as subsets of thymocytes and peripheral T lymphocytes in selected strains of mice (e.g., C57BL/6, NZB, and CE). NK1.1 mediates cellular activation and differentiation, and is thought to have a particular role in generating Th2 cells. This product does not react with NK cells of BALB/c mice.

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Catalog Number: (103264-462)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG2a-Alexa Fluor 488 antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (100242-036)

Supplier: Southern Biotechnology

Description: Goat F(ab’)2 IgG-PE/CY5 (SPRD) for use as a control in flow cytometry assays.

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Supplier: Southern Biotechnology

Description: CD3, a member of the immunoglobulin superfamily of cell surface receptors, is comprised of five invariable chains ranging from 16-28 kDa and is closely associated with the T cell antigen receptor (TCR). CD3 is expressed on 70-80% of normal peripheral blood lymphocytes and on 10-20% of thymocytes. It plays a major role in signaling during antigen recognition, leading to T cell activation. The monoclonal antibody UCHT1 reacts with the 20 kDa ε chain of the CD3/TCR complex.

Catalog Number: (103264-688)

Supplier: Southern Biotechnology

Description: PE Anti-Hamster IgG2/IgG3 antibody for use in flow cytometry assays.

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Catalog Number: (101442-798)

Supplier: Southern Biotechnology

Description: The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.

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Catalog Number: (100244-014)

Supplier: Southern Biotechnology

Description: The monoclonal antibody NIMR-4 reacts specifically with a non-polymorphic I-A-encoded epitope on MHC Class II antigens. Class II antigens are predominantly expressed on antigen-presenting cells including B lymphocytes, macrophages, dendritic cells, and certain epithelial cells.

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Catalog Number: (100242-714)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG2b-Texas Red antibody with minimal reactivity to human proteins for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (100245-678)

Supplier: Southern Biotechnology

Description: Biotin Anti-Human IgD antibody for use in ELISA, flow cytometry, immunohistochemistry, immunoprecipitation, and separation assays.

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Catalog Number: (100244-798)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Rabbit IgG(H+L)-PE antibody with minimal reactivity to mouse and human proteins for use in flow cytometry assays.

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Catalog Number: (100245-570)

Supplier: Southern Biotechnology

Description: Chicken Bu-1a, a product of the Bu-1a allele, is expressed on the cell surface as a disulfide-linked homodimer. In 10-week-old H.B15 and H.B2 chickens, Bu-1 is found on 85-90% of bursal cells, 2-8% of thymocytes, 15-27% of spleen cells, and 2-18% of peripheral blood cells. It is also expressed on subsets of macrophages and monocytes but not on granulocytes, erythrocytes, or thrombocytes. In chickens heterozygous for the Bu-1 alleles (Bu-1a/b), Bu-1a does not exhibit allelic exclusion. The monoclonal antibody 21-1A4 does not react with cells from CHA and H.B14ab strains by immunofluorescence.

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