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Description: CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.
Catalog Number: 100243-302
Supplier: Southern Biotechnology


Description: CD4 is a type I transmembrane glycoprotein expressed on approximately 70% of thymocytes, 10% of spleen cells, and 45% of peripheral blood lymphocytes but less than 1% of bursal cells.
Catalog Number: 100245-460
Supplier: Southern Biotechnology


Description: The monoclonal antibody DX5 reacts with CD49b, also known as very late antigen-2 (VLA-2) and α2 integrin. The antibody stains the majority of NK cells and a small subpopulation of T cells in all mouse strains tested (e.g., A/J, AKR, BALB/c, C3H/HeJ, C57BL/6, C57BL/10, C57BR, C58, CBA/Ca, CBA/J, DBA/1, DBA/2, SJL, SWR). Three-color flow cytometry analysis has revealed that most cells that express NK-1.1 (NKR-P1C) also express CD49b. However, small subsets of DX5+NK-1.1- and DX5-NK-1.1+ cells can be found, especially among the CD3+ population of T lymphocytes. NK cells cultured in the presence of IL-2 progressively lose reactivity with DX5 as a consequence of cellular proliferation. Therefore, DX5 can be used to define functionally distinct subsets of murine NK cells. The monoclonal antibody DX5 has not been demonstrated to have activating or blocking activity.
Catalog Number: 100243-878
Supplier: Southern Biotechnology


Description: Goat F(ab')2 Anti-Rat IgG-Texas Red antibody with minimal reactivity to mouse proteins for use in flow cytometry and immunohistochemistry assays.
Catalog Number: 100244-562
Supplier: Southern Biotechnology


Description: CD33 is a 67 kDa type I transmembrane glycoprotein and a member of the sialoadhesin family of cell surface receptors. It is absent from pluripotent stem cells but appears on myelomonocytic precursors after CD34. It then continues to be expressed on both the myeloid and monocyte lineages. While it has been reported that CD33 can function as a sialic acid-dependent cell adhesion molecule, cells expressing CD33 require desialylation before they can bind cells bearing the appropriate sialoglycoconjugates. This suggests that inhibitory cis interactions may regulate or block any adhesion function.
Catalog Number: 103265-390
Supplier: Southern Biotechnology


Description: Rabbit F(ab')2 Anti-Rat IgG(H+L)-AP antibody with minimal reactivity to human proteins for use in ELISA and immunocytochemistry assays.
Catalog Number: 100245-094
Supplier: Southern Biotechnology


Description: The 695H1-9-9 antibody reacts with a Qa-2-determined alloantigen. It recognizes an epitope distinct from that recognized by monoclonal antibody 1-1-2.
Catalog Number: 100244-084
Supplier: Southern Biotechnology


Description: CD11b (integrin αM subunit) combines with CD18 (integrin β2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.
Catalog Number: 100243-222
Supplier: Southern Biotechnology


Description: CD5, a member of the scavenger receptor superfamily of cell surface receptors, is a type I transmembrane glycoprotein whose ligand is CD72. It is expressed on most thymocytes, all mature T cells, and a subset of B cells. CD5 plays a role in regulation of T cell activation and signaling.
Catalog Number: 100246-074
Supplier: Southern Biotechnology


Description: CD45R, also known as B220, a member of the protein tyrosine phosphate family and a major cell surface glycoprotein, represents a restricted form of the CD45 family which primarily recognizes only cells of B-lineage from pro-B cell through mature B lymphocytes and prior to the availability of anti-CD19 monoclonal antibodies was commonly used as a pan B-cell marker. It also reacts with certain activated T cells as well as non-MHC-restricted lytically active lymphokine-activated killer (LAK) cells. In vivo administration of RA3-6B2 has been shown to affect differentiation of both T and B cells in normal mice and reduce the level of anti-DNA antibodies and lymphadenopathies in MRL/lpr mice.
Catalog Number: 100243-528
Supplier: Southern Biotechnology


Description: CD86 (B7-2) is an 80 kDa type I integral membrane protein and a member of the immunoglobulin superfamily of cell surface receptors. Along with CD80 (B7-1), CD86 participates in T cell costimulation via interaction with CD28 and CD152 (CTLA-4). It is expressed at very low density in normal tissues but is rapidly upregulated on stimulated B cells, monocytes, and dendritic cells. Since CD86 has rapid kinetics of induction, it is believed to be the major CD28 ligand expressed early in the immune response.
Catalog Number: 101442-808
Supplier: Southern Biotechnology


Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin. It is found in many simple and some non-keratinizing stratified squamous epithelia and is often co-expressed with keratin 7. Cytokeratin 19 has been implicated as a marker for stem cells in some tissues such as hair follicles in the skin. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers.
Catalog Number: 101442-588
Supplier: Southern Biotechnology


Description: Goat Anti-Guinea Pig IgG(H+L)-AP antibody for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.
Catalog Number: 100245-044
Supplier: Southern Biotechnology


Description: Rabbit Anti-Sheep IgG(H+L)-Biotin antibody with minimal reactivity to human serum proteins for use in ELISA, immunohistochemistry, and western blotting assays.
Catalog Number: 103264-982
Supplier: Southern Biotechnology


Description: Goat F(ab’)2 Anti-Mouse Ig-AP antibody with minimal reactivity to human proteins for use in ELISA, immunocytochemistry, western blotting, and ELISpot assays.
Catalog Number: 100242-322
Supplier: Southern Biotechnology


Description: FITC Anti-Rat IgM antibody for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.
Catalog Number: 100244-626
Supplier: Southern Biotechnology


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