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Catalog Number: (100243-250)
Supplier: Southern Biotechnology
Description: CD18 represents the common β2 integrin subunit that associates non-covalently with the α/β chains of CD11a, CD11b, and CD11c to form various integrin heterodimers. It is expressed strongly on lymphocytes and monocytes and weakly on granulocytes. CD18 mediates a variety of heterotypic and homotypic intercellular adhesion reactions and it regulates the ligand-binding activates of the various CD11/CD18 complexes. The monoclonal antibody C71/16 has not been reported to inhibit cell adhesion.


Catalog Number: (100243-994)
Supplier: Southern Biotechnology
Description: The CD117 (c-Kit) antigen is the cell-surface receptor for stem cell factor (SCF). Together these molecules constitute a ligand/receptor pair which functions to maintain normal hematopoiesis in the adult. Signaling through SCF/c-Kit has an important role in stimulating myeloid and erythroid production of primitive hematopoietic progenitor cells. A variety of cytokines act synergistically with SCF to stimulate proliferation and differentiation of bone marrow progenitor cells. For example, SCF plus IL-7 can stimulate the combined myeloid and B cell differentiation of uncommitted hematopoietic progenitor cells. SCF/c-Kit also participates in erythropoiesis in both the bone marrow and spleen. Loss-of-function mutations for SCF/c-Kit lead to a variety of pleiotropic developmental defects while gain-of-function mutations can lead to constitutive activation of the kit receptor and links to cancer. Examples of the former are mast cell deficiency and severe macrocytic anemia while the latter mutation has been identified in mastocytomas.


Catalog Number: (100245-076)
Supplier: Southern Biotechnology
Description: Rabbit F(ab')2 Anti-Mouse IgG(H+L)-AP antibody with minimal reactivity to human proteins for use in ELISA and immunohistochemistry assays.


Catalog Number: (103265-442)
Supplier: Southern Biotechnology
Description: CD107b, also known as lysosomal-associated membrane protein 2 (LAMP-2), is a heavily glycosylated type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains and is a ligand for E-selectin-mediated cell adhesion. CD107b is expressed in lysosomal/endosomal membranes and on the surface of activated platelets and some tumor cell lines including U937 and KG1a. LAMP-2 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential where they may increase adhesion to extracellular matrix and endothelium.


Catalog Number: (103259-786)
Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgG2a-AP antibody for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.


Catalog Number: (100243-588)
Supplier: Southern Biotechnology
Description: CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.


Catalog Number: (100245-116)
Supplier: Southern Biotechnology
Description: Rabbit Anti-Human IgG(H+L)-Biotin antibody with minimal reactivity to mouse proteins for use in ELISA and immunohistochemistry assays.


Catalog Number: (103260-116)
Supplier: Southern Biotechnology
Description: Purified Swine Anti-Rabbit IgG(H+L) antibody for use in ELISA assays.


Catalog Number: (100243-746)
Supplier: Southern Biotechnology
Description: The TCRγδ heterodimer of the CD3/T cell receptor complex is clonotypic and consists of Ig-like variable and constant domains. It is expressed during thymopoiesis and on the small subpopulation of γδ TCR-expressing T lymphocytes in the periphery. The majority of T cells present in some epithelial tissues are γδ+ and have limited receptor diversity. The TCRγδ heterodimer recognizes peptide antigen bound to MHC antigens and subsequent signal transduction mediated by the invariant chains leads to T cell activation. The monoclonal antibody UC7-13D5 is specific for the γδ heterodimer and plate-bound UC7-13D5 activates γδ TCR-bearing cells. This antibody does not react with αβ TCR-expressing T cells.


Catalog Number: (101442-502)
Supplier: Southern Biotechnology
Description: Mouse IgG1-APC/CY7 for use as a control in flow cytometry assays.


Catalog Number: (103264-494)
Supplier: Southern Biotechnology
Description: HRP Anti-Mouse IgG1 antibody for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.


Catalog Number: (100243-676)
Supplier: Southern Biotechnology
Description: CD90 (Thy-1), a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily of cell surface receptors, consists of a single V-set domain. It is expressed on thymocytes, peripheral T lymphocytes, some intraepithelial T lymphocytes, and neurons of all mouse strains. The monoclonal antibody G7 stimulates T-cell proliferation and IL-2 secretion via signaling through the T-cell receptor/CD3 complex. G7 has also been reported to promote apoptosis of thymocytes and CTL clones and to mediate adhesion of thymocytes to thymic stroma.


Catalog Number: (100242-700)
Supplier: Southern Biotechnology
Description: Goat F(ab’)2 Anti-Mouse IgG2a-Biotin antibody with minimal reactivity to human proteins for use in ELISA, flow cytometry, and immunohistochemistry / immunocytochemistry assays.


Catalog Number: (100242-406)
Supplier: Southern Biotechnology
Description: Purified Anti-Mouse IL-6 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, immunoprecipitation, ELISA, ELISpot, and multiplex assays.


Catalog Number: (100245-534)
Supplier: Southern Biotechnology
Description: Purified Anti-Chicken Lambda antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, and immunoprecipitation assays.


Catalog Number: (100242-762)
Supplier: Southern Biotechnology
Description: Purified Goat Anti-Mouse IgE antibody for use in ELISA, flow cytometry, immunocytochemistry, western blotting, and immunoprecipitation assays.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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