You Searched For: PEPROTECH INC.

Supplier: PeproTech, Inc.

Description: IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant Human IL-22 is a 33.6 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.

Supplier: PeproTech, Inc.

Description: Recombinant Human CTLA-4 Fc, Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses, Source: CHO cells, superfamily that are expressed, along with the transmembrane glycoproteins B7-1 and B7-2, Synonyms: Cytotoxic T-Lyphocyte-associated antigen 4, Size: 200UG

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Rat RANTES (CCL5). Anti­Rat RANTES (CCL5)­specific antibody was purified by affinity chromatography employing an immobilized Rat RANTES matrix.

Supplier: PeproTech, Inc.

Description: Human IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor, to activate NF-κB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant Human IL-33 is a 17.9 kDa protein containing 159 amino acid residues.

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine GM-CSF. Anti­Murine GM-CSF­specific antibody was purified by affinity chromatography employing an immobilized Murine GM-CSF matrix.

Supplier: PeproTech, Inc.

Description: IL-24 is a secreted glycoprotein belonging to the IL-10 structural family of cytokines. It is produced by a variety of cell types, including B cells, CD4+ cells, NK cells, lymph node DCs, monocytes, and melanoma cells. IL-24 can signal through the IL20R1/IL20R2 and IL22R1/IL20R2 receptors to initiate a signaling cascade, which includes the induction of JAK1/STAT3 phosphorylation. IL-24 is, functionally, a pleiotropic protein, but is generally characterized as an anti-cancer cytokine that can selectively inhibit growth of a wide variety of human cancer cells through activities that include: the induction of differentiation and apoptosis; and the suppression of angiogenesis and cell proliferation. Recombinant Human IL-24 is an 18.9 kDa glycoprotein that contains 161 amino acid residues, including a C-terminal His-tag.

Supplier: PeproTech, Inc.

Description: Sox2 belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and the determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development, including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4 into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in their capacity to form teratomas in immune-deficient mice. Recombinant Human Sox2 is a 34.3 kDa protein containing 317 amino acid residues.

Supplier: PeproTech, Inc.

Description: Prolactin is a neuroendocrine hormone secreted by the pituitary gland. Its primary function is to promote and maintain lactation during pregnancy and suckling. In addition, prolactin plays an immunoegulatory role by stimulating the activities of ornithine decarboxylase and protein kinase C, which are important for the proliferation, differentiation, and function of lymphocytes. Recombinant Rat Prolactin is a 22.6 kDa globular protein containing 198 amino acid residues

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine FGF-9. Anti­Murine FGF-9­specific antibody was purified by affinity chromatography employing an immobilized Murine FGF-9 matrix.

Supplier: PeproTech, Inc.

Description: CD34 is a highly glycosylated type I membrane protein that is selectively expressed on hematopoietic stem cells and vascular endothelium. It has been widely used as a molecular marker for the identification, isolation, and manipulation of hemopoietic stem cells and progenitors. CD34 can function as a regulator of hemopoietic cell adhesion by mediating the attachment of stem cells to bone marrow stromal cells or other bone marrow components. The full length human CD34 is a 385 amino acid protein, consisting of a 31 amino acid signal sequence, a 74 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain and a 259 amino acid extracellular domain. Recombinant Human sCD34 is a 258 amino acid polypeptide containing only the extracellular domain of the full length CD34 protein. The calculated molecular weight of Recombinant Human sCD34 is 27.4 kDa.

Supplier: PeproTech, Inc.

Description: I-309 is a CC chemokine that signals through the CCR8 receptor. It is secreted by T lymphocytes, monocytes and mast cells. I-309 chemoattracts monocytes and Th2 differentiated T-cells, but not neutrophils. Human I-309 is active on murine cells. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric. Recombinant Human I-309 (CCL1) is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines.

Supplier: PeproTech, Inc.

Description: IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and the interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons. Recombinant Human IFN-λ1 is a 19.8 kDa protein containing 178 amino acid residues.

Supplier: PeproTech, Inc.

Description: Produced from sera of goats immunized with highly pure Recombinant Human SCGF-β. Anti­Human SCGF-β­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: PeproTech, Inc.

Description: Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, lymph node, and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute the soluble OPG. Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.

Supplier: PeproTech, Inc.

Description: TGF-beta3, Polyclonal antibody, Host: Rabbit, Species: Human, Immunogen: E.coli derived Recombinant Human TGF-B3, Application: Western Blot, Purity: affinity chromatography, Size: 25UG

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-9. Anti­Murine IL-9­specific antibody was purified by affinity chromatography and then biotinylated.