Human Recombinant OPG (from E. coli)

Supplier: PEPROTECH INC.
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10781-270EA 132.81 USD
10781-270 10781-272 10781-274 10781-276 10781-278 10781-280
Human Recombinant OPG (from E. coli)
Proteins and Peptides

Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, lymph node, and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute the soluble OPG. Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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