Human Recombinant Sox2 (from E. coli)

Supplier: PEPROTECH INC.
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110-03-5UG 110-03-25UG 110-03-100UG 110-03-250UG 110-03-500UG 110-03-1MG
10772-348EA 132.81 USD
10772-348 10772-350 10772-352 10772-354 10772-356 10772-358
Human Recombinant Sox2 (from E. coli)
Proteins and Peptides

Sox2 belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and the determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development, including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4 into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in their capacity to form teratomas in immune-deficient mice. Recombinant Human Sox2 is a 34.3 kDa protein containing 317 amino acid residues.


Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

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