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Supplier: PeproTech, Inc.

Description: TWEAKR belongs to the TNF family of transmembrane proteins, and contains a cytoplasmic "death domain," which can activate a cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAKR can be activated by either membrane-anchored or soluble TWEAK. Recombinant Human TWEAK Receptor is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full-length TWEAKR protein.

Supplier: PeproTech, Inc.

Description: MIA-2 is a secreted cytokine, and a member of the MIA/OTOR family. Members of this family, which also includes MIA, OTOR, and TANGO, share a Src homology-3 (SH3)-like domain. MIA-2 is predominantly expressed in hepatocytes. Elevated levels of MIA-2 may represent a clinically useful marker for diagnosis of hepatic disease activity and severity. Recombinant Human MIA-2 is a 101 amino acid, 11.5 kDa protein comprising the MIA homologous N-terminal region of the full length MIA-2 protein.

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-1β. Anti­Murine IL-1β­specific antibody was purified by affinity chromatography employing an immobilized Murine IL-1β matrix.

Supplier: PeproTech, Inc.

Description: Recombinant Human FGFR3 (IIIc) Fc, Purity: Greater than 95% by SDS-PAGE gel and HPLC analyses, Source: CHO cells, Determined by the dose-dependent stimulation of thymidine uptake, Synonyms: Fibroblast Growth Factor Receptor 3 alpha, ACH, CD333, Size: 50UG

Supplier: PeproTech, Inc.

Description: IL-7 is a hematopoietic growth factor that primarily affects early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors, such as ConA and IL-2. Human and murine IL-7 are cross-species reactive. Recombinant Human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human FGF-acidic. Anti­Human FGF-acidic­specific antibody was purified by affinity chromatography employing an immobilized Human FGF-acidic matrix.

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human TNF-β. Anti­Human TNF-β­specific antibody was purified by affinity chromatography employing an immobilized Human TNF-β matrix.

Supplier: PeproTech, Inc.

Description: Produced from sera of goats immunized with highly pure Recombinant Human Eotaxin (CCL11). Anti­Human Eotaxin (CCL11)­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: PeproTech, Inc.

Description: M-CSF is a potent hematopoietic factor produced by a variety of cells, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their respective progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness and fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant Human M-CSF is a 36.8 kDa homodimeric protein consisting of two 159 amino acid polypeptide subunits.

Supplier: PeproTech, Inc.

Description: Produced from sera of goats immunized with highly pure Recombinant Human FGF-10. Anti­Human FGF-10­specific antibody was purified by affinity chromatography employing an immobilized Human FGF-10 matrix.

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human TNF-α. Anti­Human TNF-α­specific antibody was purified by affinity chromatography employing an immobilized Human TNF-α matrix.

Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-9. Anti­Murine IL-9­specific antibody was purified by affinity chromatography and then biotinylated.

Supplier: PeproTech, Inc.

Description: G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells, including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF is cross-species reactive. Recombinant Murine G-CSF is a 19.0 kDa protein consisting of 179 amino acid residues.Manufactured using all Animal-Free reagents.

Catalog Number: (76303-584)

Supplier: PeproTech, Inc.

Description: PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs, PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types, including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet alpha-granules, and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-alpha and PDGFR-beta. PDGFR-alpha is a high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-beta interacts with only PDGF-BB and PDGF-AB. Recombinant Human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two beta chains (218 total amino acids).

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Catalog Number: (76304-086)

Supplier: PeproTech, Inc.

Description: Irisin is a proteolytic hormone released into circulation by skeletal muscle tissue during acute exercise, and is a derivative of the cleaved plasma membrane protein Fibronectin type III domain-containing protein 5 (FNDC5). Found in muscle tissue, FNDC5 is synthesized at increased levels during exercise as a result of the overexpression of the exercise-responsive transcriptional co-activator PGC-1alpha (peroxisome proliferator-activated receptor-gamma co-activator-1alpha). Like its parent polypeptide, Irisin can induce the browning of subcutaneous adipocytes, or the conversion of white adipose tissue (WAT or white fat) into brown (or beige) adipose tissue (BAT or brown fat). Given that brown fat can undergo thermogenesis, or the physiologic process of heat production, Irisin contributes to the metabolic process by increasing thermogenic function and glucose homeostasis. Irisin, thus, represents a link between exercise and "burning" of fats and/or sugars, and consequently may have relevance in the development of new treatments for diabetes and obesity. CHO cell-derived Recombinant Human/Murine/Rat Irisin is a glycosylated homodimer of 224 amino acid residues, whose monomer consists of 112 amino acid residues corresponding to the active portion of the 121-amino-acid length Irisin extracellular domain. Recombinant Human/Murine/Rat Irisin, appears to form a non-disulfide linked oligomeric structure in solution, has a calculated theoretical molecular weight of 25.2 kDa, but migrates at an apparent molecular weight of 28 kDa by SDS-PAGE analysis under reducing conditions due to glycosylation.

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Supplier: PeproTech, Inc.

Description: Osteoprotegerin (OPG) is a member of the TNFR superfamily that can act as a decoy receptor for RANKL. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. OPG is expressed in a wide variety of tissues, including the adult heart, lung, kidney, liver, spleen, prostate, lymph node, and bone marrow. OPG is secreted both as a monomeric and a dimeric protein. Its primary structure consists of seven distinct domains, four of which correspond to the extracellular cysteine-rich domains of TNFR proteins and constitute the soluble OPG. Recombinant Human OPG is a soluble 20.0 kDa protein containing 174 amino acid residues.