You Searched For: PROSCI INCORPORATED

Catalog Number: (89416-912)

Supplier: Prosci

Description: RCAN2 Antibody: Regulator of calcineurin 2 (RCAN2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin's activity. Unlike isoform 1 of RCAN2, the expression of the second isoform is not induced by the thyroid hormone T3. RCAN2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of RCAN2 are known to exist.

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Catalog Number: (76011-922)

Supplier: Prosci

Description: This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The protein functions in transcription initiation, and is also thought to help stabilize transcribing polyermase molecules during elongation.

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Catalog Number: (10748-736)

Supplier: Prosci

Description: SATB1 Antibody: Human special AT-rich sequence-binding protein-1 (SATB1) is a nuclear matrix/scaffold-associated region DNA-binding protein, predominantly expressed in the thymus and pre-B cells. Like its homolog SATB2, SATB1 selectively binds double-stranded, special AT-rich DNA sequences in which one strand exclusively consists of well-mixed A, T, and C nucleotides. SATB1 contains a dimerization domain that shares similarity with the PDZ motif, identified as an indispensable element for high-affinity binding of SATB1 to DNA. SATB1 constitutes a functional nuclear architecture that has a 'cage-like' protein distribution surrounding heterochromatin and regulates gene expression through chromatin remodeling/HDAC (histone deacetylase complex) and transcription factors recruitment. SATB1 functions as a 'genome organizer' essential for proper T-cell development. Recent studies show that SATB1 is necessary for breast cancer cells to become metastatic, and when ectopically expressed in non-metastatic cells, can induce invasive activity in vivo. At least two isoforms of SATB1 are known to exist.

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Catalog Number: (10749-030)

Supplier: Prosci

Description: The Deltex 4 E3 ubiquitin ligase (DTX4) is a member of a protein family that is involved in Notch signaling and neurogenesis. Recent studies have shown that DTX4 is also associated with the innate immune response. Following the activation of type I interferon signaling, the Nod-like receptor protein 4 (NLRP4) recruits DTX4 for Lys48-linked polyubiquitination and degradation of the kinase TBK1 (NAK), thereby maintaining immune homeostasis during antiviral innate immunity.

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Catalog Number: (89419-996)

Supplier: Prosci

Description: ZBTB2 peptide is used for blocking the activity of ZBTB2 antibody.

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Catalog Number: (10098-398)

Supplier: Prosci

Description: BMPs (bone morphogenetic proteins) belong to the TGF beta superfamily of structurally related signaling proteins. Members of this superfamily are widely represented throughout the animal kingdom and have been implicated in a variety of developmental processes. Proteins of the TGF beta superfamily are disulfide-linked dimers composed of two 12-15 kDa polypeptide chains. As implied by their name, BMPs initiate, promote and regulate bone development, growth, remodeling and repair.

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Catalog Number: (10102-072)

Supplier: Prosci

Description: ZXDA contains 10 C2H2-type zinc fingers. It belongs to the ZXD family. ZXDA cooperates with CIITA to promote transcription of MHC class I and MHC class II genes.

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Catalog Number: (10117-334)

Supplier: Prosci

Description: Polyclonal; Host: Goat; Immunogen: OAZ antibody was raised against a 15 amino acid synthetic peptide near the N-Terminus (near) of OAZ; Application: ELISA

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Catalog Number: (10101-196)

Supplier: Prosci

Description: Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. This gene is part of a tandem repeat on chromosome 15q14; the second copy of this gene is thought to be a pseudogene. Additional splice variants have been described but their full-length nature has not been determined.

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Catalog Number: (10101-822)

Supplier: Prosci

Description: ZNF45 belongs to the krueppel C2H2-type zinc-finger protein family. It contains 18 C2H2-type zinc fingers and 1 KRAB domain. ZNF45 may be involved in transcriptional regulation.

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Catalog Number: (89419-140)

Supplier: Prosci

Description: ATF6 peptide is used for blocking the activity of ATF6 antibody.

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Catalog Number: (10100-098)

Supplier: Prosci

Description: SMYD3 is a member of an RNA polymerase complex. Within the RNA polymerase complex, it acts as a histone methyltransferase that plays a role in transcriptional regulation.SMYD3 is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex.

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Catalog Number: (10075-098)

Supplier: Prosci

Description: Polyclonal, Host: Rabbit; Species Reactivity: Mouse, Rat; Immunogen: Synthetic peptide from human LEG9; Isotype: IgG; Tested Applications: ELISA, IF, IHC, WB

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Catalog Number: (76630-556)

Supplier: Prosci

Description: Anti-VEGFA Recombinant Antibody [Clone: VG76e]

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Catalog Number: (76750-068)

Supplier: Prosci

Description: Anti-CDA Rabbit Polyclonal Antibody

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Catalog Number: (76749-828)

Supplier: Prosci

Description: Anti-CCNE1 Rabbit Polyclonal Antibody

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