You Searched For: PROSCI INCORPORATED

Catalog Number: (10105-024)

Supplier: Prosci

Description: MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. It is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas

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Catalog Number: (10103-152)

Supplier: Prosci

Description: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. VARS belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

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Catalog Number: (10104-346)

Supplier: Prosci

Description: GABARAPL1 increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor.

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Catalog Number: (10115-538)

Supplier: Prosci

Description: Polyclonal antibody Radixin Host: Goat Target Species: Human, Mouse, Rat immunogen: Radixin antibody was raised against a 12 amino acid synthetic peptide near the internal region of Radixin. Application: ELISA, WB

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Catalog Number: (10113-664)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Species Reactivity: Human, Immunogen: PRDM1 antibody was raised against a 12 amino acid synthetic peptide near the C-Terminus of PRDM1, Tested Applications: ELISA, WB

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Catalog Number: (89416-770)

Supplier: Prosci

Description: Stk39 Antibody: The serine/threonine kinase Stk39 belongs to the STE20 family, a group of kinases that are known to interact with inflammation-related kinases (such as p38, JNK, NKCC1, PKC-theta, WNK and MLCK), and with transcription factor AP-1. The STE 20 family is involved in diverse biological phenomena, including cell differentiation, cell transformation/ proliferation, cytoskeleton rearrangement, and the regulation of ion transporters. STK39 contains an N-terminal series of proline and alanine repeats (PAPA box), followed by a serine/threonine kinase catalytic domain and is abundantly expressed in the brain. STK39 is activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled co-transporters. The catalytically active kinase specifically activates the p38 MAP kinase pathway, and its interaction with p38 decreases upon cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Recent studies show that STK39 tend to be a novel candidate gene for autism and hypertension.

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Catalog Number: (89416-962)

Supplier: Prosci

Description: Bora Antibody: Bora (Protein aurora borealis) is a key activator of Aurora Related Protein Kinase A (ARK-1), which is a centrosome-associated serine/threonine kinase that regulates centrosome maturation, bipolar spindle assembly and chromosome segregation during mitosis. Bora is localized to the nucleus until mitosis is initiated, then translocates to the cytoplasm in a Cdc2 dependent manner. Activation of Cdc2 initiates the release of Bora into the cytoplasm where it can bind and activate ARK-1. PLK1 (polo-like kinase-1) interacts with Bora to control the accessibility of its activation loop for phosphorylation and activation by ARK-1. Bora and ARK-1 cooperatively activate PLK1 and control mitotic entry. Bora mutants result in multipolar spindles in mitosis identical to those observed when ARK-1 function is blocked. Thus, the ARK1-Bora-PLK1 regulatory circuit in mammalian cells elucidates a key mechanism in cell cycle regulation. At least three isoforms of Bora are known to exist.

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Catalog Number: (76753-862)

Supplier: Prosci

Description: Anti-PTP4A2 Rabbit Polyclonal Antibody

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Catalog Number: (76763-126)

Supplier: Prosci

Description: Anti-NAT1 Rabbit Polyclonal Antibody

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Catalog Number: (76756-530)

Supplier: Prosci

Description: Anti-FANCD2 Rabbit Polyclonal Antibody

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Catalog Number: (77119-864)

Supplier: Prosci

Description: Influenza A Recombinant Influenza A Strain A/Solomon Islands/03/06 (H1N1) Antigen (from Embryonated chicken eggs)

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Catalog Number: (77132-448)

Supplier: Prosci

Description: CADM4 Peptide

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Catalog Number: (77125-016)

Supplier: Prosci

Description: C20orf75 Peptide

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Catalog Number: (10070-100)

Supplier: Prosci

Description: Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

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Catalog Number: (10113-286)

Supplier: Prosci

Description: Polyclonal, Host: Goat, Immunogen: Fibrillin 2 antibody was raised against a 13 amino acid synthetic peptide near the internal region (near the C-Terminus) of Fibrillin 2 (near the C-Terminus), Tested Applications: ELISA

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Catalog Number: (10097-792)

Supplier: Prosci

Description: Tissue inhibitor of metalloproteinases 1 (TIMP1) and Tissue inhibitor of metalloproteinases 2 (TIMP 2) have similar properties, specifically in inhibiting enzymes of the matrix metalloproteinase family, and are thought to be of great importance in the maintenance of connective tissue integrity. TIMP1 forms a complex of 1:1 stoichiometry with activated interstitial collagenases, activated stromelysin, active form of 72kDa Type IV collagenase (also known as MMP2 or gelatinase A), and latent and active forms of 92kDa Type IV collagenase (also known as MMP0 or gelatinase B). TIMPs inhibit the proteolytic invasiveness of tumour cells and normal placental trophoblast cells. TIMP1 is produced in low (pg/mL) levels by most cell types. Treatment of cells with the phorbol ester TPA stimulates production of TIMP1 in some cell types, but the low protein levels produced often require concentration of cell culture media to visualize the bands by Western Blotting.

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