You Searched For: Van Der Voort Lucht en Milieu Amste

Supplier: Adipogen

Description: Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.

Catalog Number: (102513-502)

Supplier: Adipogen

Description: Bafilomycin C1 is a potential anti-osteoporotic agent in treating bone lytic diseases.

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Supplier: Adipogen

Description: The reagent, a cyanine dye, can be used as a label for the determination of proteins with NIR-fluorescent technology. The absorption-maxima of the reagent lies in a region of low interference by other biomolecules. The isothiocyanate-moiety is used to link the reagent to proteins which can sensitively be detected. Experiments to lower the detection-limits of immunoassays have been done.

Supplier: Adipogen

Description: TG-46 is an inhibitor of JAK2, FLT3, RET, JAK3 with IC(50) values of 6nM, 25nM, 17nM, 169nM respectively.

Supplier: Adipogen

Description: TAE684 is a potent and selective ALK inhibitor with an IC(50) of 3nM. It is 100-fold more sensitive for ALK over InsR.

Supplier: Adipogen

Description: Antibiotic

Catalog Number: (102512-348)

Supplier: Adipogen

Description: Human CD44 molecules appear to serve as lymphocyte adhesion molecules with numerous functions in extracellular matrix binding, cell migration, hemopoisis and lymphocyte homing.

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Catalog Number: (102513-172)

Supplier: Adipogen

Description: Human CD45RA is expressed on all cells of hematopoietic origin, except erythrocytes. CD45RA is a transmembrane tyrosine phosphate which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RA isoform predominates on naive/resting T cells and medullary thymocytes.

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Catalog Number: (102514-494)

Supplier: Adipogen

Description: Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

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Supplier: Adipogen

Description: Fluorescent dye. Fluorophore standard that is widely used in enzyme assay systems. Precursor for a variety of R110-based enzyme substrates for flow cytometric measurements. Used as a calibration standard for R110-based enzyme substrates. Compared to AMC and AFC enzyme substrates, fluorogenic R110 substrates are generally more sensitive, giving longer absorption and fluorescence wavelength than AMC and AFC substrates. Spectral data: lambdaex 498nm| lambdaem 520nm in methanol.

Supplier: Adipogen

Description: Cell permeable resorufin derivative used as a fluorogenic indicator for cell viability. Resorufin was selected as the fluorophore because it fluoresces at a longer wavelength and is amenable to modification at the hydroxyl group which is essential for its fluorescence. Incubation with esterase at pH 8.0 results in a 80-90 nm shift of emission max. (Ex/Em: 500/~593nm in 0.1 M Tris pH 8.0 (after cleavage by esterase)). This cell viability indicator is 2 times more sensitive than calcein-AM.

Supplier: Adipogen

Description: Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.

Supplier: Adipogen

Description: A membrane-impermeable ethylenediaminofluoresceinyl compound that acts as a high-affinity Zn2+-specific fluorescent probe (Kd = 2.7 nM).

Catalog Number: (102988-266)

Supplier: Adipogen

Description: Anticancer compound

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Supplier: Adipogen

Description: Semi-synthetic derivative of artemisinin. Anti-malaria. Anti-schistosomiasis. Inhibitor of human cytomegalovirus (CMV). Apoptosis inducer. Anti-cancer. Immunosuppressant. Inhibits production of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1) and nitric oxide (NO).

Supplier: Adipogen

Description: Fluorescent marker for biochemical applications. Reacts under mild conditions with primary amines. Used in modification of actin at lys-61, labelling of FAB and the modification of thiol groups.