AdipoRon ≥98% (by NMR)

Supplier: Van Der Voort Lucht en Milieu Amste

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AG-CR1-0154-M010 AG-CR1-0154-M050

102988-544EA 76.15 USD

102988-544 102988-546

AdipoRon ≥98% (by NMR)

AdipoRon

Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low µm concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice.

Formula: C₂₇H₂₈N₂O₃
Storage Temperature: Freezer

MDL Number: MFCD08271060
CAS Number: 924416-43-3

Specification Test Results

Purity	>98% (NMR)
Appearance/Color	White solid.
Solubility	Soluble in DMSO, 100% ethanol or methanol. Insoluble in water.

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