You Searched For: Hytest Ltd

Catalog Number: (103007-252)

Supplier: Anaspec Inc

Description: This peptide is a C-terminal surface sorting signal with a conserved LPXTG motif, labeled with the Dabcyl/Edans FRET pair. Sortase cleaves surface proteins at the LPXTG motif and catalyzes the formation of an amide bond between the carboxyl group of threonine and the amino group of cell-wall crossbridges. Sortases are a family of Gram-positive transpeptidases responsible for anchoring surface protein virulence factors to the peptidoglycan cell wall layer. Surface proteins of Staphylococcus aureus are anchored to the bacterial cell wall by a mechanism requiring this C-terminal sorting signal. Cell wall sorting is the covalent attachment of surface proteins to the peptidoglycan via a C-terminal sorting signal that contains a consensus LPXTG sequence. Cleavage of this FRET substrate by sortase reveals the fluorescent signal that may be measured to study sortase activity. Inhibition of the sortase activity is a potential way of treatment of the staphylococcal infection. The LPXTG motif is conserved in more than 100 surface proteins of Gram-positive pathogens.
Sequence:Dabcyl-QALPETGEE-Edans
MW:1472.6 Da
% peak area by HPLC:95
Storage condition:-20° C

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Supplier: Anaspec Inc

Description: 5-TAMRA is the purified single isomer of 5(6)-TAMRA. It is preferred for some complicated biological applications where reproducibility is more critical than material cost since the minor positional difference between 5-TAMRA and 6-TAMRA might affect some biological properties of the underlying conjugates.

Supplier: Anaspec Inc

Description: Beta-Amyloid (1-42) peptide, a major component of amyloid plaques, accumulates in neurons of Alzheimer’s disease brains. Biochemical analysis of the amyloid peptides isolated from Alzheimer’s disease brain indicates that Beta-Amyloid (1-42) is the principal species associated with senile plaque amyloids, while Beta-Amyloid (1-40) is more abundant in cerebrovascular amyloid deposit.
Sequence: DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Molecular Weight: 4514.1 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

Catalog Number: (103010-238)

Supplier: Anaspec Inc

Description: Matrix metalloproteinases (MMPs) belong to a family of secreted or membrane-associated zinc endopeptidases capable of digesting extracellular matrix components

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Catalog Number: (103010-484)

Supplier: Anaspec Inc

Description: Renin, a highly specific aspartyl protease, cleaves angiotensinogen, produced in the liver, to yield angiotensin I, which is further converted into angiotensin II by ACE (Angiotensin Converting Enzyme). Angiotensin II constricts blood vessels, leading to increased blood pressure. It also increases the secretion of ADH and aldosterone, and stimulates the hypothalamus to activate the thirst reflex. Since an overactive renin-angiotensin system leads to hypertension, renin is proposed as a therapeutic target for this disease.

Recombinant rat pro-renin was expressed in HEK cells. Purified enzyme was converted to the active renin by tryptic activation followed by removal of trypsin. The molecular mass of active rat renin is approximately 40 kDa. The activity of enzyme can be measured in FRET-based assays

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Catalog Number: (103007-556)

Supplier: Anaspec Inc

Description: This peptide is a thrombin receptor activating peptide. This PAR-1 agonist peptide reversibly binds to PAR-1 mimicking the 'tethered ligand' that thrombin makes available through proteolytic cleavage of substrate. It is also known to cause increase in liquid and protein permeability much like thrombin.
Sequence: TFLLRNPNDK - NH2
MW: 1216.4 Da
% Peak Area by HPLC: ≥ 95%
Storage condition: -20°C

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Catalog Number: (103011-366)

Supplier: Anaspec Inc

Description: Widely used for measuring membrane potential of mitochondria; 585/520 Fluorescence ratio increases upon cell hyper-polarization.

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Catalog Number: (103007-390)

Supplier: Anaspec Inc

Description: This peptide is amino acids 276 to 286 fragment of the lymphocytic choriomeningitis virus (LCMV) glycoprotein (GP), also known as GP276. It is the H-2Db restricted epitope. LCMV has been routinely exploited for the study of adaptive immune responses to viral infection. Fifty to seventy percent of CD8 T cells at the peak of LCMV infection appear to be specific for five LCMV-derived epitopes including GP276.
Sequence:SGVENPGGYCL
MW:1095.2 Da
% peak area by HPLC:95
Storage condition:-20° C

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Catalog Number: (103007-788)

Supplier: Anaspec Inc

Description: This peptide is derived from rat angiotensinogen amino acid residues 1-14. It is a synthetic renin substrate.
Sequence: DRVYIHPFHLLYYS
MW: 1823.1 Da
% Peak area by HPLC: 95
Storage condition: -20°C

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Catalog Number: (103005-938)

Supplier: Anaspec Inc

Description: Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.
This peptide is a sensitive substrate for assaying MMP-1, 2, 7, 8, 12 and 13 activities, Abs/Em = 494/521nm.
Sequence:5-FAM-RPKPYA-Nva-WM-K(QXL™ 520)-NH2
MW:2125.4 Da
% peak area by HPLC:95
Storage condition:-20° C

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Catalog Number: (103007-748)

Supplier: Anaspec Inc

Description: This is a short fragment of the b-Amyloid peptide containing Histidine 13 and 14. Alzheimer’s beta amyloid peptides form A? ion channels in lipid bilayers. It is postulated that ion channel activity of A? is related to cytotoxic activity of A?. Small peptides that contain the amino acid sequence of the predicted mouth region of the A? channel pore can inhibit A? ion channel activity. And, Histidines 13 and 14 have been shown to be essential for the peptide to inhibit Alzheimer’s disease A? ion channel and cytotoxicity.
Sequence: EVHHQKL
Molecular Weight: 890 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

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Catalog Number: (103009-986)

Supplier: Anaspec Inc

Description: This peptide is derived from bovine peripheral myelin P2 protein amino acid residues 53-78. It is neuritogenic, inducing experimental autoimmune neuritis (EAN) in Lewis rats.
Sequence:TESPFKNTEISFKLGQEFEETTADNR
MW:3019.9 Da
% peak area by HPLC:95
Storage condition:-20° C

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Supplier: Anaspec Inc

Description: Streptavidin, nonglycosylated, tetrameric protein, 55,000-dalton, with each subunit able to bind a single molecule of the vitamin biotin, purified from Streptomyces avidinii, Physical State: Lyophilized powder, Solvent System: water, Storage -20 deg C desiccated, Size: 100mg

Catalog Number: (103008-960)

Supplier: Anaspec Inc

Description: Histone deacetylase (HDAC) enzymes modulate gene expression through the deacetylation of lysine residues on histone proteins and act as transcriptional repressors of genes

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Catalog Number: (103007-100)

Supplier: Anaspec Inc

Description: This amino acids 22 to 27 fragment is a modification of the human islet amyloid polypeptide hIAPP (NFGAIL) with N-methylation of the amide bonds at G24 and I26. The introduction of two N-methyl rests in the amyloid-core-containing sequence NFGAIL converts this amyloidogenic and cytotoxic sequence into non-amyloidogenic and non-cytotoxic peptide. The peptide is able to bind with high-affinity full-length hIAPP and to inhibit its fibrillogenesis.
Sequence: NF-(NMe-G)-A-(NMe-I)-L
Molecular Weight: 661.8 Da
% Peak Area by HPLC: ≥95
Peptide Content: ≥ 60%
Storage condition: -20°C

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Supplier: Anaspec Inc

Description: One of the three mammalian Natriuretic peptides, A-type is the Atrial natriuretic peptide (ANP) also called Cardiodilatin (CDD). ANP (1-28) peptide hormone constitutes the first 28 amino acids of the ANP synthesized in the heart of different vertebrates. It plays an important role in the regulation of blood pressure and natriuresis/diuresis. Residues Phe8, Arg14 and the C-terminal sequence of ANP are known to bind to human NPR-A (Natriuretic peptide receptor type A).
Sequence:SLRRSSCFGGRMDRIGAQSGLGCNSFRY (Disulfide bridge: 7-23)
MW:3080.5 Da
%Peak area by HPLC:≥95%
Storage condition: -20°C