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Catalog Number: (76634-424)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with mast cells distributed in skin, synovium, lung, and heart. This antibody does not bind with any other cell type. Mast cells contain a number of preformed chemicals mediators such as histamine, chymase, carboxypeptidase, and proteolytic tryptase. Human mast cell tryptase is considered to be an important marker of mast cell activation and is an important mediator of inflammation.

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Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 70 kDa protein. COX-2 (Cyclooxygenase-2) is an inducible enzyme. It is involved in the response of cells to growth factors, tumor promoters and cytokines that induce its expression. COX-2 expression markedly increased in 85 to 90% of human colorectal adenocarcinoma whereas COX-1 levels remained unchanged.

Catalog Number: (76634-536)

Supplier: Diagnostic Biosystems

Description: Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms' tumor. In patients with HCC, GPC3 is overexpressed in neoplastic liver tissue and elevated in serum, but is undetectable in normal liver, benign liver, and the serum of healthy donors. GPC3 expression is also found to be higher in HCC liver tissue than in cirrhotic liver or liver with focal lesions such as dysplastic nodules and areas of hepatic adenoma (HA) with malignant transformation. In the context of testicular germ cell tumors, GPC3 expression is up regulated in certain histologic subtypes, specifically yolk sac tumors and choriocarcinoma. A high level of GPC3 expression is also found in some types of embryonal tumors, such as Wilms' tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100% in follicular carcinoma and 70% in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that offollicular adenoma.

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Supplier: Diagnostic Biosystems

Description: This antibody is specific to macrophages in a wide variety of human tissues. It reacts with myeloid precursors and peripheral blood granulocytes. It also stains a cell population known as plasmacytoid T cells.

Supplier: Diagnostic Biosystems

Description: PermaBlack/HRP is a substrate-chromogen system designed to be used for either IHC or ISH when utilizing horseradish peroxidase

Supplier: Diagnostic Biosystems

Description: This antibody is specific to 54 kDa protein. Cytokeratin 13 belongs to the type A (acidic) subfamily of low molecular weight cytokeratins and exists in combination with cytokeratin 4. Cytokeratin 13 is expressed in squamous, non-keratinized epithelium, transitional epithelium and myoepithelium. This antibody is useful for the identification of carcinomas of trachea, sweat glands, bladder, ectocervix, tongue, esophagus, anal canal and the basal layer of keratinized epidermis.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 32 kDa protein, which is identified as Caspase 3. Caspase 3 is associated with induction of apoptosis. Caspase 3 is ubiquitously expressed and is synthesized as an inactive proenzyme.

Supplier: Diagnostic Biosystems

Description: Complement 4d (C4D) is the most clinically used marker for humoral rejection. It is a degradation product of the activated complement factor C4B. Complement 4D is typically initiated by binding of antibodies to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. Complement 4D is also found in intracytoplasmic vacuoles of endothelial cells. Covalent binding renders C4D a stable molecule that can easily be detected by immunohistochemistry.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes CD5, which is a transmembrane protein, is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Occasionally, CD5 antigen is also expressed on a subset of B cells. Mantle cell lymphomas (same as diffuse centrocytic lymphomas) are CD5(+) while the follicle center cell lymphoma are CD5(-).

Catalog Number: (76634-262)

Supplier: Diagnostic Biosystems

Description: This antibody is a member of a family of complex antigens, which also includes non-specific cross-reacting antigens (NCA). This antibody stains specific regions of CEA. It reacts with colorectal adenocarcinomas but does not show any staining with polymorphonuclear neutrophils and erythrocytes.

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Catalog Number: (76634-904)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes a c-erbB-2 protein, which is a receptor tyrosine kinase of the c-erbB family. It is closely related in structure to the epidermal growth factor receptor. c-erbB-2 oncoprotein is detectable in a subset of breast and other adenocarcinomas, as well as transitional cell carcinomas. In the case of breast cancer, expression determined by immunohistochemistry has been shown to be associated with poor prognosis.

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Supplier: Diagnostic Biosystems

Description: This antibody recognizes a protein of 38kDa, identified as synaptophysin. It labels normal neuroendocrine cells of human adrenal medulla, carotid body, skin, pituitary gland, thyroid, lung, pancreas, gastrointestinal mucosa, Paneth’s cells in the gastrointestinal tract and gastric parietal cells. Neurons in the brain, spinal cord, and retina are also labeled. In combination with anti-chromogranin A and anti-NSE, anti-synaptophysin is very useful in the identification of normal neuroendocrine cells and neuroendocrine neoplasms.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 180 kDa protein, known as Flt-1 or vascular endothelial growth factor receptor 1 (VEGFR1). Flt-1 is a cell membrane receptor kinase. Flk-1 has a high affinity receptor for vascular endothelial growth factor and is putatively involved in the growth of endothelial cells and angiogenesis.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 145 kDa protein. CD117/c-kit is a transmembrane receptor tyrosine kinase and is expressed in many tissues and cells. CD117/c-kit is involved in the development of several lineages of stem cells, such as germ cells, neural crest derived melanocytes and hematopoietic precursor cells. This antibody can be used in the identification of gastrointestinal stromal tumors.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with γ-chains of human IgG. Nonspecific antibodies have been removed by solid-phase adsorption.

Supplier: Diagnostic Biosystems

Description: This antibody is specific to β sialoglycophorin also known as glycophorin C. Glycophorin C is found on the human erythrocyte membrane and is one of four sialic acid-rich polypeptides.