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Catalog Number: (76634-358)
Supplier: Diagnostic Biosystems
Description: This antibody is specific to two proteins of 185 kDa and 145 kDa, identified as two isoforms of neural cell adhesion molecules (NCAM/CD56). NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasms such as retinoblastoma, medulloblastoma, astrocytoma and neuroblastoma.


Catalog Number: (10065-176)
Supplier: Diagnostic Biosystems
Description: The Picro-Sirius Red Stain Kit (For Collagen) is intended for use in the histological visualization of collagen I and III fibers in addition to muscle in tissue sections.


Catalog Number: (76634-460)
Supplier: Diagnostic Biosystems
Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.


Catalog Number: (76634-456)
Supplier: Diagnostic Biosystems
Description: PAX 8 is expressed in a high percentage of renal cell carcinomas and ovarian cancers. This mouse monoclonal PAX 8 antibody [4H7B3] has been designed to target restricted epitopes, and exhibits higher specificity and provides sharper staining than the PAX 8 rabbit polyclonal antibody. Unlike the polyclonal PAX 8, this mouse monoclonal antibody does not stain B-cells, and does not recognize epitopes of pancreatic origin and neuroendocrine cells in stomach and colon; thus providing superior specificity. The expression of the mouse monoclonal PAX 8 targets antigens found in normal kidney, thyroid and cervix, but not normal ovary. PAX 8 stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded tissues.


Supplier: Diagnostic Biosystems
Description: Wilms tumor-1 (WT-1) is a gene involved in the induction of Wilms tumor, a pediatric renal malignancy. Wilms tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilms tumor and mesothelioma.

Catalog Number: (95041-478)
Supplier: Diagnostic Biosystems
Description: DAB is widely used chromogen for immunoperoxidase staining, is well accepted among pathologists because of its high sensitivity and cleaner background than aminoethylcarbazole (AEC).


Catalog Number: (76634-838)
Supplier: Diagnostic Biosystems
Description: This antibody recognizes a protein of 67kDa, which is identified as estrogen receptor (ER). ER content of breast cancer tissue is an important parameter in the prediction of prognosis and response to endocrine therapy. This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland. Presence of ER in breast tumors indicates an increased likelihood of response to anti-estrogen (e.g. tamoxifen) therapy.


Catalog Number: (10065-078)
Supplier: Diagnostic Biosystems
Description: This antibody is specific to 34 kDa protein known as myogenin. Myogenin is a member of family of myogenic regulatory genes which includes MyoD, myf5 and MRF4. These genes encode a set of transcription factors which are essential for muscle development. Expression of myogenin is restricted to cells of skeletal muscle origin.


Catalog Number: (76634-288)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with a subset of B-lymphocytes localized in the follicular mantle zone. It reacts with 97% of hairy cell leukemia cases. This antibody shows strong positive staining of about 35% of cases of high grade B cell lymphomas.


Catalog Number: (76634-854)
Supplier: Diagnostic Biosystems
Description: This antibody reacts specifically with a 32 kDa protein similar to the CD8 molecule. This antibody stains cytotoxic/suppressor T cells and shows staining patterns similar to clustered CD8 monoclonal antibodies.


Catalog Number: (10064-764)
Supplier: Diagnostic Biosystems
Description: DAB, is a widely used chromogen for immunoperoxidase staining, and is well accepted among pathologists because of its increased sensitivity and decreased background when compared to amino ethylcarbazole (AEC)


Catalog Number: (99990-034)
Supplier: Diagnostic Biosystems
Description: This antibody reacts with the human C3c complement and the C3c part of C3 and C3b. It may cross react with the C3c complement from cat, cow, dog, goat, guinea pig, kangaroo, mink, mouse, rat, sheep, and swine. Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. This antibody is well suited for tissue section staining but may be also used for other applications.


Catalog Number: (76634-884)
Supplier: Diagnostic Biosystems
Description: Mesothelin is a glycocylphosphotidylianositol-linked cell-surface glycoprotein, which is present on the surface of normal mesothelium and is overexpressed in many patients with epithelial ovarian cancer and malignant mesotheliomas.


Supplier: Diagnostic Biosystems
Description: This antibody reacts with a protein of 81 kDa. Ezrin serves as a tyrosine kinase substrate and is phosphorylated in EGF-stimulated cells. Ezrin is a cytoplasmic protein, enriched in microvilli and other cell surfaces. Ezrin has an actin-binding capacity. Ezrin is expressed in epithelial cells but not in mesenchymal cells. Ezrin is also expressed by certain epithelial tumors, such as renal cell adenocarcinomas.

Catalog Number: (99990-062)
Supplier: Diagnostic Biosystems
Description: Buffer for washing tissue during IHC.


Catalog Number: (99990-084)
Supplier: Diagnostic Biosystems
Description: To reduce nonspecific staining during IHC.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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