You Searched For: N-Palmitoyl ceramide

Supplier: Diagnostic Biosystems

Description: This antibody reacts with human isoenzymes of neuron specific enolase containing γ subunits. This antibody gives a specific staining in neurons of the brain, in islets of Langerhans in pancreas and in peripheral nerves of the skin. No staining with other tissue types has been seen.

Supplier: Diagnostic Biosystems

Description: This antibody reacts specifically with CA 125 ovarian cancer antigen. Several studies have shown that CA 125 is a useful tumor marker for ovarian epithelial malignancies. However, CA 125 has been described in other neoplasms such as seminal vesicle and anaplastic lymphomas.

Supplier: Diagnostic Biosystems

Description: Anti-Cytokeratin (CAM 5.2) reagent has a primary reactivity with human keratin proteins that correspond to Moll’s peptides #7 and #8, Mr 48 and 52 kilodaltons (kd), respectively. Cytokeratin 7 and 8 are present on secretory epithelia of normal human tissue but not onstratified squamous epithelium. Anti-Cytokeratin (CAM 5.2) stains most epithelial-derived tissue, including liver, renal tubular epithelium, and hepatocellular and renal cell carcinomas. Anti-Cytokeratin (CAM 5.2) might not react with some squamous cell carcinomas.

Catalog Number: (99990-048)

Supplier: Diagnostic Biosystems

Description: This antibody reacts with the human C1q complement. Traces of contaminating antibodies have been removed by solid phase absorption with human plasma proteins. This antibody is well suited for tissue section staining but may also be used for other applications.

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Supplier: Diagnostic Biosystems

Description: This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.

Catalog Number: (76634-402)

Supplier: Diagnostic Biosystems

Description: The HMB45 clone reacts with a neuraminidase-sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. The HMB45-reactive antigen is present in cutaneous melanocytes, prenatal and infantile retinal pigment epithelium and melanoma cells and is thought to be oncofetal in nature. This antibody has been shown to label the majority of melanomas. Clone A103 recognizes a protein of 20 kDa, identified as MART-1 (melanoma antigen recognized by T cells-1) or Melan-A. Melan-A is a useful addition to melanoma panels as it is apparently specific for melanocytic lesions. Studies have also shown that MART-1 is more sensitive than HMB45 when labeling metastatic melanomas. Tyrosinase is a key enzyme involved in the initial stages of melanin biosynthesis. Studies have shown tyrosinase to be a more sensitive marker when compared to HMB45 and MART-1. It has been shown to label a higher percentage of desmoplastic melanomas than HMB45. The combination of HMB45, MART-1 and tyrosinase make this triple antibody cocktail a first-order pan melanoma screener.

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Catalog Number: (10065-004)

Supplier: Diagnostic Biosystems

Description: PAX 8 is expressed in a high percentage of renal cell carcinomas and ovarian cancers. This mouse monoclonal PAX 8 antibody [BC12] has been designed to target restricted epitopes, and exhibits higher specificity and provides sharper staining than the PAX 8 rabbit polyclonal antibody. Unlike the polyclonal PAX 8, this mouse monoclonal antibody does not stain B-cells, and does not recognize epitopes of pancreatic origin and neuroendocrine cells in stomach and colon; thus providing superior specificity. The expression of the mouse monoclonal PAX 8 targets antigens found in normal kidney, thyroid and cervix, but not normal ovary. PAX 8 stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded tissues.

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Catalog Number: (76633-186)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes keratin polypeptides of 68, 58, 56.5 and 50 kDa in the stratum corneum. The antibody reacts with squamous, ductal and other complex epithelia. It stains adenocarcinomas, breast, pancreas, bile duct, salivary gland and transitional cell carcinomas.

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Supplier: Diagnostic Biosystems

Description: Monoclonal anti-smooth muscle myosin reacts with myosin heavy chain polypeptides of 200 and 204 kDa. It does not react with skeletal, cardiac, or non-muscle myosin. In immunohistochemistry it stains vascular and visceral smooth muscle cells and cells that have smooth muscle-like characteristics.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with the zymogen as well as the activated form of cathepsin D. It stains fibroblasts and macrophages strongly but stains weakly with the myoepithelial cells of breast. It stains the sweat ducts and glands in the skin, islets cells and granules of pancreatic acini.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with the c-erbB-2 oncoprotein, a 190 kDa protein. The proto-oncogene for c-erbB-2 is located on the human chromosome 17, band 21. It has structural similarities to EGFR. Several studies have indicated that c-erbB-2 may be a good indicator of the prognosis of human carcinomas in the breast, ovary, uterus and gastrointestinal tract.

Catalog Number: (10065-156)

Supplier: Diagnostic Biosystems

Description: The Mouse UnoVue HRP/DAB Detection System is a polymer-based 1-step horseradish peroxidase-labeled detection system for immunohistochemistry. This kit can detect mouse IgG and IgM antibodies, with significantly lower background than biotin/avidin detection systems.

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Supplier: Diagnostic Biosystems

Description: This antibody reacts with a 32-34 kDa protein known as replication protein A (RPA). RPA is involved in DNA replication, repair and recombination. Human RPA is a stable heterotrimer of 70 kDa, 32-34 kDa and 11-14 kDa subunits (RPA70, RPA32 and RPA14 respectively). RPA is required for the SV40 large tumor antigen-catalyzed unwinding for SV40 DNA and stimulates DNA polymerase α and δ.

Supplier: Diagnostic Biosystems

Description: Anti-Cytokeratin (CAM 5.2) reagent has a primary reactivity with human keratin proteins that correspond to Moll’s peptides #7 and #8, Mr 48 and 52 kilodaltons (kd), respectively. Cytokeratin 7 and 8 are present on secretory epithelia of normal human tissue but not onstratified squamous epithelium. Anti-Cytokeratin (CAM 5.2) stains most epithelial-derived tissue, including liver, renal tubular epithelium, and hepatocellular and renal cell carcinomas. Anti-Cytokeratin (CAM 5.2) might not react with some squamous cell carcinomas.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with a neuraminidase sensitive oligosaccharide side chain of a glycoconjugate present in immature melanosomes. It reacts with junctional and blue nevus cells. Non-melanocytic cells are negative.

Catalog Number: (76634-346)

Supplier: Diagnostic Biosystems

Description: This antibody recognizes keratin polypeptide of 54 kDa. It stains a number of epithelial cells including ductal and glandular epithelia. Stratified squamous epithelia are positive but transitional epithelium of the urinary tract does not show any staining. This antibody labels adenocarcinomas and transitional carcinomas but does not react with squamous cell carcinomas.

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