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Supplier: Diagnostic Biosystems

Description: p63 is a homolog of the tumor suppressor p53, it is identified in basal cells in the epithelial layers of a variety of tissues, including epidermis, cervix, urothelium, breast and prostate. p63, vital for the development of the prostate and selectively expressed by normal prostate basal cells, has been shown to be a promising complementary basal cell specific marker to High Molecular Weight-Cytokeratin (HMW-CK), for the differential diagnosis of benign prostatic lesions and prostatic carcinoma. p63 has also been shown to be a sensitive marker for lung squamous cell carcinomas (SqCC), with a sensitivity of ~90% . Specificity for lung SqCC, vs. lung adenocarcinoma (LADC), is approximately 80. In breast tissue, p63 has been identified in myoepithelial cells of normal ducts.

Catalog Number: (99990-370)

Supplier: Diagnostic Biosystems

Description: Clone number KP1, This antibody is specific to macrophages in a wide variety of human tissues. It reacts with myeloid precursors and peripheral blood granulocytes. It also stains a cell population known as Plasmacytoid T cells.

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Supplier: Diagnostic Biosystems

Description: SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. Alterations in the SMAD4 gene was primarily discovered in pancreatic cancer (duct adenocarcinoma) but occur in a variety of cancers such as colorectal cancer, gastric cancer, prostate cancer, melanomas, head and neck cancers and many others, though with higher frequencies in gastrointestinal tract cancers. Loss of SMAD4 expression in tumors has also been shown to affect cancer progression and therapy, such as reduced response to adjuvant chemotherapy.

Catalog Number: (10065-008)

Supplier: Diagnostic Biosystems

Description: E-cadherin (uvomorulin, cell-CAM120/80) is a calcium dependent cell adhesion molecule expressed predominately in epithelial tissues. It plays an important role in the growth and development of cells via the mechanisms of control of tissue architecture and the maintenance of tissue integrity. Numerous studies have demonstrated that reduction and/or loss of E-cadherin expression in carcinomas correlates positively with the potential of these tumors for invasion and metastasis.

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Supplier: Diagnostic Biosystems

Description: This antibody reacts with 70 and 200 kDa component of the neurofilament polypeptide subunit. It stains neurons, neuronal processes and peripheral nerves. This antibody reacts with some neuroblastomas and gangliomas but not with other non-neuronal tumors.

Supplier: Diagnostic Biosystems

Description: CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.

Supplier: Diagnostic Biosystems

Description: This antibody reacts with an antigen expressed by normal and neoplastic T cells and myeloid lineage cells. It strongly stains T cells in the interfollicular areas of normal lymphoid tissues.

Supplier: Diagnostic Biosystems

Description: Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells, which express CD30 antigen and the epithelial membrane antigen (EMA). These tumor cells tend to occur in younger patients and may be associated with cutaneous and extranodal involvement. Large cell lymphoma account for approximately 25% of all non-Hodgkin lymphomas in children and young adults.

Catalog Number: (76634-392)

Supplier: Diagnostic Biosystems

Description: This antibody cocktail reacts with cytokeratin 5 intermediate filament protein as well as the 50 kDa cytokeratin protein designated cytokeratin 14. Basal cells of human epidermis express acidic cytokeratin 14 and basic cytokeratin 5. Cytokeratin 5 is a 58 kDa protein, which is closely related to cytokeratin 6. Cytokeratin 5 and 6 are expressed in basal cell epithelioma, basal cells of prostate, urothelium, vagina, squamous cell carcinomas of skin, tongue, epiglottis and rectal-anal region. Cytokeratin 5 can be useful in the distinction of mesotheliomas from most adenocarcinomas.Cytokeratin 14 belongs to the type A (acidic) subfamily of low MW cytokeratins and exists in combination with cytokeratin 15. This antibody can be useful to distinguish stratified epithelial cells from simple epithelial cells.

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Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 110 kDa human CD57 myeloid associated glycoprotein. It stains mononuclear cells with natural killer activity, neuroendocrine cells and their tumors.

Catalog Number: (76634-352)

Supplier: Diagnostic Biosystems

Description: This antibody is specific to a 40 kDa protein, which is identified as thyroid transcription factor (TTF-1). TTF-1 is expressed in epithelial cells of the thyroid gland and lung. TTF-1 stains primary lung adenocarcinoma and small cell carcinoma but does not stain colon and breast carcinoma.

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Supplier: Diagnostic Biosystems

Description: This antibody is specific to an oncofetal antigen of >1,000 kDa known as tumor associated glycoprotein (TAG-72) or CA 72-4. This antibody defines the mucin carried sialylated-Tn antigen. This antibody stains the majority of human adenocarcinomas including colorectal, pancreatic, gastric, ovarian, endometrial, mammary and non-small cell lung cancer.

Supplier: Diagnostic Biosystems

Description: Uroplakins (UPs) are a family of transmembrane proteins (UPs Ia, Ib, II and III) that are specific differentiation products of urothelial cells. Uroplakins are markers of terminally differentiated urothelium. Uroplakin II (UPII) is a newly described sensitive marker for urothelial carcinoma (UC). The expression profile of UPII in different types of UC and its utility in the diagnostic setting are needed.

Supplier: Diagnostic Biosystems

Description: Cytokeratin 15 is a type I cytokeratin without a defined type II partner. Cytokeratin 15 is expressed primarily in the basal keratinocytes of stratified tissues, including the fetal epidermis and fetal nail.

Supplier: Diagnostic Biosystems

Description: This antibody recognizes heavy chain of human skeletal myosin. It does not stain cardiac or smooth muscle myosin. This antibody stains the fast twitch (type II) isomyosin molecule.

Catalog Number: (95029-774)

Supplier: Diagnostic Biosystems

Description: Prediluted mouse monoclonal antibody, clone T311. 6ml.

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