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Catalog Number: (103264-612)

Supplier: Southern Biotechnology

Description: Ly-6C is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on bone marrow cells, monocytes/macrophages, neutrophils, endothelial cells, and T-cell subsets. Mice with the Ly-6.2 allotype (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have subsets of CD4+Ly-6C+ and CD8+Ly-6C+ cells while Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have only CD8+Ly-6C+ lymphocytes. Ly-6C may play a role in the development and maturation of lymphocytes.

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Catalog Number: (103264-502)

Supplier: Southern Biotechnology

Description: Alexa Fluor 647 Anti-Mouse IgG1 antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (100243-890)

Supplier: Southern Biotechnology

Description: The monoclonal antibody 2F1 reacts with mouse killer cell lectin-like receptor G1 (KLRG1; formerly known as mouse MAFA), a homodimeric member of the lectin-like type 2 transmembrane receptor family that contain characteristic immunoreceptor tyrosine-based inhibitory motifs (ITIMs) in their cytoplasmic domains. These ITIMs interact with the SH2 domains of protein phosphatases such as SHP-1. The 2F1 antibody stains 30-60% of NK1.1+CD3- splenocytes, and a small fraction of T cells in all mouse strains tested (C57BL/6, BALB/c, 129/J, C3H.SW, AKR/J, SJL). Cell surface expression of KLRG1 is up-regulated by expression of MHC class I molecules. The effect of MHC class I expression is indirect, and can be mediated by interactions with class I-specific Ly49 inhibitory receptors.

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Catalog Number: (103265-398)

Supplier: Southern Biotechnology

Description: CD45, also known as the leukocyte common antigen (LCA), exists as four different isoforms (180, 190, 205, 220 kDa) that are generated by alternative splicing of three exons. LCA is found on all cells of hematopoietic origin, except erythrocytes and platelets. CD45 expression is required for T cell and B cell antigen receptor-mediated activation.

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Catalog Number: (100244-616)

Supplier: Southern Biotechnology

Description: FITC Anti-Rat IgG2c antibody for use in flow cytometry and immunohistochemistry assays.

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Catalog Number: (100243-332)

Supplier: Southern Biotechnology

Description: CD24, also known as heat stable antigen, is a phosphatidylinositol-linked cell surface glycoprotein that is expressed at all stages of B cell development and on most thymocytes. The absence of expression from mature T cells is closely associated with their maturation from CD4+CD8+CD24+ thymocytes to either CD4+CD8-CD24- or CD4-CD8+CD24- T cells. CD24 is also present on mouse granulocytes, monocytes, Langerhans cells and erythrocytes. Its ligand is P-selectin (CD62P). CD24 may play a role in regulation of B cell proliferation and differentiation, and it has been proposed that heat stable antigen promotes homotypic adhesion between B lymphocytes.

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Catalog Number: (103265-066)

Supplier: Southern Biotechnology

Description: Donkey Anti-Mouse IgG(H+L)-Alexa Fluor 647 antibody with minimal reactivity to human, goat, sheep, bovine, rabbit, chicken, horse, and guinea pig serum proteins for use in immunocytochemistry assays.

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Catalog Number: (100244-182)

Supplier: Southern Biotechnology

Description: The 3C4 monoclonal antibody reacts with the cell surface glycoprotein mouse CD102 (ICAM-2), a ligand for the leucocyte integrin CD11a/CD18 (LFA-1). CD102 is constitutively expressed on T cells, B cells, and at high levels on vascular endothelial cells. It is also expressed on a variety of leukocyte cell lines. The 3C4 antibody blocks the interaction between ICAM-2 and LFA-1.

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Catalog Number: (100242-082)

Supplier: Southern Biotechnology

Description: Purified Rat IgG2a for use as a control in flow cytometry, immunohistochemistry, immunoprecipitation, and in vitro assays and as a standard in ELISA.

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Catalog Number: (100242-534)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Mouse IgG(H+L)-PE/CY5 (SPRD) antibody with minimal reactivity to human proteins for use in flow cytometry assays.

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Catalog Number: (100243-002)

Supplier: Southern Biotechnology

Description: Laminins, a family of extracellular matrix glycoproteins, are a major component of basement membranes consisting of an α-chain, a β-chain, and a γ-chain. Laminins have been implicated in a numerous biological activities including cell migration, adhesion, and differentiation.

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Catalog Number: (100243-288)

Supplier: Southern Biotechnology

Description: CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. Studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow.

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Catalog Number: (103264-702)

Supplier: Southern Biotechnology

Description: Goat Anti-Human Ig-Alexa Fluor 647 antibody for use in flow cytometry, immunocytochemistry, and western blotting assays.

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Catalog Number: (100243-700)

Supplier: Southern Biotechnology

Description: CD90 (Thy-1) is a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily consisting of a single V-set domain. The Thy-1.2 alloantigen is expressed on all thymocytes, peripheral T lymphocytes, and some intraepithelial T cells of most mouse strains. It is also expressed in the brain and at varying levels on other non-lymphoid tissues. The 30-H12 monoclonal antibody does not cross react with mouse and rat strains bearing the Thy-1.1 alloantigen (e.g., AKR/J, PL).

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Catalog Number: (100241-940)

Supplier: Southern Biotechnology

Description: Mouse IgG2b-APC for use as a control in flow cytometry assays.

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Catalog Number: (100243-278)

Supplier: Southern Biotechnology

Description: CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. Studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. The monoclonal antibody 6D5 recognizes the same epitope as the published clone, 1D3.

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