VWR International - Chemicals and Laboratory Scientific Supplies

Cyclic AMP ELISA Kit, Cayman Chemical Company

Description: For direct quantification of cAMP from a variety of biological samples

Catalog Number: 75817-364

Supplier: Cayman Chemical Company

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4,4′-Dianilino-1,1′-binaphthyl-5,5′-disulfonic acid dipotassium salt ≥98%, crystalline solid fluorescent dye

Description: bis-ANS is a high-affinity non-covalent extrinsic fluorescent dye used to analyze protein conformation. Its predominant interaction with proteins is through its hydrophobic phenyl and naphthyl rings.

Catalog Number: 76305-450

Supplier: Cayman Chemical Company

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6-keto Prostaglandin F_1α ELISA Kit, Cayman Chemical Company

Description: For the quantification of 6-keto PGF1α in various samples.

Catalog Number: 75816-882

Supplier: Cayman Chemical Company

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JWH 018 (CRM), Cayman Chemical

Description: A Certified Reference Material

Catalog Number: 76544-492

Supplier: Cayman Chemical Company

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Human Recombinant STING R224 variant (from E. coli)

Description: STING R224 variant (human recombinant) contains amino acids 138-379 of the wild-type variant (R232) with lysine 224 substituted with arginine. Stimulator of interferon genes (STING) is a component of the innate immune response that binds to cyclic dinucleotides, which are bacterial second messengers, leading to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN). The R232 variant of STING is the most common variant in the human population, found at a frequency of 57.9% in the 1000 Genome Project. The SNP variant H232 is found at a 13.7% frequency. The K224R mutation prevents ubiquitination of STING at position K224, a process which is essential for efficient cytosolic DNA-mediated signaling. Therefore, this mutation disrupts optimal STING trafficking, which inhibits TBK1-mediated IRF3 activation but not NF-κB activation.

Catalog Number: 76293-160

Supplier: Cayman Chemical Company

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BMS 345541 (trifluoroacetate salt) ≥98%

Description: BMS 345541 (trifluoroacetate salt), Purity >/=98%, MF: C14H17N5.2CF3COOH, MW: 483.4, Synonyms: IKK Inhibitor III, N1-(1,8-dimethylimidazo[1,2-a]quinoxalin-4-yl)-1,2-ethanediamine, trifluoroacetate salt, Formulation: crystalline solid, Storage: -20C, Size: 1mg

Catalog Number: 76292-966

Supplier: Cayman Chemical Company

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QNZ ≥98%

Description: QNZ, Purity >/=98%, CAS 545380-34-5, MF: C22H20N4O, MW: 356.4, Synonyms: CAY10470, N4-[2-(4-phenoxyphenyl)ethyl]-4,6-quinazolinediamine, ubiquitous transcription factor that functions to enhance the transcription of pro-inflammatory cytokine, Size: 500ug

Catalog Number: 76293-100

Supplier: Cayman Chemical Company

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Human Recombinant cGAS (from E. coli)

Description: Cyclic GMP-AMP (cGAMP) synthase (cGAS) (161-522) is a truncated form of cGAS (Item No. 22810) that contains the nucleotidyltransferase and Mab21 domains. cGAS is a nucleotidyltransferase located in the cytosol that acts as a cytosolic DNA sensor to detect foreign DNA from microbial pathogens as part of the innate immune response. Upon binding to cytosolic DNA, cGAS produces the cyclic dinucleotide second messenger cGAMP, which activates stimulator of interferon genes (STING), leading to activation of the type I interferon (IFN) pathway. In vitro, fibroblasts, macrophages, and dendritic cells isolated from cGAS knockout (cGAS-/-) mice do not produce type I IFNs following DNA transfection or DNA virus infection. Similarly, cells containing a frame-shift mutation in the cGAS locus fail to mount an immune response to HIV and other retroviruses. In vivo, cGAS-/- mice infected with herpes simplex virus 1 (HSV-1) have lower levels of IFN-α and IFN-β, shorter survival times, and higher post-mortem levels of HSV-1 in the brain.

Catalog Number: 76292-894

Supplier: Cayman Chemical Company

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