You Searched For: PROSCI INCORPORATED

Catalog Number: (10751-104)

Supplier: Prosci

Description: AXIN1 Antibody: AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

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Catalog Number: (76751-260)

Supplier: Prosci

Description: Anti-DKK3 Rabbit Polyclonal Antibody

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Catalog Number: (77127-490)

Supplier: Prosci

Description: TAF9 Peptide

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Catalog Number: (77128-882)

Supplier: Prosci

Description: APOBEC2 Peptide

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Catalog Number: (76629-898)

Supplier: Prosci

Description: Anti-FGB Recombinant Antibody [Clone: 8E5]

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Catalog Number: (76629-640)

Supplier: Prosci

Description: Anti-CD37 Recombinant Antibody [Clone: G28-1]

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Catalog Number: (77125-028)

Supplier: Prosci

Description: FRG1 Peptide

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Catalog Number: (10813-694)

Supplier: Prosci

Description: Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'.

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Catalog Number: (76012-002)

Supplier: Prosci

Description: This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.

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Catalog Number: (89417-806)

Supplier: Prosci

Description: SLAMF1 Antibody: The signaling lymphocyte-activation molecule family member 1 (SLAMF1) is a novel receptor on T cells that potentiates T cell expansion in a CD28-independent manner. SLAMF1 is predominantly expressed by hematopoietic tissues. Reports suggest that the extracellular domain of SLAMF1 is the receptor for the measles virus and acts as a co-activator on both T and B cells. It is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations of the SLAM associated gene may be associated with X-linked lympho-proliferative disease (XLP).

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Catalog Number: (10748-294)

Supplier: Prosci

Description: PHAP Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.

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Catalog Number: (10764-128)

Supplier: Prosci

Description: The BM8.1 monoclonal antibody specifically binds to the Mouse125 kDa F4/80 antigen, expressed by most mature macrophages. F4/80 is a transmembrane protein used as a marker of macrophages, although it is also expressed on Kupffer and Langerhans cells. The expression of F4/80 antigen is upregulated on bone marrow cells stimulated in vitro with the macrophage colony stimulating factor. The F4/80 antigen is a requirement for the induction of CD8 T cells-mediated peripheral tolerance.

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Catalog Number: (75791-224)

Supplier: Prosci

Description: PIGR binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment.

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Catalog Number: (10764-964)

Supplier: Prosci

Description: The 5E8-G9-B4 monoclonal antibody specifically reacts with human CD193, also known as CKR3 and CCR3. CD193. CD193 is a G protein-coupled seven transmembrane receptor that binds to eotaxin-1,2,3 and to a lesser degree to MCP-3,4 and RANTES. It is expressed on eosinophils and basophils, mast cells platelets, CD34+ hematopoietic progenitor, and mononuclear phagocytes. CD193 plays a role in asthma and is a co-receptor for HIV-1,2.

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Catalog Number: (10061-950)

Supplier: Prosci

Description: The Friend leukemia virus integration 1 (FLI1) protein is a transcription factor containing an ETS DNA-binding domain and is highly expressed in hematopoietic cell lineages and vascular endothelial cells. FLI1 plays important roles in megakaryocytic differentiation (2) and vascular homeostasis. The FLI1 gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases.. Abnormal expression of FLI1 can be used as an adverse prognostic indicator for acute myeloid leukemia.

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Catalog Number: (10078-366)

Supplier: Prosci

Description: PLK, a Polo type protein kinase, has been shown to function in mitosis. The mRNA is absent or expressed at very low levels during the G1 phase, begins to reaccumulate during the S phase, and reaches maximal levels during the G2/M phase. PLK1 may participate in targeting MPF to the nucleus during prophase and in regulating mitotic spindle function. These functions, in addition to its expression in proliferating cells, suggest that PLK1 has a role in cancer progression.

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