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Supplier: Adipogen
Description: Interleukin-10 (IL-10) is a cytokine produced by activated Th2 cells, B cells, keratinocytes and monocytes/macrophages. In vitro murine and human IL-10 inhibits cytokine synthesis by Th1 cells, natural killer cells and monocytes/macrophages. Several studies have suggested the potential application of IL-10 as an anti-inflammatory agent in the treatment of septic shock and as an immunosuppressive agent in certain T cell mediated autoimmune diseases.

Catalog Number: (102512-542)
Supplier: Adipogen
Description: Human CD66e is a heavily glycosylated GPI anchored protein capable of heterophilic and homophilic adhesion and may play a role in metastasis of cancer cells. Soluble CD66e is also known as carcinoembryonic antigen (CEA).

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Catalog Number: (102512-536)
Supplier: Adipogen
Description: Human CD66e is a heavily glycosylated GPI anchored protein capable of heterophilic and homophilic adhesion and may play a role in metastasis of cancer cells. Soluble CD66e is also known as carcinoembryonic antigen (CEA).

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Catalog Number: (102971-630)
Supplier: Adipogen
Description: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.


Catalog Number: (102971-576)
Supplier: Adipogen
Description: Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.


Supplier: Adipogen
Description: Acetylcholine esterase and ATPase inhibitor. Ichthyotoxin. Tumorigenesis and JB6 cell transformation inhibitor.

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Supplier: Adipogen
Description: Reference standard.

Supplier: Adipogen
Description: Indolocarbazole alkaloid antibiotic.. Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A). Anticancer compound. Cytotoxic againt various cancer cell lines. Apoptosis inducer. Antiviral compound against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). LACTB (beta-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B, ME1. ME2, ME3) and chymotrypsin inhibitor. Inhibits mixed lineage kinase (MLK).

Supplier: Adipogen
Description: Brain-permeable SIRT2 (sirtuin 2) inhibitor.

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Supplier: Adipogen
Description: GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats.

Supplier: Adipogen
Description: Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. For the stabilization and activation of enzymes.

Supplier: Adipogen
Description: Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro.

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Supplier: Adipogen
Description: Potent fluorescent inhibitor of choline acetyltransferase. CMKLR1 antagonist. Inhibits chemerin-stimulated beta-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration. Aldehyde dehydrogenase 1 (ALDH1A1) antagonist.

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Supplier: Adipogen
Description: Gilvocarcin V is an antibiotic, anti-tumor compound.

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Supplier: Adipogen
Description: IL-23p19 associates with IL-12b to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Supplier: Adipogen
Description: Phytotoxic, antifungal and anthelmintic. Prolyl endopeptidase inhibitor.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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