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Catalog Number: (102513-152)
Supplier: Adipogen
Description: Human CD165 is a cell surface molecule present on a subset of peripheral lymphocytes and monocytes and is important for adhesion of thymocytes to thymic epithelial cells.

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Supplier: Adipogen
Description: Potent inhibitor of human 5-lipoxygenase (5-LO)

Catalog Number: (102513-060)
Supplier: Adipogen
Description: Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting CD8+ cytotoxic cells upon activation.

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Catalog Number: (102512-508)
Supplier: Adipogen
Description: Human CD60 antigen is a glycolipid determinant found on about 30% of peripheral blood T cells. The glycolipid determinant is linked to a glycoprotein which can transduce activation signals.

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Catalog Number: (102512-230)
Supplier: Adipogen
Description: Human CD32 exists in at least six isoforms originating from three different genes (Fc gamma RII A, B, and C). The CD32 molecule is a low affinity receptor for immune complexed IgG and has signal-transducing capabilities involved with humoral and cell-mediated immune responses.

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Catalog Number: (102513-282)
Supplier: Adipogen
Description: Human CD54 (ICAM-1) mediates cell adhesion by binding to the integrins CD11a/CD18 (LFA-1) and to CD11b/CD18 (Mac-1). CD54 expression on resting peripheral blood leukocytes is weak but is upregulated on activated T and B lymphocytes and on monocytes.

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Catalog Number: (102511-750)
Supplier: Adipogen
Description: Human CD80 (B7-1) is a costimulatory ligand for CD28 and CD152 (CTLA-4). CD80 is expressed on activated B cells.

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Catalog Number: (102512-180)
Supplier: Adipogen
Description: Human CD27 is a lymphocyte specific member of the TNF receptor family and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells. The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily.

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Catalog Number: (102512-094)
Supplier: Adipogen
Description: Human CD18 (beta integrin) forms a heterodimer with either alphaL, alphaM, or alphaX integrins (CD11a, b or c). CD11/CD18 heterodimeric molecules are involved with cell/cell and cell/extracellular adhesion in immune and inflammatory responses.

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Catalog Number: (102511-426)
Supplier: Adipogen
Description: Negative control in assays where mouse IgG1 (ATTO 488)-labeled antibodies are used.


Catalog Number: (102981-460)
Supplier: Adipogen
Description: CD28 and CTLA-4 together with their ligands, CD80 (B7-1) and CD86 (B7-2), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD28 and CTLA-4 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD28 and CTLA-4 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2 and mouse chromosome 1. Mouse CD28 is expressed constitutively on virtually 100% of mouse T cells and on developing thymocytes. Cell surface expression of mouse CD28 is downregulated upon ligation of CD28 in the presence of PMA or PHA. In contrast, CTLA-4 is not expressed constitutively but is upregulated rapidly following T cell activation and CD28 ligation. Cell surface expression of mouse CTLA-4 peaks approx.y 48 hours after activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28. CD28/B7 interaction has been shown to prevent apoptosis of activated T cells via the upregulation of bcl-XL. CD28 ligation has also been shown to regulate Th1/Th2 differentiation.


Catalog Number: (102512-294)
Supplier: Adipogen
Description: Human CD38 is a type II transmembrane glycoprotein with bifunctional ectoenzyme activity catalyzing both synthesis and hydrolysis of cyclic ADP ribose. CD38 is involved in lymphocyte activation and adhesion to endothelium and has been identified as a counter-receptor of CD31.

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Catalog Number: (102513-396)
Supplier: Adipogen
Description: CD3 molecules associate with T cell receptors and provide intracellular signaling mechanism.

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Catalog Number: (102511-792)
Supplier: Adipogen
Description: Human immunoglobulins are glycoproteins composed of two disulfide-bonded heavy (H) chain subunits, each of which is linked by interchain disulfide bonds to a light (L) chain forming a tetramolecular complex. There are five classes of immunoglobulins, designated IgG, IgA, IgM, IgD and IgE, which are defined by differences in the constant region of H chains. L chains are divided into kappa or lambda classifications based on structural antigenic differences. All classes of immunoglobulins have been found on the cell surface of B lymphocytes where they function as antigen receptors to elicit antigen-dependent proliferation and secretion of antigen specific soluble circulating antibodies.

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Catalog Number: (102513-012)
Supplier: Adipogen
Description: Human CD44 molecules appear to serve as lymphocyte adhesion molecules with numerous functions in extracellular matrix binding, cell migration, hemopoisis and lymphocyte homing.

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Catalog Number: (102511-400)
Supplier: Adipogen
Description: TRAIL-R2 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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