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Catalog Number: (102971-630)
Supplier: Adipogen
Description: IL-38 (IL-1F10) belongs to the IL-1 family of proteins. IL-38 is expressed in heart, placenta, fetal liver, spleen, thymus and tonsil. The expression in a variety of immune tissues and similarity to IL-1Ra suggest a role of IL-38 as a IL-1 family receptor antagonist. Il-38 inhibits IL-36 signaling by binding to IL-1R6. IL-38 (aa 20-152) is released from apoptotic cells to limit inflammatory macrophage and downstream Th17 activation by blocking IL1RAPL1 (Interleukin-1 receptor accessory protein-like 1, TIGIRR-2) signaling. IL-38 is unregulated during some autoimmune diseases such as Systemic Lupus Erythematosus.


Catalog Number: (102971-576)
Supplier: Adipogen
Description: Notch signaling pathway regulates many different cell fate decisions in both vertebrate and invertebrate species. There are 5 canonical Notch ligands in mammals: Jagged-1, Jagged-2, DLL1, DLL3 and DLL4. These can bind to the four Notch receptors Notch 1-4. It is important for pattern formation during development such as neurogenesis, angiogenesis or myogenesis and regulates T cell development and stem cell maintenance. Notch signaling is also involved in cellular processes through-out adulthood. Signaling via Notch occurs between neighbouring cells and both the receptor and its ligands are transmembrane proteins.


Supplier: Adipogen
Description: Acetylcholine esterase and ATPase inhibitor. Ichthyotoxin. Tumorigenesis and JB6 cell transformation inhibitor.

Small Business Enterprise

Supplier: Adipogen
Description: Reference standard.

Supplier: Adipogen
Description: Indolocarbazole alkaloid antibiotic.. Potent cell permeable reversible and ATP-competitive PKC (protein kinase C) inhibitor with 10-fold selectivity over PKA (protein kinase A). Anticancer compound. Cytotoxic againt various cancer cell lines. Apoptosis inducer. Antiviral compound against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). LACTB (beta-lactamase), malate dehydrogenase (MDH2, MDHC, MDH1B, ME1. ME2, ME3) and chymotrypsin inhibitor. Inhibits mixed lineage kinase (MLK).

Supplier: Adipogen
Description: Brain-permeable SIRT2 (sirtuin 2) inhibitor.

Small Business Enterprise

Supplier: Adipogen
Description: GSK429286A is a potent and selective inhibitor of Rho-associated kinase (ROCK1), with an IC(50) of 14nM. It is orally available and has been shown to dramatically reduce mean arterial pressure in spontaneously hypertensive rats.

Supplier: Adipogen
Description: Non-ionic detergent. For functional solubilization, purification and crystallography of membrane proteins. For the stabilization and activation of enzymes.

Supplier: Adipogen
Description: Cell permeable Sonic hedgehog (Shh) agonist. Cell permeable smoothened (Smo) agonist. Induces Sonic hedgehog (Shh) pathway activation and counteracts cyclopamine inhibition of Smo. Acts as an activator of Smo at low concentrations and as an inhibitor of Smo at very high concentrations. Potent activator of VEGF expression in vitro.

Small Business Enterprise

Supplier: Adipogen
Description: Potent fluorescent inhibitor of choline acetyltransferase. CMKLR1 antagonist. Inhibits chemerin-stimulated beta-arrestin2 association with CMKLR1, as well as chemerin-triggered CMKLR1+ cell migration. Aldehyde dehydrogenase 1 (ALDH1A1) antagonist.

Small Business Enterprise

Supplier: Adipogen
Description: Gilvocarcin V is an antibiotic, anti-tumor compound.

Small Business Enterprise

Supplier: Adipogen
Description: IL-23p19 associates with IL-12b to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 binds to an heterodimeric receptor complex composed of IL-12RB1 and IL-23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Supplier: Adipogen
Description: Phytotoxic, antifungal and anthelmintic. Prolyl endopeptidase inhibitor.

Small Business Enterprise

Catalog Number: (102514-718)
Supplier: Adipogen
Description: Negative control in assays where mouse IgG2b antibodies are used.


Supplier: Adipogen
Description: Zinc(II) specific fluorophores probes.

Supplier: Adipogen
Description: Some cationic mitochondrial dyes such as 4-Di-1-ASP and 4-Di-2-ASP stain presynaptic nerve terminals independent of neuronal activity. The photostable 4-Di-2-ASP dye, which is nontoxic to cells, has been employed to stain living nerve terminals in rabbit corneal epithelium, in rat epidermis and at mouse, snake and frog neuromuscular junctions, as well as to visualize the innervation of the human choroid and whole mounts of the gastrointestinal tract. Methods for using 4-Di-2-ASP to image neuronal cells in live animals have been described (Ex/Em = 488/607 nm).

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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