You Searched For: VWR International

Description: Human CD27 is a lymphocyte specific member of the TNF receptor family and is found primarily on peripheral blood T cells and on a subpopulation of B cells and NK cells. The ligand for CD27 is CD70, which is a member of the TNF ligand superfamily.

Catalog Number: 102512-184

Supplier: Adipogen

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Description: Hexacyclinic acid is an antibiotic, anti-tumor compound.

Catalog Number: 102513-678

Supplier: Adipogen

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Description: CD3 molecules associate with T cell receptors and provide intracellular signaling mechanism.

Catalog Number: 102513-390

Supplier: Adipogen

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Description: Antibodies to human CD17 react with lactosylceramide which is expressed on granulocytes, monocytes, platelets and basophils. CD17 expression is downmodulated on activated granulocytes. CD17 is an important component in CD11b/CD18 mediated phagocytosis of microbes.

Catalog Number: 102512-078

Supplier: Adipogen

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Description: Sirtuin-6 is a NAD-dependent protein deacetylase with activity towards 'Lys-9' and 'Lys-56' of histone H3. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Required for genomic stability and for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. Regulates the production of TNF protein.

Catalog Number: 102514-612

Supplier: Adipogen

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Description: Human CD81 is a member of the tetraspan family of leukocyte cell surface molecules which are involved in signal transduction, cell-cell adhesion and cellular activation. Association of CD81 with integrins appears to be functionally important in the regulation of cell adhesion and activation. Recent work with CD81-null mice indicates CD81 is important for development of humoral immune response.

Catalog Number: 102512-866

Supplier: Adipogen

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Description: Human CD147 (EMMPRIN) is a transmembrane glycoprotein expressed more intensely on thymocytes than on mature peripheral blood T cells. Expression of CD147 in bronchial epithelial cells has been correlated with incidence of COPE.

Catalog Number: 102513-126

Supplier: Adipogen

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Description: Human CD11a (alpha L integrin) complexes with CD18 (beta 2 integrin) to form the LFA-1 heterodimer adhesion molecule which binds to three ICAM’s 1, 2, and 3, also designated CD54, CD102 and CD50 respectively. LFA-1 is expressed on lymphocytes, monocytes and neutrophils and plays a role in cell-cell adhesion.

Catalog Number: 102512-004

Supplier: Adipogen

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Description: Human CD80 (B7-1) is a costimulatory ligand for CD28 and CD152 (CTLA-4). CD80 is expressed on activated B cells.

Catalog Number: 102511-754

Supplier: Adipogen

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Description: Potent and reversible cell permeable Wnt pathway signaling inhibitor. Inhibits Wnt-induced accumulation of beta-catenin, leading to proteasomal degradation of this protein through a destruction complex which consists of Apc, Axin2, CK1 and GSK-3beta. Stabilizes the destruction complex, increasing the level of Axin2 protein without changing the levels of Apc or GSK-3beta. Tankyrase-1 (TNKS1/PARP5a) and Tankyrase-2 (TNKS2/PARP5b) inhibitor (in vitro auto-PARsylation assay).

Catalog Number: 102988-640

Supplier: Adipogen

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Description: Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting CD8+ cytotoxic cells upon activation.

Catalog Number: 102513-064

Supplier: Adipogen

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Description: ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage.

Catalog Number: 102514-516

Supplier: Adipogen

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Description: Human CD62E (E-selectin) is an adhesion molecule expressed on activated endothelium and facilitates recruitment of leukocytes to sights of acute inflammation and immunological events. CD62E has affinity to Lewisx.

Catalog Number: 102512-624

Supplier: Adipogen

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Description: Human CD35 binds complement components C3b, C4b and iC3b and is expressed on erythrocytes, B cells, monocytes, granulocytes and folicular dendritic cells and on subsets of thymocytes. CD35 on erythrocytes mediates clearance of immune complexes.

Catalog Number: 102512-266

Supplier: Adipogen

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Description: Human immunoglobulins are glycoproteins composed of two disulfide-bonded heavy (H) chain subunits, each of which is linked by interchain disulfide bonds to a light (L) chain forming a tetramolecular complex. There are five classes of immunoglobulins, designated IgG, IgA, IgM, IgD and IgE, which are defined by differences in the constant region of H chains. L chains are divided into kappa or lambda classifications based on structural antigenic differences. All classes of immunoglobulins have been found on the cell surface of B lymphocytes where they function as antigen receptors to elicit antigen-dependent proliferation and secretion of antigen specific soluble circulating antibodies.

Catalog Number: 102511-808

Supplier: Adipogen

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Description: HMGB1 was originally discovered as an essential DNA-binding protein for regulating p53, NF-kappaB and other important proteins. It is secreted from activated dentric cells, macrophage and nectrotic cells, and acts as a ligand for RAGE, TLR-2 and TLR-4 expressed on surrounding cells. As a result, HMGB1 activates Rac, CDC42 and NF-kappaB inducing localized innate immunity of damaged tissue, tissue regeneration by recruitment of stem cells and hemostasis by induction of tissue factor expression. HMGB1 is also causative agent of various diseases as it causes localized inflammation such as arteriosclerosis, chronic rheumatoid arthritis and nephritis.

Catalog Number: 102981-554

Supplier: Adipogen

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