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Catalog Number: (102512-024)
Supplier: Adipogen
Description: Human CD11c (alpha X integrin) complexes with CD18 (beta 2 integrin) to form the complement receptor type 4 (CR4) heterodimer which binds to fibrinogen and is involved with monocyte/granulocyte adhesion during inflammatory responses. CD11c expression is restricted to leukocytes mainly of myeloid lineage with highest expression on macrophages.

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Catalog Number: (102512-012)
Supplier: Adipogen
Description: Human CD11a (alpha L integrin) complexes with CD18 (beta 2 integrin) to form the LFA-1 heterodimer adhesion molecule which binds to three ICAM’s 1, 2, and 3, also designated CD54, CD102 and CD50 respectively. LFA-1 is expressed on lymphocytes, monocytes and neutrophils and plays a role in cell-cell adhesion.

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Supplier: Adipogen
Description: Labeling of cell-surface functional groups (glycophorins). Detection of protein carbonyls in aging tissues.

Catalog Number: (102513-062)
Supplier: Adipogen
Description: Human perforin (cytolysin) is believed to be one of the major effector molecules used by cytotoxic T cells and NK cells to mediate targeted cell lysis. Perforin expression is constitutive on NK cells, but increases in resting CD8+ cytotoxic cells upon activation.

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Catalog Number: (102513-130)
Supplier: Adipogen
Description: Human CD161 is a homodimeric disulfide-linked type II membrane bound glycoprotein found mainly on NK cells. CD161 has been implicated in the regulation of NK cell mediated cytotoxicity.

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Catalog Number: (102513-098)
Supplier: Adipogen
Description: Human CD137 ligand is a type II transmembrane protein constitutively expressed by monocytes, B cells neuroblastoma cells, and some activated T cells. The interaction of CD137 (4-1BB) and CD137L can supply a costimulatory signal to T cells through CD137. The interaction can also effect a reverse signal, inducing monocyte activation, or T cell inactivation and programmed death through CD137L.

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Catalog Number: (102512-328)
Supplier: Adipogen
Description: Human CD41 is a member of a major platelet transmembrane glycoprotein complex (CD41/CD61) which mediates platelet aggregation and adhesion by serving as the receptor for fibrinogen and von Willebrand factor, fibronectin and vitronectin.

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Catalog Number: (102513-270)
Supplier: Adipogen
Description: Human CD252 (CD134L; OX40 ligand) is a type II membrane protein with homology to TNF which is expressed on activated B cells and activated endothelial cells. CD252 binds to CD134 present on activated T cells, providing a costimulatory signal. Blockade of this interaction in mouse abrogated immunological effects in several models of inflammation and rejection. CD252-muCD8 fusion protein binds to CD134 positive cells in flow cytometry.

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Catalog Number: (102987-224)
Supplier: Adipogen
Description: Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor. Interleukin-1 (IL-1) inhibitor. Anti-osteoarthritic. Potential anti-Alzheimer agent.


Supplier: Adipogen
Description: Oxidoreductase inhibitor. Antitrypanosomal, antibacterial, antifungal, insecticidal and pesticidal. Antitumor compound.

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Catalog Number: (102987-842)
Supplier: Adipogen
Description: Non-toxic, pH-sensitive fluorescent dye (blue-green range) for live imaging of pH alteration in acidic organelles, vesicles, cells, tissue and even small whole animals over several days without side effects. Stronger fluorescent intensity under acidic conditions and barely detectable in alkaline solutions (wide range from pH 4 to pH 8). Highly cell/membrane permeable. Trapped within the cells and acidic organelles through hydrophobic interactions with the inner side of the membranes. Barely metabolized and long-term stable, thus slow photobleaching. Angiogenesis inhibitor. Inhibitor of matrix metalloproteinases MMP-1,-2,-8,-9,-12,-13. TYK2, DYRK2,Dyrk1A, YSK4 and RPS6KA1/2 inhibitor.


Catalog Number: (102515-590)
Supplier: Adipogen
Description: Insulin-growth factor-like gene family is a new family of proteins consisting of four proteins in humans (IGFL1 to 4) and one in mice (mIGFL). mIGFL is expressed in normal skin in mice and further upregulated during inflammation responses in skin or after skin wounding. In human only IGFL1 expression is increased in psoriatic skin samples. mIGFL and human IGFL1 and 3 interact with specificity and high affinity to a novel receptor named IGF-like family receptor 1 (formerly TMEM-149). Analysis of the amino acid sequence of IGFLR1 indicated that this receptor is likely a novel member of the TNF-R family. IGFLR1 is expressed most abundantly on mouse T cells, suggesting that mIGFL and IGFL1 produced in the skin may potentially exert regulatory functions on T cell responses.

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Supplier: Adipogen
Description: A glycolytic intermediate formed by the isomerization of glucose-6-phosphate.

Catalog Number: (102512-360)
Supplier: Adipogen
Description: Human CD45 is expressed on all cells of hematopoietic origin, except erythrocytes. CD45 is a transmembrane tyrosine phosphatase which can exist in at least nine different isoforms resulting from tissue-specific alternative RNA splicing of exons 4-7 of a single gene coding for the various N-terminal peptide segments. The CD45RO isoform contains none of the alternatively spliced exons and is present on most thymocytes, a subpopulation of resting (memory) T cells within both CD4 and CD8 subsets as well as on monocytes and granulocytes. CD45RO plays an essential role in lymphocyte activation.

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Catalog Number: (102989-210)
Supplier: Adipogen
Description: A synthetic intermediate.


Catalog Number: (102512-158)
Supplier: Adipogen
Description: Expression of human CD25 (the alpha subunit of the IL-2 receptor complex) is dramatically upregulated on activated T cells, B cells, NK cells and macrophages. Antibodies to CD25 are being studied for potential use as an immunodirected therapy to selectively attack (kill) CD25 expressing cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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