You Searched For: Van Der Voort Lucht en Milieu Amste

Supplier: Adipogen

Description: BMS-540215 is an ATP-competitive inhibitor of human VEGFR-2, with an IC(50) of 25nM and Ki of 26nM. BMS-540215 also showed good selectivity for FGFR-1 (IC(50) of 48nM), FGFR-2 (IC(50) of 125nM), and FGFR-3 (IC(50) of 68nM).

Catalog Number: (102511-372)

Supplier: Adipogen

Description: TGF-beta1 (Transforming growth factor beta 1) is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. In humans, TGF-beta1 is encoded by the TGFB1 gene. TGF-beta1 was first identified in human platelets as a protein with a molecular mass of 25 kaD with a potential role in wound healing. It was later characterized as a large protein precursor (containing 390 aa) that was proteolytically processed to produce a mature peptide of 112 aa. TGF-beta1 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages. Most immune cells (or leukocytes) secrete TGF-beta1.

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Supplier: Adipogen

Description: 6-HEX is an amino-conjugatable fluorescent probe that is widely used in nucleic acid sequencing and related research. It can also be used to label peptides and oligonucleotides.

Catalog Number: (102988-286)

Supplier: Adipogen

Description: Potent, irreversible inhibitor of all the 3 proteolytic activities of the mammalian 20S proteasome. beta5 subunit: chymotrypsin-like (EC50 = 3.5nM) beta2 subunit: trypsin-like (EC50 = 28nM) beta1 subunit: caspase-like or peptidyl-glutamyl peptide-hydrolyzing (PGPH) (EC50 = 430nM) Potent anticancer compound. Triggers apoptosis, with distinct proteasome activity and mechanism of action compared to bortezomib (Velcade) . Most potent suppressor of NF-kappaB activation, compared with bortezomib, MG-132 , N-acetyl-leucyl-leucyl-norleucinal (ALLN) and lactacystin . Inhibitor of TNF-alpha, IL-1, IL-6, ICAM-1 and VEGF synthesis. Displays a longer inhibition duration than bortezomib. Potent antileukemic activity against bortezomib-resistant leukemia cells.

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Catalog Number: (102514-300)

Supplier: Adipogen

Description: TRAIL-R1 is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.

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Supplier: Adipogen

Description: Class of highly photostable, water soluble fluorescent labels with large Stoke′s shift, high QY in aqueous media and pH tolerance. Relatively low extinction coefficient (Epsilon∼ <gt/>20,000 in EtOH).

Catalog Number: (102512-318)

Supplier: Adipogen

Description: Human CD40 is a member of the TNF receptor family and is present on all B cells except plasma cells. CD40 is also found on some epithelial cells, carcinomas and lymphoid dendritic cells. CD40 plays an important role in B cell activation and the interaction with its ligand CD154 (CD40 ligand) is essential for isotype switching.

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Supplier: Adipogen

Description: Potent, reversible and cell permeable proteasome inhibitor. Specifically inhibits the chymotrypsin-like activity of the proteasome. Calpain and cathepsin inhibitor. Apoptosis inducer in Rat-1 and PC12 cells via a p53-dependent pathway. Autophagy activator.

Catalog Number: (102511-760)

Supplier: Adipogen

Description: Human MHC Class I (HLA-A, B & C) molecules are expressed on nearly all nucleated cells. MHC Class I molecules consist of heterodimers of a highly polymorphic transmembrane alpha chain and an invariant beta chain. MHC Class I molecules bind to endogenously synthesized peptides of about 8-10 amino acids which are presented to CD8+ T cells. Evidence indicates exogenously derived peptides are also presented by MHC Class I molecules.

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Supplier: Adipogen

Description: Synthetic methylxanthine metabolite of pentoxifylline. Potent anti-inflammatory agent in which only the (−) optical isomer is biologically active. Inhibits the generation of phosphatidic acid from cytokine-activated lysophosphatidic acyl transferase (LPAAT), which has been shown to protect mice from endotoxic shock. Decreases lipid peroxidation in vitr oand in vivo. Suppresses the production of the proinflammatory cytokine IFN-gamma, inhibits IL-12-mediated STAT-4 activation, enhances glucose-stimulated beta-cell insulin secretion, reducing the onset of diabetes in a non-obese diabetic mouse model, and blocks autoimmune deterioration of pancreatic beta cells in non-obese diabetic mice. Compound can be used as analytical reference material.

Supplier: Adipogen

Description: Anticancer compound. Orally active, potent and selective colony stimulating factor 1 receptor (CSF-1R; c-Fms) inhibitor. More than 1000-fold selective against its closest receptor tyrosine kinase homologs c-KIT and platelet-derived growth factor receptor beta (PDGFRbeta). Selective against more than 200 additional kinases.

Supplier: Adipogen

Description: Carboxyfluorescein is commonly employed as a polar tracer and used for intracellular pH measurements. It has also been used for studying viability of various types of bacteria.

Catalog Number: (102988-354)

Supplier: Adipogen

Description: Chirality inducing agent. Useful tool as resolving agent to separate the isomers and purify racemic mixtures (e.g. DL-lysine) by fractionally crystallizing the product to obtain the pure isomer (e.g. L-lysine). Can also be used as building block. Insect repellent. Stimulator of osteoblast differentiation.

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Supplier: Adipogen

Description: Fluorogenic dealkylase substrate for the measurement of the cytochrome-mediated monooxygenase or "mixed function" oxidase system.

Catalog Number: (102981-458)

Supplier: Adipogen

Description: CD27 (TNFRSF7) is a member of the TNF-receptor superfamily limited to cells of the lymphoid lineage and exists as both a dimeric glycoprotein on the cell surface and as a soluble protein in serum. As a T and B cell co-stimulatory molecule, the activity of CD27 is governed by its TNF-like ligand CD70 on lymphocytes and dendritic cells. The CD27-CD70 interaction is required for Th1 generation responses to differentiation signals and long-term maintenance of T cell immunity, and meanwhile, plays a key role in regulating B cell differentiation, activation and immunoglobulin synthesis. The CD27 receptor transduces signals and subsequently leads to the activation of NF-kappaB and MAPK8/JNK, mediated by the adaptor proteins TRAF2 and TRAF5. In addition, the proapoptotic protein SIVA is capable of binding the cytoplasmic tail of CD27 and exerts action in the process of apoptosis.

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Catalog Number: (102514-362)

Supplier: Adipogen

Description: The inflammasome is a multiprotein complex that mediates the activation of caspase-1, which promotes, amongst others, the secretion of the proinflammatory cytokines interleukin (IL)-1beta and IL-18. Members of the Nod-like receptor (NLR) family are critical components of the inflammasome that link danger-signals to caspase-1 activation. The NLR member IPAF/NLRC4 senses bacterial flagellin and a conserved type III secretion system (TTSS) rod component. A member of the NLR family, NAIP5 directly and specifically interacts with flagellin, triggers a physical NAIP5-NLRC4 association leading to NLRC4 activation. The related NAIP2 functions analogously to NAIP5, serving as a specific inflammasome receptor for TTSS rod proteins such as Salmonella PrgJ and Burkholderia BsaK.

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