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Anti-TCR Monoclonal Antibody (Biotin) [clone: Jovi-1]

Catalog Number: (102511-732)
Supplier: Adipogen
Description: Human T cell receptor (TCR) is a T cell surface expressed heterodimer of alpha/beta or gamma/delta chains. TCR’s recognize antigen peptides bound to MHC molecules forming the basis of antigen specific response by T cells.

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Anti-CD30 Monoclonal Antibody (Biotin) [clone: AC10]

Catalog Number: (102512-212)
Supplier: Adipogen
Description: Human CD30 is a member of the TNF receptor family and is expressed on mitogen activated B and T cells.

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Mouse IgG3 Isotype Control [clone: SIPC 3385] (SIPC 3385) (R-PE)

Catalog Number: (102512-826)
Supplier: Adipogen
Description: Immunoglobulin expressed by the mouse plasmacytoma hybridoma SIPC 3385 is an IgG3 isotype of unknown specificity. It is used as a negative control when working with human cells.

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AMG-25 ≥95%

Supplier: Adipogen
Description: AMG-25 exhibits potent inhibition of c-Kit with greater than 200-fold selectivity over KDR, p38, Lck and Src.

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AQC ≥95% (by NMR)

Supplier: Adipogen
Description: Suitable for amino acid or protein sequence analysis by HPLC with fluorescence detection.

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Rubrofusarin ≥98% (by HPLC)

Supplier: Adipogen
Description: Monomer of aurofusarin. Mycotoxin. Anticancer and antimycobacterial compound in vivo. Moderate tyrosinase inhibitor. Anti-estrogenic.

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LY-333,531 hydrochloride ≥98% (by HPLC)

Supplier: Adipogen
Description: Isozyme selective inhibitor of protein kinase Cbeta (PKCbeta). PKCbetaI and PKCbetaII isozyme inhibitor. Amelioriates diabetic retinopathy, diabetic peripheral neuropathy and diabetic nephropathy. Anti-cancer and anti-angiogenic compound. Suppresses glucose-induced adhesion of human monocytes to endothelial cells. Suppresses ERK1/2 and Akt phosphorylation.

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Mouse Recombinant Angiopoietin (from HEK293 cells)

Supplier: Adipogen
Description: Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) are closely related secreted ligands which bind with similar affinity to Tie-2. Tie-2 and angiopoietins have been shown to play critical roles in embryogenic angiogenesis and in maintaining the integrity of the adult vasculature. Ang-1 activates Tie-2 signaling on endothelial cells to promote chemotaxis, cell survival, cell sprouting, vessel growth and stabilization. Ang-2 has been identified as a secreted protein ligand of Tie-2 and has alternatively been reported to be an antagonist for Ang-1 induced Tie-2 signaling as well as an agonist for Tie-2 signaling, depending on the cell context.

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Anti-ACVR2B Rabbit Polyclonal Antibody

Catalog Number: (102979-988)
Supplier: Adipogen
Description: Activin Receptor IIB (ACTR-IIB) is a transmembrane receptor that forms an activin receptor complex with activin type-1 receptors (ACVR1, ACVR1B or ACVR1c). ACTR-IIB transduces the activin signal from the cell surface to the cytoplasm and regulates therefore many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary.
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NIR 4d ≥98% (by HPLC)

Supplier: Adipogen
Description: Near-infrared (near-IR, NIR) fluorescent dye. Near-infrared (near-IR, NIR) dyes offer important advantages over traditional visible light dyes. Because cellular or tissue components produce minimal autofluorescence in the near-IR region, near-IR dyes have the potential to offer highly specific and sensitive detection in complex biological systems. Also, because light with wavelength in the near-IR region has strong tissue penetration, near-IR dyes are ideal for in vivo fluorescence imaging, an emerging field that has advanced rapidly in recent years. Max. absorbance: 809nm

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PF-4618433 ≥95%

Supplier: Adipogen
Description: Potent and selective PYK2 inhibitor. PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796. In the functional osteogenesis assays, cultures treated with increasing concentrations of PF-4618433 starting at day 1 and maintained throughout showed a dose-dependent increases in both alkaline phosphatase activity and mineralization.

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GCI1746 ≥95%

Supplier: Adipogen
Description: CGI1746 was identified as a selective and potent ATP-competitive BTK inhibitor with an IC(50) of 1.9nM. It is specific for BTK, with around 1000-fold selectivity over Tec and Src family kinases.

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BX-912 ≥95%

Supplier: Adipogen
Description: BX912 is a PDK1 (3-Phosphoinositide-dependent Kinase-1) inhibitor, with an IC(50) of 26nM.

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Fingolimod

Supplier: Adipogen
Description: Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer.

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Eosin-5-isothiocyanate ≥98% (by HPLC)

Supplier: Adipogen
Description: Fluorescent probe. Long wavelength red labeling derivative for proteins. Can be used as a reversible inhibitor of the erythrocyte calcium pump as well as an effective phosphorescent probe in measurement of rotational diffusion of proteins and in fluorescence energy transfer (FRET) studies. EITC tagged molecules may be used together with fluorescein-5′-isothiocyanate (FITC) tagged molecules in fluoresce resonance energy transfer (FRET) based assays. Spectral properties: Abs/Em = 520/544 nm

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beta-Mannosylceramide ≥95% (by TLC, NMR)

Supplier: Adipogen
Description: Potent stimulator of invariant natural killer T (iNKT) cells. Induces strong antitumor immunity through a nitric oxide (NO) and TNF-alpha dependent mechansim, different compared to the IFN-gamma dependent mechanism of alpha-GalCer (AG-CN2-0014). Does not induce anergy of iNKT cells.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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