You Searched For: Helvolic acid

Description: Fluorescent dye. Fluorophore standard that is widely used in enzyme assay systems. Precursor for a variety of R110-based enzyme substrates for flow cytometric measurements. Used as a calibration standard for R110-based enzyme substrates. Compared to AMC and AFC enzyme substrates, fluorogenic R110 substrates are generally more sensitive, giving longer absorption and fluorescence wavelength than AMC and AFC substrates. Spectral data: lambdaex 498nm| lambdaem 520nm in methanol.

Catalog Number: 102990-914

Supplier: Adipogen

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Description: Aranciamycin is a clostridium histolyticum collagenase inhibitor

Catalog Number: 102513-800

Supplier: Adipogen

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Description: Fluorescent stain for DNA.

Catalog Number: 102989-412

Supplier: Adipogen

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Description: Antifungal. Anticancer compound. Cytotoxic to human cancer cell lines.

Catalog Number: 102987-412

Supplier: Adipogen

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Description: The human CD3/T cell receptor (TcR) complex is made up of the CD3 proteins (gamma, delta, 2 epsilon) and teh zeta-chain in association with either alpha/beta or gamma/delta proteins of the TcR. The TcR recognizes antigens in association with MHC molecules after which protein chains of the CD3 complex mediate activation signals triggered by TcR antigen binding. CD3 is expressed on greater than 95% of circulating human peripheral T cells.

Catalog Number: 102511-864

Supplier: Adipogen

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Description: RANKL is an osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T cell proliferation. Important regulator of interactions between T cells and dendritic cells and may play a role in the regulation of the T cell-dependent immune response. RANKL plays an important role in the progression of breast cancer.

Catalog Number: 102980-110

Supplier: Adipogen

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Description: Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages and a subset of granulocytes. CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein. A soluble form of CD14 also binds to LPS and LBP.

Catalog Number: 102512-052

Supplier: Adipogen

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Description: Human CD152 (CTLA-4) is a cell surface glycoprotein expressed at low levels on activated T cells. CD152 is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2) and appears to function as a negative regulator of T cell activation. This product is a soluble fusion protein combining the extracellular (125aa) domain of human CD152 and murine IgG2a Fc (CTLA-4 Ig).

Catalog Number: 102513-212

Supplier: Adipogen

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Description: Tamatinib effectively inhibits BCR signaling in vivo, resulting in reduced proliferation and survival of the malignant B cells and significantly prolonged survival of the treated animals.

Catalog Number: 102992-190

Supplier: Adipogen

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Description: Shows strong gastrointestinal motor stimulating (GMS) activity. Motilin receptor agonist. Stimulates smooth muscle cell contraction. Stimulates cholinergic neurons in a non-vagal pathway. Enhances gastrointestinal contractile activity and accelerates gastric emptying. Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor).

Catalog Number: 102987-344

Supplier: Adipogen

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Description: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Catalog Number: 102980-098

Supplier: Adipogen

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Description: Building block for synthesis.

Catalog Number: 102989-970

Supplier: Adipogen

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Description: Human CD70 is not present on resting lymphocytes. CD70 is expressed after activation on about 20% of T cells and on about 70% of B cells. CD70 is a ligand for CD27 and it is also a member of the TNF gene family.

Catalog Number: 102512-554

Supplier: Adipogen

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Description: TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Catalog Number: 102515-538

Supplier: Adipogen

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Description: Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Apoptosis inducer. Potent antiproliferative agent in malignant lymphoid cell. Antimetastatic agent. Potent chemosensitizing agent fighting TRAIL resistant cancer cells.

Catalog Number: 102516-096

Supplier: Adipogen

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Description: Human CD22 expression is restricted to normal Ig+ mature B cells and neoplastic B cells. CD22 is a transmembrane glycoprotein of 140kDa with a predicted adhesion molecule function.

Catalog Number: 102512-134

Supplier: Adipogen

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