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Human Recombinant IL-4

Supplier: Stemcell Technologies

Description: Human Interleukin 4 (IL-4) is important for immune responses to helminth infection as well as in allergic responses (Olpihant et al.). The IL-4 receptor consists of a heterodimer of IL-4Ra and common gamma chain. IL-4 receptor engagement leads to the activation of JAK1/3 and the recruitment of STAT6 and IRS1/2 (Nelms et al.). IL-4 drives immunoglobulin class switching in B cells (to IgE, IgG4), mast cell hyperplasia, mucus production, and the differentiation of naïve T cells into Th2 cells, which produce IL-4, IL-5, IL-10, and IL-13 (Bao et al.; Nelms et al.; Olpihant et al.). In addition to Th2 cells, IL-4 is produced by CD4+ NK T cells, γ/δ T cells, activated basophils, eosinophils, and mast cells. Human IL-4 does not cross-react with mouse cells (Park et al.).

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STEMdiff™ Mesoderm Induction Medium

Catalog Number: (MSPP-05221)

Supplier: Stemcell Technologies

Description: Defined, xeno-free induction medium for early mesodermal differentiation.

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MegaCult™-C Collagen and Medium with Cytokines

Catalog Number: (MSPP-04961)

Supplier: Stemcell Technologies

Description: Kit containing collagen and medium with cytokines for human CFU-Mk assays.

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Human Recombinant FGF-9

Catalog Number: (MSPP-781611006)

Supplier: Stemcell Technologies

Description: Fibroblast growth factor (FGF) 9 is a pleiotropic member of the FGF family. FGFs are heparin-dependent regulators of cell proliferation and differentiation (Itoh and Ornitz). FGF-9 signals by binding FGFR3 (IIIb) and the IIIc splice variants of the FGFR1, FGFR2, and FGFR3 receptors (Santos-Ocampo et al.; Mohammadi et al.; Plotnikov et al.). In mice, deletion of FGF-9 is lethal and expression of FGF-9 affects development of the skeleton, cerebellum, lungs, heart, vascular system, digestive tract, and testes (Colvin et al.; Harada et al.; Lin et al.). Altered levels of FGF-9 have also been reported in various types of human cancers (Leushacke et al.; Abdel-Rahman et al.).

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EasyPlate™ EasySep™ Magnet

Catalog Number: (MSPP-18102)

Supplier: Stemcell Technologies

Description: The EasyPlate™ EasySep™ Magnet is designed for cell separation procedures using selected EasySep™ reagents when processing a small number of cells (up to 2×10⁷ cells per well).

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STEMdiff™ Motor Neuron Maturation Kit

Catalog Number: (MSPP-100-0872)

Supplier: Stemcell Technologies

Description: Differentiation and maturation kits for generation of motor neurons from human pluripotent stem cells.

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EasySep™ Human Central and Effector Memory CD8+ T Cell Isolation Kit

Catalog Number: (MSPP-17869)

Supplier: Stemcell Technologies

Description: Immunomagnetic positive selection of human central and effector memory CD8+ T cells.

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Human Recombinant NT-4

Catalog Number: (MSPP-78093)

Supplier: Stemcell Technologies

Description: Neurotrophin-4 (NT-4) is a member of the nerve growth factor family which includes neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF), all of which promote the differentiation, growth, and survival of peripheral and central nervous system neurons (Eide et al.). NT-4 binds and activates tropomyosin receptor kinase B (TrkB) at the cell surface; in doing so, it acts as a survival factor for certain populations of sensory neurons (Berkemeier et al.; Skaper). It has been shown that NT-4, together with BDNF, promotes neurite extension and maturation, as well as maintenance of differentiated cerebellar granule cells (Gao et al.).

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EasySep™ Human B Cell Isolation Kits

Supplier: Stemcell Technologies

Description: Immunomagnetic isolation of untouched human B cells.

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Human Recombinant IGF-I

Supplier: Stemcell Technologies

Description: Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).

Mouse Recombinant IL-6

Supplier: Stemcell Technologies

Description: Interleukin 6 (IL-6) is a pleiotropic growth factor with a wide range of biological activities in immune regulation, hematopoiesis, and oncogenesis. IL-6 is produced by a variety of cell types including T cells, B cells, monocytes and macrophages, fibroblasts, hepatocytes, vascular endothelial cells, and various tumor cell lines. On its own or in combination with other factors such as IL-2 and interferon-γ, IL-6 stimulates the proliferation of B cells, T cells, and hybridoma cells (Nordan et al.; Van Snick et al.; Gauldie et al.; Mihara et al.; Tanaka et al). In combination with cytokines such as IL-3, GM-CSF, and SCF, IL-6 has been shown to promote hematopoietic progenitor cell proliferation and differentiation in vitro. IL-6 signals through a cell surface type I cytokine receptor complex consisting of the ligand-binding IL-6α (CD126) and the signal-transducing gp130 subunits. The binding of IL-6 to its receptor system includes activation of the JAK/STAT signaling pathway (Mihara et al.; Peters et al; Tanaka et al.).