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Anti-CD44 Rat Monoclonal Antibody [clone: IM7]

Supplier: Stemcell Technologies

Description: Rat monoclonal IgG2b antibody against human, mouse, rhesus CD44 (tissue non-specific alkaline phosphatase), unconjugated.

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Anti-SSEA-4 Mouse Monoclonal Antibody [clone: MC-813-70] (Biotin)

Catalog Number: (MSPP-60062BT)

Supplier: Stemcell Technologies

Description: Mouse monoclonal IgG3 antibody against human, mouse, rat SSEA-4, biotin-conjugated.

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Anti-CD150 (SLAM) Rat Monoclonal Antibody [clone: TC15-12F12.2] (Alexa Fluor® 488)

Supplier: Stemcell Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD150 (SLAM), Alexa Fluor® 488-conjugated.

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Anti-Vimentin Mouse Monoclonal Antibody [clone: 1A7]

Catalog Number: (MSPP-100-1065)

Supplier: Stemcell Technologies

Description: Mouse monoclonal antibody against human, mouse, rat vimentin.

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Anti-CD19 Rat Monoclonal Antibody [clone: 1D3] (PE)

Supplier: Stemcell Technologies

Description: Rat monoclonal IgG2a antibody against mouse CD19, PE-conjugated.

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Human Recombinant Fetuin B, His tag

Catalog Number: (MSPP-100-1333)

Supplier: Stemcell Technologies

Description: Fetuin B is thought to have functions in female fertility, metabolism, and liver disease. A protease inhibitor belonging to the fetuin family of proteins, within the cystatin superfamily, fetuin b’s structure includes two cystatin domains (CY1 and CY2) connected by a linker, with a CPDCP-trunk and a C-terminal region (CTR) (Cuppari et al.). This plasma protein originates in the liver (Denecke et al.) and acts to inhibit the activity of ovastacin, a metalloprotease that causes the zona pellucida to harden, leading to female infertility (Karmilin et al.). Fetuin B has also been reported to increase apoptosis, and inhibit migration and invasion of prostate cancer cells, in in vitro and in vivo settings (Zhan et al.). Elevated serum fetuin B has been linked to non-alcoholic fatty liver disease (NAFLD) (Zhu et al.). This protein contains a His-residue tag at the carboxyl end of the polypeptide chain. For consistency and reproducibility across your applications, apolipoprotein H from STEMCELL comes lyophilized with ≥ 92% purity, and is verified by LAL analysis to ensure endotoxin levels are ≤1.0 EU/μg protein.

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Human Recombinant G-CSF, ACF

Supplier: Stemcell Technologies

Description: Granulocyte colony-stimulating factor (G-CSF) is a member of the CSF family of glycoproteins that regulate hematopoietic cell proliferation, differentiation, and function. It is a key cytokine involved in the production of neutrophils and the stimulation of granulocyte colony formation from hematopoietic progenitor cells (Metcalf and Nicola). G-CSF causes a range of effects including a transient reduction of SDF-1 expression (Petit et al.), the activation of metalloproteases that cleave VCAM-1 (Levesque et al.), and the release of norepinephrine from the sympathetic nervous system (Katayama et al.), leading to the release or mobilization of hematopoietic stem cells from the bone marrow into the periphery. The G-CSF receptor is expressed on a variety of hematopoietic cells, including myeloid-committed progenitor cells, neutrophils, granulocytes, and monocytes. In addition to hematopoietic cells, G-CSF is also expressed in cardiomyocytes, neuronal cells, mesothelial cells, and endothelial cells. Binding of G-CSF to its receptor leads to activation of the JAK/STAT, MAPK, PI3K, and AKT signal transduction pathways. This product is animal component-free.

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Anti-CD11c Hamster (Armenian) Monoclonal Antibody [clone: N418] (PE)

Supplier: Stemcell Technologies

Description: Hamster (Armenian) monoclonal IgG antibody against mouse CD11c.

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Mouse Recombinant IL-11

Supplier: Stemcell Technologies

Description: Interleukin 11 (IL-11) is a pleiotropic cytokine with effects on various tissues including the bone marrow, brain, and intestinal mucosa (Du and amp; Williams). It belongs to the IL-6 family of cytokines that share a common signal transducer, gp130. Culture of mouse bone marrow cells with IL-11 in combination with IL-3, IL-6, and stem cell factor induces significant expansion and proliferation of colony-forming cells in vitro (Peters et al.). In addition, in combination with IL-3, IL-11 significantly enhances the growth of megakaryocytic colonies in vitro, suggesting its role in augmenting mouse megakaryopoiesis (Yonemura et al.). IL-11 is expressed in a wide range of normal adult mouse tissues, including the central nervous system, thymus, lung, and bone. The mouse IL-11 cDNA was cloned using an expression library generated from the lipopolysaccharide-induced mouse fetal thymic cell line, T2 (Morris et al.). The binding of IL-11 to its receptor induces heterodimerization with the gp130 subunit and activation of JAK tyrosine kinases. IL-11 also plays a role in cancer progression by inducing the proliferation of epithelial cancer cells and the survival of metastatic cells at distant organs. Recently, IL-11 has gained interest for its role in the pathogenesis of diseases in dysregulated mucosal homeostasis associated with STAT3 upregulation, including gastrointestinal cancers (Putoczki et al.).

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Human Recombinant Shh (C24II)

Supplier: Stemcell Technologies

Description: Sonic hedgehog (Shh) is a member of the Hedgehog family of secreted signaling proteins that has a prominent role in patterning during early mammalian development (Ho and Scott). It is expressed during early embryogenesis in a variety of tissues (Finco et al.). During patterning of the central nervous system, Shh directly acts on cells to specify neural cell fates, regulates proliferation and survival of oligodendrocytes precursors and neural crest cells and stimulates proliferation, differentiation and axon growth (Ho and Scott; Martí). Shh also regulates T cell differentiation and activation (Crompton et al.). Recombinant human Shh (C24II; rhShh) is a fully biologically active molecule.

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