You Searched For: OPTEM

Catalog Number: (100243-272)

Supplier: Southern Biotechnology

Description: CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e. B220+/CD43+/HSA+) through fully differentiated B cell stages. Terminally differentiated plasma cells do not express CD19. In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. Studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. The monoclonal antibody 6D5 recognizes the same epitope as the published clone, 1D3.

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Catalog Number: (103265-254)

Supplier: Southern Biotechnology

Description: CD49d, a member of the integrin family of extracellular matrix and cell adhesion molecules, is the integrin α4 chain. CD49d associates noncovalently with CD29, the integrin β1 subunit, to form the α4β1 very late antigen-4 (VLA-4) heterodimer. Integrin α4 can also associate with integrin β7 to form the α4β7 heterodimer. It is expressed on most leukocytes with the possible exception of neutrophils. VLA-4 mediates leukocyte binding to CD106 (VCAM-1) and is involved in the migration of leukocytes from blood to tissue at sites of inflammation. VLA-4 can also provide a costimulatory signal to T cells for activation and proliferation. The α4β7 integrin heterodimer is expressed on a small subpopulation of thymocytes, most lymph node T and B lymphocytes, NK cells, and eosinophils. Integrin α4β7 also binds to fibronectin and VCAM-1.

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Catalog Number: (100245-870)

Supplier: Southern Biotechnology

Description: CD9 is a 24 kDa member of the transmembrane 4 superfamily (TM4-SF) of cell surface receptors. It is expressed strongly on platelets, lymphoid progenitor cells, activated lymphocytes and endothelia, and, weakly, on eosinophils, granulocytes, monocytes, and macrophages. CD9 functions as an adhesion molecule where it mediates platelet aggregation and activation.

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Catalog Number: (100243-590)

Supplier: Southern Biotechnology

Description: CD62L, also known as L-selectin, is a type I transmembrane glycoprotein with lectin-like and epidermal growth factor-like domains. It binds to sialylated oligosaccharide determinants on high endothelial venules (HEV) in peripheral lymph nodes. In the mouse, CD62L is expressed on most thymocytes and on peripheral leukocytes, including B and T lymphocytes, neutrophils, monocytes, and eosinophils. This member of the selectin family of cell adhesion molecules appears to be required for lymphocyte homing to peripheral lymph nodes and for leukocyte extravasation at sites of inflammation. Expression of CD62L on lymphocytes and neutrophils is rapidly down-regulated upon cell activation and the level of CD62L expression, along with other markers, distinguishes naive T cells from effector/memory T cells. The monoclonal antibody MEL-14 blocks in vitro binding of lymphocytes to peripheral lymph node HEV and inhibits in vivo lymphocyte extravasation into peripheral lymph nodes and the late stages of leukocyte rolling.

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Catalog Number: (103264-744)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Human IgM-HRP antibody for use in ELISA, immunocytochemistry, and ELISpot assays.

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Catalog Number: (100242-974)

Supplier: Southern Biotechnology

Description: Purified Anti-Type IV Collagen antibody for use in ELISA, immunohistochemistry / immunocytochemistry, electron microscopy, flow cytometry, western blotting, and immunoprecipitation assays.

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Supplier: Southern Biotechnology

Description: Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR) and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRαβ+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice, but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.

Catalog Number: (100244-262)

Supplier: Southern Biotechnology

Description: Goat Anti-Human IgG-FITC antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.

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Catalog Number: (100244-828)

Supplier: Southern Biotechnology

Description: Porcine CD3ε is a member of the T-cell receptor-associated CD3 complex. It is found on a subpopulation of thymocytes and on all pig T lymphocytes. The monoclonal antibody PPT3 is mitogenic when presented to peripheral blood mononuclear cells in immobilized form.

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Catalog Number: (100245-610)

Supplier: Southern Biotechnology

Description: Chicken CD44 is a type I transmembrane glycoprotein expressed on many cell types including B cells, most T cells, monocytes, and some epithelial cells. CD44 primarily functions as an adhesion molecule. It has been implicated in various processes such as hematopoiesis, lymphocyte homing, leukocyte activation, tumor metastasis, and development. The monoclonal antibody AV6 also reacts with turkey peripheral blood mononuclear cells.

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Supplier: Southern Biotechnology

Description: Protein G, Buffer Formulation Supplied lyophilized from distilled water; No BSA, preservatives or amine-containing buffer salts added, Store at -20 deg C, Applications: ELISA, Size: 5.0 mg

Catalog Number: (100245-766)

Supplier: Southern Biotechnology

Description: Purified Anti-Human IgA2 antibody for use in ELISA, flow cytometry, immunohistochemistry, western blotting, ELISpot, separation, depletion, and multiplex assays.

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Supplier: Southern Biotechnology

Description: Cell Staining Buffer maximizes fluorescent signal intensity generated by pH sensitive fluorochromes.

Catalog Number: (100244-306)

Supplier: Southern Biotechnology

Description: Goat F(ab')2 Anti-Human IgG-Biotin antibody with minimal reactivity to mouse proteins for use in ELISA and flow cytometry assays.

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Catalog Number: (100244-412)

Supplier: Southern Biotechnology

Description: Goat Anti-Rat Ig-TRITC antibody with minimal reactivity to mouse proteins for use in immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (100245-526)

Supplier: Southern Biotechnology

Description: Purified Anti-Chicken IgA antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, and immunoprecipitation assays.

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