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Catalog Number: (100244-108)

Supplier: Southern Biotechnology

Description: The monoclonal antibody 34-5-8S reacts with a conformational epitope on H-2Dd MHC Class I found on the N-terminal domains of α1 and α2 chains when complexed with β2-microglobulin. The antibody does not react with H-2Dd α chains synthesized in vitro. Weak cross-reactivity with cells from mice of the H-2b, H-2q, and H-2s haplotypes has been observed by flow cytometric analysis. Reactivity with cells from mice of the H-2f, H-2k, H-2p, and H-2r haplotypes has not been observed. 34-5-8S has been reported to block the recognition of H-2Dd by Ly-49A+, Ly-49C+, and Ly-49G2+ natural killer cells.

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Catalog Number: (103264-954)

Supplier: Southern Biotechnology

Description: Goat Anti-Canine IgG(H+L)-Alexa Fluor 488 antibody for use in immunohistochemistry / immunocytochemistry and western blotting assays.

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Catalog Number: (100243-678)

Supplier: Southern Biotechnology

Description: CD90 (Thy-1), a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily of cell surface receptors, consists of a single V-set domain. It is expressed on thymocytes, peripheral T lymphocytes, some intraepithelial T lymphocytes, and neurons of all mouse strains. The monoclonal antibody G7 stimulates T-cell proliferation and IL-2 secretion via signaling through the T-cell receptor/CD3 complex. G7 has also been reported to promote apoptosis of thymocytes and CTL clones and to mediate adhesion of thymocytes to thymic stroma.

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Catalog Number: (100241-998)

Supplier: Southern Biotechnology

Description: Low Endotoxin/Azide Free Mouse IgG for use as a control in flow cytometry, immunohistochemistry / immunocytochemistry, western blotting, immunoprecipitation, ChIP, and in vivo / in vitro assays and as a standard in ELISA.

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Catalog Number: (103259-854)

Supplier: Southern Biotechnology

Description: AP Anti-Mouse IgG2b antibody for use in ELISA,, immunocytochemistry, and western blotting assays.

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Catalog Number: (103259-864)

Supplier: Southern Biotechnology

Description: Purified Anti-Mouse IgG3 antibody for use in ELISA and flow cytometry assays.

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Catalog Number: (103265-582)

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse Lambda-Alexa Fluor 555 antibody for use in immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (100243-812)

Supplier: Southern Biotechnology

Description: The CD45 antigen is an essential regulator of leukocyte activation and development and is now known to be a protein tyrosine phosphatase, e.g., CD45 is able to dephosporylate the Src family of protein kinases. This activity is known to be required for signal transduction induced by T and B cell antigen receptor engagement, cytokine signaling, and Fc receptor stimulation. The functional state of CD45 also has a pronounced effect on lymphocyte development. CD45 exists in multiple forms, such as the restricted variants (CD45R; see companion products 1660, 1665, 1675, 1685 and 1820) and as allelic forms CD45.1 (Ly-5.1) and CD45.2 (Ly-5.2). The specificity of antibodies to CD45.1 and CD45.2 has been exploited in studies where resolution of donor and recipient cells is essential, such as in gene therapy or bone marrow transplantation. The monoclonal antibody 104 recognizes CD45 (leukocyte common antigen) on all leukocytes of mouse strains expressing the CD45.2 allotype (e.g., A, AKR, BALB/c, CBA/Ca, CBA/J, C3H/He, C57BL, C57BR, C57L, C58, DBA/1, DBA/2, NZB, SWR, 129).

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Catalog Number: (103264-542)

Supplier: Southern Biotechnology

Description: CD4 is a type I transmembrane glycoprotein expressed on most thymocytes and the helper/inducer subpopulation of mature T lymphocytes of all mouse strains tested. CD4 has also been detected at low density on pluripotent hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic lymphoid precursors. The CD4 antigen functions as a co-receptor, interacting with class II major histocompatability complex (MHC) molecules in the recognition of foreign antigens by T cells. In vivo and in vitro treatment with the GK1.5 monoclonal antibody effectively depletes CD4+ cells. GK1.5 also blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.

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Catalog Number: (100243-428)

Supplier: Southern Biotechnology

Description: The lymphocyte Fcγ receptors recognize the Fc portion of IgG, presented either as immune complexes or as free antibody. The different classes of receptors are distinct because of varying size, tissue distribution and affinity for IgGs. The Fc type II receptor is expressed on a wide variety of cells including B cells, hematopoietic cells, monocyte/macrophages, neutrophils, platelets, Langerhans cells, eosinophils, basophils, trophoblasts, and endothelial cells of the placenta. The Fcγ type III receptors are higher affinity than the type II and are expressed on macrophages, NK cells and neutrophils. Both types of receptors can be expressed on the same cell and in varying ratios. The receptors are constitutively expressed, although cytokines and lymphokines can modulate their expression. Besides identifying FcγR+ cells, monoclonal antibodies to the FcγII/III receptor have been used to block Fc receptor binding of IgG, Fc-mediated signal transduction and effector functions, clearance of immune complexes and to attenuate infection by organisms dependent on FcγR for parasitic invasion. The monoclonal antibody 93 recognizes a conformational epitope formed by FcγII and FcγIII receptors.

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Catalog Number: (100244-826)

Supplier: Southern Biotechnology

Description: Porcine CD3ε is a member of the T-cell receptor-associated CD3 complex. It is found on a subpopulation of thymocytes and on all pig T lymphocytes. The monoclonal antibody PPT3 is mitogenic when presented to peripheral blood mononuclear cells in immobilized form.

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Catalog Number: (103265-146)

Supplier: Southern Biotechnology

Description: CD3 is a member of the T cell receptor-associated CD3 complex. The monoclonal antibody CT-3 recognizes a complex of at least three polypeptides of Mr 20, 19, and 17 kDa (two of which are N-glycosylated) on chicken T cells. The antibody also coprecipitates a polypeptide of 90 kDa from digitonin solubilized T cell lysates, which can be reduced to two polypeptides of Mr 50 and 40 kDa.

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Catalog Number: (103260-100)

Supplier: Southern Biotechnology

Description: Purified Rabbit Anti-Hamster IgG(H+L) antibody with minimal reactivity to mouse and rat serum proteins for use in ELISA, flow cytometry, immunohistochemistry, and western blotting assays.

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Catalog Number: (100242-296)

Supplier: Southern Biotechnology

Description: Purified Anti-Human IFN-gamma antibody for use in flow cytometry, immunohistochemistry / immunocytochemistry, ELISA, ELISpot, immunoprecipitation, and multiplex assays.

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Catalog Number: (103259-952)

Supplier: Southern Biotechnology

Description: CD90 (Thy-1) is a GPI-anchored molecule and one of the smallest members of the immunoglobulin superfamily consisting of a single V-set domain. The Thy-1.2 alloantigen is expressed on all thymocytes, peripheral T lymphocytes, and some intraepithelial T cells of most mouse strains. It is also expressed in the brain and at varying levels on other non-lymphoid tissues. The 30-H12 monoclonal antibody does not cross react with mouse and rat strains bearing the Thy-1.1 alloantigen (e.g., AKR/J, PL).

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Catalog Number: (100246-118)

Supplier: Southern Biotechnology

Description: CD8 is a 33 kDa transmembrane glycoprotein expressed as either a CD8αα homodimer or CD8αβ heterodimer. It is expressed on the “cytotoxic/suppressor” subpopulation of peripheral T cells. CD8 functions primarily as a coreceptor with MHC class I-restricted TCR’s in antigen recognition.

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