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Catalog Number: (100244-102)
Supplier: Southern Biotechnology
Description: The “classical” MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic α chains noncovalently associated with the invariant β2-microglobulin. These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. The monoclonal antibody 34-1-2S binds to a common determinant in the α3 domains of H-2Kd and H-2Dd in the presence or absence of β2 microglobulin. It cross reacts with the α3 domain of H-2Kb.


Catalog Number: (103260-042)
Supplier: Southern Biotechnology
Description: Purified Goat Anti-Human IgG Fc antibody with minimal reactivity to mouse, bovine, and horse serum proteins for use in ELISA assays.


Catalog Number: (103260-046)
Supplier: Southern Biotechnology
Description: Goat Anti-Human IgG Fc-HRP antibody with minimal reactivity to mouse, bovine, and horse serum proteins for use in ELISA assays.


Catalog Number: (103264-450)
Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgG2c-Biotin antibody for use in ELISA assays.


Catalog Number: (103264-628)
Supplier: Southern Biotechnology
Description: The αβ TCR is expressed on T lymphocytes of all mouse strains tested. The H57-597 monoclonal antibody does not react with γδ TCR-bearing cells. Plate-bound or soluble H57-597 activates αβ TCR-bearing T cells. In vitro and in vivo, H57-597 can induce immature thymocytes to undergo apoptosis. In vivo administration of H57-597 has been shown to deplete αβ TCR-bearing cells to near completion and prevent graft rejection.


Catalog Number: (100243-620)
Supplier: Southern Biotechnology
Description: CD69, also known as very early activation (VEA) antigen, is a disulfide-linked transmembrane homodimer whose differentially glycosylated subunits range from 35-39 kDa. It is a C-type lectin most closely related to the NKR-P1 and Ly-49 NK cell-activation molecules. CD69 is widely expressed on hematopoietic cells, including lymphocytes, neutrophils and eosinophils. Although not detectable on resting lymphocytes, its expression is rapidly upregulated upon activation of T, B and NK cells, and neutrophils. Constitutive expression of CD69 on subsets of thymocytes suggests that it may be involved in regulation of developmental events in addition to its role in activation of a variety of hematopoietic cells. The monoclonal antibody H1.2F3 augments PMA-induced T-cell proliferation and induces redirected lysis of Fc receptor-bearing target cells by NK cells.


Catalog Number: (100244-942)
Supplier: Southern Biotechnology
Description: Purified Rabbit F(ab')2 Anti-Goat IgG(H+L) antibody for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.


Catalog Number: (103265-238)
Supplier: Southern Biotechnology
Description: HRP Anti-Human Kappa antibody for use in ELISA assays.


Catalog Number: (100244-450)
Supplier: Southern Biotechnology
Description: Goat Anti-Rat IgM-Biotin antibody for use in ELISA, flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.


Catalog Number: (103259-782)
Supplier: Southern Biotechnology
Description: Purified Goat Anti-Mouse IgG2a antibody for use in ELISA, immunohistochemistry / immunocytochemistry, and western blotting assays.


Catalog Number: (103265-308)
Supplier: Southern Biotechnology
Description: CD11c is a 150 kDa adhesion glycoprotein that associates with β2 integrin to form the CD11c/CD18 heterodimer that binds CD54 (ICAM-1) and fibrinogen. It is expressed on NK cells, a subset of B and T cells, granulocytes, monocytes, and macrophages. It functions in cytotoxic T cell killing and in neutrophil and monocyte adhesion to endothelium.


Catalog Number: (100246-310)
Supplier: Southern Biotechnology
Description: CD51 represents the integrin αV chain that associates with integrin β3 (CD61) to form the CD51/CD61 vitronectin receptor on endothelial cells, certain activated leukocytes, NK cells, macrophages, neutrophils, and platelets. CD51 is the most promiscuous integrin α subunit as it can form heterodimers with the β1 (CD29), β3 (CD61), β5, β6 and β8 subunits in various tissues. CD51/CD61 acts as an activation-independent receptor for platelet attachment and spreading on vitronectin and other RGD-containing proteins including matrix components. It also mediates leukocyte-endothelial cell adhesion via interaction with CD31.


Catalog Number: (100245-120)
Supplier: Southern Biotechnology
Description: Rabbit Anti-Sheep IgG(H+L)-FITC antibody for use in immunohistochemistry / immunocytochemistry and western blotting assays.


Catalog Number: (103264-886)
Supplier: Southern Biotechnology
Description: Goat Anti-Rabbit IgG(H+L)-HRP antibody with minimal reactivity to mouse, rat, and human proteins for use in ELISA assays.


Catalog Number: (103264-596)
Supplier: Southern Biotechnology
Description: CD54, a member of the immunoglobulin superfamily of cell surface receptors and also known as Intercellular Adhesion Molecule-1 (ICAM-1), is a type I transmembrane glycoprotein that mediates important cell/cell interactions. CD54 is expressed on endothelial cells, dendritic cells, keratinocytes, and lymphocytes. Its expression is upregulated by inflammatory mediators such as IFN γ, IL-1, TNF-α, lipopolysaccharide, and phorbol esters. Endothelial CD54 contributes to the extravasation of leukocytes from blood vessels, particularly in areas of inflammation. CD54 on antigen-presenting cells contributes to antigen-specific T-cell activation, presumably by enhancing interactions between T cell and antigen-presenting cells. These adhesion reactions are mediated via the binding of CD54 to its major ligands, LFA-1 and Mac-1.


Catalog Number: (101442-674)
Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgG3-APC/CY7 antibody with minimal reactivity to human proteins for use in flow cytometry assays.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
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