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Catalog Number: (101442-588)

Supplier: Southern Biotechnology

Description: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1-8). The two keratin types share only 30% sequence homology. Keratins demonstrate tissue- and differentiation-specific expression profiles. Cytokeratin 19 is the smallest human keratin. It is found in many simple and some non-keratinizing stratified squamous epithelia and is often co-expressed with keratin 7. Cytokeratin 19 has been implicated as a marker for stem cells in some tissues such as hair follicles in the skin. Monoclonal antibodies to cytokeratin proteins can be useful markers for tumor identification and classification. The degree of cytokeratin 19 positivity in breast cancer distinguishes malignant from benign tumors. Cytokeratin 19 is also associated with malignant transformation in esophageal and pancreatic cancers.

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Catalog Number: (103260-022)

Supplier: Southern Biotechnology

Description: Goat Anti-Human Lambda-AP antibody with minimal reactivity to mouse proteins for use in ELISA assays.

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Catalog Number: (100244-626)

Supplier: Southern Biotechnology

Description: FITC Anti-Rat IgM antibody for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (100245-666)

Supplier: Southern Biotechnology

Description: PE/CY5 (SPRD) Anti-Human IgM antibody for use in flow cytometry assays.

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Catalog Number: (100246-398)

Supplier: Southern Biotechnology

Description: CD95, also known as Fas and APO-1, is a 45 kDa type I transmembrane glycoprotein and a member of the tumor necrosis factor receptor superfamily. It is expressed by activated lymphocytes, monocytes, neutrophils, fibroblasts, and cell lines. Fas ligand binding to CD95 induces apoptosis in activated mature lymphocytes thereby playing a role in maintaining peripheral tolerance. Crosslinking of CD95 by the monoclonal antibodies DX2 and DX3 delivers an apoptotic signal to Fas-sensitive cells indicating that these monoclonal antibodies recognize a functional epitope of CD95.

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Catalog Number: (100243-706)

Supplier: Southern Biotechnology

Description: Ly-6A/E, also known as Sca-1, is a member of the Ly-6 multigene family of type V glycophosphatidylinositol-anchored cell surface proteins. It is expressed on multipotent hematopoietic stem cells in bone marrow of mice with both the Ly-6.1 and Ly-6.2 allotypes. In the periphery, Ly-6A/E exhibits a pattern of expression which is based on differences between the two allotypes. Ly-6.1 strains (e.g., A, BALB/c, CBA, C3H/He, DBA/1, NZB) have few Ly-6A/E+ resting peripheral lymphocytes whereas Ly-6.2 strains (e.g., AKR, C57BL, C57BR, C57L, DBA/2, PL, SJL, SWR, 129) have relatively high numbers of Ly-6A/E+ lymphocytes. The expression of Ly-6A/E is dramatically upregulated in all strains upon cellular activation. Studies with the monoclonal antibody D7 suggest that Ly-6A/E may be involved in B and T lymphocyte responses and it appears that the antigen may be required for T-cell receptor-mediated T-cell activation.

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Catalog Number: (100243-222)

Supplier: Southern Biotechnology

Description: CD11b (integrin αM subunit) combines with CD18 (integrin β2 subunit) to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1 (CD54). Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils.

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Catalog Number: (100243-472)

Supplier: Southern Biotechnology

Description: Murine CD38, a type II transmembrane glycoprotein, is a bifunctional ectoenzyme capable of catabolizing nicotinamide adenine dinucleotide (NAD+) to cyclic ADP-ribose (cADPR), and then hydrolyzing cADPR to adenosine diphosphoribose (ADPR). It is expressed at high levels on the surface of peripheral B-lineage cells and at low density on germinal center B cells from unimmunized mice. It has also been reported to be expressed at moderate levels on NK cells, a proportion of peripheral T cells, and a subpopulation of thymocytes which are mostly TCRαβ+, CD4-, CD8-. Murine CD38 is also expressed by all Mac-1+ macrophages in the peritoneal cavities of unimmunized mice but not by unstimulated bone-marrow-derived macrophages. Monoclonal antibodies to CD38 have been shown to induce B and T cell proliferation, protect B cells from apoptosis, and inhibit B lymphopoiesis.

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Catalog Number: (100244-810)

Supplier: Southern Biotechnology

Description: The monoclonal antibody 2C4 reacts with RLA-DQ-transfected cells, but not with RLA-DR-transfected cells. In normal adult rabbits, the antibody reacts with 30-60% of peripheral blood leukocytes. It has also been reported that the antibody stains lymphocytes and macrophages in the spleen, lymphocytes in the thymic medulla and some cells in the cortex, Kupffer cells in the liver, and synovial lining cells (e.g., infiltrating macrophages) in inflamed synovium. DQα transcripts have been detected in bone marrow and spleen and to a lesser extent in appendix, lymph nodes, and other organs.

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Catalog Number: (100244-930)

Supplier: Southern Biotechnology

Description: Rabbit F(ab')2 Anti-Sheep IgG(H+L)-AP antibody for use in ELISA and immunohistochemistry assays.

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Catalog Number: (101190-266)

Supplier: Southern Biotechnology

Description: Purified Anti-Human TLR2 antibody for use in flow cytometry assays.

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Catalog Number: (100245-652)

Supplier: Southern Biotechnology

Description: Purified Anti-Human IgM antibody for use in ELISA, flow cytometry, western blotting, and stimulation assays.

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Catalog Number: (100243-528)

Supplier: Southern Biotechnology

Description: CD45R, also known as B220, a member of the protein tyrosine phosphate family and a major cell surface glycoprotein, represents a restricted form of the CD45 family which primarily recognizes only cells of B-lineage from pro-B cell through mature B lymphocytes and prior to the availability of anti-CD19 monoclonal antibodies was commonly used as a pan B-cell marker. It also reacts with certain activated T cells as well as non-MHC-restricted lytically active lymphokine-activated killer (LAK) cells. In vivo administration of RA3-6B2 has been shown to affect differentiation of both T and B cells in normal mice and reduce the level of anti-DNA antibodies and lymphadenopathies in MRL/lpr mice.

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Catalog Number: (103265-346)

Supplier: Southern Biotechnology

Description: CD16, a member of the immunoglobulin superfamily, is a 50-65 kDa glycoprotein found as both a transmembrane and GPI-linked form. The transmembrane form of CD16 is expressed on NK cells, granulocytes, macrophages, and mast cells but not on eosinophils. The GPI-anchored type of CD16 is found only on neutrophils. CD16 is involved in NK activation and signal transduction.

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Catalog Number: (100242-322)

Supplier: Southern Biotechnology

Description: Goat F(ab’)2 Anti-Mouse Ig-AP antibody with minimal reactivity to human proteins for use in ELISA, immunocytochemistry, western blotting, and ELISpot assays.

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Catalog Number: (100244-084)

Supplier: Southern Biotechnology

Description: The 695H1-9-9 antibody reacts with a Qa-2-determined alloantigen. It recognizes an epitope distinct from that recognized by monoclonal antibody 1-1-2.

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