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Catalog Number: (100241-902)

Supplier: Southern Biotechnology

Description: Mouse IgG1-PE/CY5 (SPRD) for use as a control in flow cytometry assays.

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Catalog Number: (100245-570)

Supplier: Southern Biotechnology

Description: Chicken Bu-1a, a product of the Bu-1a allele, is expressed on the cell surface as a disulfide-linked homodimer. In 10-week-old H.B15 and H.B2 chickens, Bu-1 is found on 85-90% of bursal cells, 2-8% of thymocytes, 15-27% of spleen cells, and 2-18% of peripheral blood cells. It is also expressed on subsets of macrophages and monocytes but not on granulocytes, erythrocytes, or thrombocytes. In chickens heterozygous for the Bu-1 alleles (Bu-1a/b), Bu-1a does not exhibit allelic exclusion. The monoclonal antibody 21-1A4 does not react with cells from CHA and H.B14ab strains by immunofluorescence.

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Catalog Number: (100243-028)

Supplier: Southern Biotechnology

Description: CD106, also known as VCAM-1, is an adhesion molecule and a major mediator of the inflammatory response. It is expressed on activated microvascular endothelial cells in response to signals arising from immune responses in infection, graft rejection, tumor recognition and killing. The complementary binding ligand for VCAM-1 is VLA-4/CD49d. In addition to VCAM-1, VLA-4 also recognizes the extracellular matrix molecule fibronectin. This pairing of VCAM-1 and VLA-4 is able to provide a second signal (e.g., non-antigen specific) for T cell stimulation, such as that seen in transplantation. The monoclonal antibody MK-2 has been used in transplant studies to suppress cardiac rejection and induce long-term cardiac graft survival. In addition to inflammatory responses, VCAM-1 has a significant role in hemopoiesis through its ability to retain lymphocyte and myeloid precursors on stromal cells in the marrow and lymphoid organs. CD106/VCAM-1 exists as an integral membrane protein. The M/K-2 monoclonal antibody immunoprecipitates a peptide that gives a single band on SDS-PAGE gels with an apparent Mr of ~100 kDa under reducing conditions and 92 kDa under non-reducing conditions.

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Catalog Number: (101442-710)

Supplier: Southern Biotechnology

Description: Glial fibrillary acid protein (GFAP) is a member of the type III intermediate filament family of proteins. GFAP is heavily expressed in astrocytes and certain other astroglia in the central nervous system, in satellite cells in peripheral ganglia, and in non-myelinating Schwann cells in peripheral nerves. It is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and functions of the cell’s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cell; however, its precise function remains poorly understood. In adults, GFAP levels increase in response to the proliferation of astrocytes associated with Alzheimer’s disease, epilepsy, and multiple sclerosis. Antibodies specific for GFAP are useful as markers of astrocytic cells and neural stem cells as well as for distinguishing neoplasms of astrocytic origin from other neoplasms in the central nervous system.

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Catalog Number: (100242-402)

Supplier: Southern Biotechnology

Description: Purified Anti-Mouse IL-5 antibody for use in immunohistochemistry / immunocytochemistry, ELISA, ELISpot, and purification assays.

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Catalog Number: (100242-698)

Supplier: Southern Biotechnology

Description: Goat F(ab’)2 Anti-Mouse IgG2a-FITC antibody with minimal reactivity to human proteins for use in flow cytometry and immunohistochemistry / immunocytochemistry assays.

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Catalog Number: (100245-852)

Supplier: Southern Biotechnology

Description: HRP Anti-Human IgE antibody for use in ELISA, ELISpot, and western blotting assays.

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Catalog Number: (103265-064)

Supplier: Southern Biotechnology

Description: Donkey Anti-Mouse IgG(H+L)-Alexa Fluor 488 antibody with minimal reactivity to human, goat, sheep, bovine, rabbit, chicken, horse, and guinea pig serum proteins for use in immunocytochemistry assays.

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Catalog Number: (100242-036)

Supplier: Southern Biotechnology

Description: Goat F(ab’)2 IgG-PE/CY5 (SPRD) for use as a control in flow cytometry assays.

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Catalog Number: (103264-786)

Supplier: Southern Biotechnology

Description: Goat Anti-Human IgG-HRP antibody with minimal reactivity to rhesus and cynomolgus proteins for use in ELISA assays.

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Catalog Number: (103264-688)

Supplier: Southern Biotechnology

Description: PE Anti-Hamster IgG2/IgG3 antibody for use in flow cytometry assays.

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Catalog Number: (103265-338)

Supplier: Southern Biotechnology

Description: CD16, a member of the immunoglobulin superfamily, is a 50-65 kDa glycoprotein found as both a transmembrane and GPI-linked form. The transmembrane form of CD16 is expressed on NK cells, granulocytes, macrophages, and mast cells but not on eosinophils. The GPI-anchored type of CD16 is found only on neutrophils. CD16 is involved in NK activation and signal transduction.

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Catalog Number: (100246-282)

Supplier: Southern Biotechnology

Description: CD45RA is a 220 kDa exon A-dependent isoform of CD45. It is expressed on 40-50% of CD4+ peripheral T cells, 50% of peripheral CD8+ T cells, and a portion of B lymphocytes and monocytes.

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Catalog Number: (100246-026)

Supplier: Southern Biotechnology

Description: CD106, also known as INCAM-110, is a 110 kDa vascular adhesion cell adhesion molecule-1 (VCAM-1) that is member of the immunoglobulin superfamily. CD106 is expressed predominantly on cytokine-activated vascular endothelium but has also been identified on interfollicular dendritic cells, some macrophages, and bone marrow stromal cells. Endothelial CD106 binds the integrins α4β1 (CD49d/CD29, VLA-4) and α4β7 and contributes to extravasation of lymphocytes, monocytes, basophils, and eosinophils (but not neutrophils) from blood vessels, particularly at sites of inflammation. Unlike the β2 integrins, the CD106-VLA-4 interaction can mediate both the initial tethering and rolling of lymphocytes on endothelium as well as their subsequent arrest and firm adhesion. CD106 expressed on non-vascular tissues has been implicated in the interaction of hematopoietic progenitors with bone marrow stromal cells, B cell binding to follicular dendritic cells, costimulation of T cells, and embryonic development. The monoclonal antibody 1.G11B1 inhibits in vitro binding of lymphocytes and monocytes to VCAM-1 on stimulated endothelium.

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Supplier: Southern Biotechnology

Description: PE Anti-Mouse IgD antibody for use in flow cytometry assays.

Supplier: Southern Biotechnology

Description: Goat Anti-Mouse IgG(H+L)-APC antibody with minimal reactivity to human proteins for use in flow cytometry assays.