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Catalog Number: (103259-658)
Supplier: Southern Biotechnology
Description: Interleukin-25 (IL-25), also known as interleukin-17E (IL-17E), is a 17 kDa protein and member of the IL-17 cytokine family. This cytokine is secreted by a variety of cells including type 2 helper T cells (Th2), bone marrow-derived mast cells, and alveolar macrophages. On target cells, IL-25 can induce the production of several type 2 cytokines including IL-4, IL-5, and IL-13 and implicates a role for this cytokine in type 2 immune response. Studies have linked this cytokine in promoting airway hyperreactivity, limiting pro-inflammatory cytokine production and chronic intestinal inflammation, and providing protective immunity following intestinal helminth infection.


Catalog Number: (100242-810)
Supplier: Southern Biotechnology
Description: PE/CY7 Anti-Mouse IgM antibody for use in flow cytometry assays.


Catalog Number: (100241-956)
Supplier: Southern Biotechnology
Description: Mouse IgG3-Biotin for use as a control in flow cytometry and immunocytochemistry assays.


Catalog Number: (100244-766)
Supplier: Southern Biotechnology
Description: Goat Anti-Rabbit IgG(H+L)-FITC antibody with minimal reactivity to mouse and human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.


Catalog Number: (100242-232)
Supplier: Southern Biotechnology
Description: Bcl-xL is a 29 kDa member of the Bcl-2 family of proteins involved in regulation of programmed cell death, or apoptosis. It is found in both soluble and membrane fractions of cellular lysates. Like Bcl-2, Bcl-xL has been demonstrated to block apoptosis which is induced by a variety of stimuli and, under certain conditions, offers greater protection against apoptosis than Bcl-2. While formation of heterodimers with the apoptosis-enhancing protein, Bax does not block the apoptosis-suppressing property of Bcl-xL, heterodimerization with Bad effectively inhibits the protective function of Bcl-xL.


Catalog Number: (100243-406)
Supplier: Southern Biotechnology
Description: CD30 is a type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily of proteins. Murine CD30 is expressed predominantly in the thymus and it is inducible in mouse splenocytes stimulated with pokeweed mitogen or concanavalin A. In anti-CD3ε-activated spleen cells, CD30 is expressed primarily on the surface of CD8+ T cells with peak expression on days 4 and 5. Stimulation of CD30+ CTL lines with plate-bound anti-CD30 directly signals IL-5 but not IFN-γ production. While these studies demonstrate that CD30 directs cytokine secretion and suggest that CD30 may play a pivotal role in the pattern of cytokine production by T cells, the precise roles of CD30 and its ligand (CD153) in T-cell development have not been clearly defined.


Catalog Number: (100242-020)
Supplier: Southern Biotechnology
Description: Goat IgG-Biotin for use as a control in flow cytometry and immunohistochemistry / immunocytochemistry assays.


Catalog Number: (100243-300)
Supplier: Southern Biotechnology
Description: CD22, also known as Lyb-8, is a heterodimeric transmembrane glycoprotein and a member of a structurally related group of immunoglobulin (Ig) superfamily domain-containing proteins called the sialoadhesin family. It is detected in the cytoplasm early in B cell development (late pro-B cell stage), appears on the cell surface concomitant with IgD, and is found on most IgM+IgD+ mature B lymphocytes. Expression is lost with terminal differentiation of B cells and is absent on plasma cells. Activation of B cells via cross-linking of surface Ig increases CD22 expression. CD22 associates with the B cell receptor (BCR) complex and mediates intercellular adhesion. Its intracellular domain is phosphorylated after antigen receptor cross-linking and is involved in negative regulation of B cell activation.


Catalog Number: (100243-786)
Supplier: Southern Biotechnology
Description: CD152, also known as CTLA-4, is homologous to the costimulatory molecule CD28. Like CD28, the CD152 molecule binds the family of B7 counter-receptors (CD80 and CD86) on antigen-presenting cells. CTLA-4 is not expressed on resting T lymphocytes but is induced 2-3 days following T cell stimulation via the T cell receptor (TCR) complex. Whereas CD28 provides a positive costimulatory signal, CD152 is a negative regulator of T-cell activation, possibly by inhibiting tyrosine kinase signaling through the TCR through its association with tyrosine phosphatases such as SHP-2.


Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgM-APC antibody with minimal reactivity to human proteins for use in flow cytometry assays.

Catalog Number: (103264-906)
Supplier: Southern Biotechnology
Description: Goat Anti-Rabbit IgG(H+L)-FITC antibody for use in fluorescent assays.


Catalog Number: (100242-506)
Supplier: Southern Biotechnology
Description: Goat Anti-Mouse IgG(H+L)-Texas Red antibody with minimal reactivity to human proteins for use in flow cytometry, immunohistochemistry / immunocytochemistry, and western blotting assays.


Catalog Number: (100242-988)
Supplier: Southern Biotechnology
Description: Protein tyrosine residues are phosphorylated as a result of intracellular protein kinase activation (e.g., via growth factors) during normal growth and development and in oncogenesis. The most abundant population of target proteins for tyrosine phosphorylation is cell surface glycoproteins. Antibodies to phosphotyrosine enable the detection, isolation, and characterization of proteins containing phosphotyrosine. The monoclonal antibody PY20 prevents internalization of activated receptors (e.g., EGFR) when microinjected into cells. The affinity of PY20 for phosphotyrosine is approximately 10-6 to 10-7 M. PY20 binding to phosphorylated tyrosines can be inhibited by free phosphotyrosine and phenylphosphate but not by phosphoserine, phosphothreonine, or free phosphate.


Catalog Number: (103265-202)
Supplier: Southern Biotechnology
Description: Alexa Fluor 647 Anti-Human IgG2 Fd antibody for use in flow cytometry, immunohistochemistry, and western blotting assays.


Supplier: Southern Biotechnology
Description: CD9 is a 24 kDa member of the transmembrane 4 superfamily (TM4-SF) of cell surface receptors. It is expressed strongly on platelets, lymphoid progenitor cells, activated lymphocytes and endothelia, and, weakly, on eosinophils, granulocytes, monocytes, and macrophages. CD9 functions as an adhesion molecule where it mediates platelet aggregation and activation.

Catalog Number: (100245-082)
Supplier: Southern Biotechnology
Description: Rabbit F(ab')2 Anti-Rat IgG(H+L)-FITC antibody for use in immunohistochemistry / immunocytochemistry and western blotting assays.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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The original product is no longer available. The replacement shown is available.
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