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Description: CD66, pan Monoclonal antibody, Clone: C66/195 + C66/261 + C66/1009 + C66/1030, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: biotin, Immunogen: Recom full-length human CEA, Synonyms: CEACAM5, CD66, Application: IF, Size: 500 uL

Catalog Number: 75915-642

Supplier: Biotium

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Description: This antibody recognizes keratin 5 (58 kDa) and keratin 8 (52.5 kDa). Simple epithelia express cytokeratin 8 in combination with 18. On the other hand, basal cells of stratified epithelia express cytokeratin 5 paired with 14. This antibody therefore, reacts with a wide range of epithelia and their carcinomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Catalog Number: 75919-924

Supplier: Biotium

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Description: CD43 Monoclonal antibody, Clone: DF-T1, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF488A, Immunogen: Myeloblastic KG1 cells, Synonyms: GALGP, GPL115, Application: IF, IHC, FC, Size: 500 uL

Catalog Number: 75895-958

Supplier: Biotium

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Description: CD10 Monoclonal antibody, Clone: FR4D11, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: BSA-free, Immunogen: Raji cellsUnigene 307734, Application: Immunofluorescence, Flow cytometry, Size: 50 uL

Catalog Number: 75885-628

Supplier: Biotium

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Description: Expression of NKX2.2 has been found in neuroendocrine tumors of the gut, making it a potential marker for the study of gastrointestinal neuroendocrine tumors. More recently, NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Catalog Number: 75966-238

Supplier: Biotium

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Description: SUMO-2, Monoclonal antibody, Clone: SUMO2/1199, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, Conjugate: biotin, Immunogen: Recombinant human SUMO2 protein, Application: Immunofluorescence, Immunohistology (formalin), Flow cytometry, Size: 100uL

Catalog Number: 75974-522

Supplier: Biotium

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Description: Anti-PNL2 is a novel monoclonal antibody, which has recently been introduced as an immunohistochemical reagent to stain melanocytes and tumors derived therefrom. The antigen recognized by PNL2 is different from Melan A and gp100. Its epitope is not destroyed by digestion with neuraminidase i.e. its epitope id not glycosylated. Anti-PNL2 may be most useful because of its high sensitivity for metastatic melanoma (87%), as opposed to 76% for anti-HMB45 and 82% for anti-MART-1. Anti-PNL2 labels intra-epidermal nevi while the dermal component of compound nevi are largely non-reactive with anti-PNL2. Antibodies against PNL2, MART-1 (Melan A) and HMB45 stain most clear cell sarcoma cells and a few cells in angio-myolipomas and lymphangioleiomyomatosis. Anti-PNL2 is a useful antibody for the identification of melanomas and clear cell sarcomas. Differential diagnosis is aided by the results from a panel of antibodies, including antibodies against HMB45, MART-1, tyrosinase, and MiTF.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75960-616

Supplier: Biotium

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Description: CD5 Monoclonal antibody, Clone: Cris-1, Host: Mouse, Species reactivity: Human, Rhesus monkey, Isotype: IgG2a, kappa, Conjugate: CF594, Immunogen: Stimulated human leukocytes, Synonyms: CD5 antigen (p56 62), LEU1, Application: IF, IP, FC, Size: 500 uL

Catalog Number: 75914-194

Supplier: Biotium

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Description: SHBG (Sex Hormone Binding Globulin), Monoclonal antibody, Clone: SHBG/245, Host: Mouse, Species reactivity: Human, Isotype: IgG1, Conjugate: CF647, Immunogen: Recombinant full-length human SHBG protein, Application: Immunofluorescence, Immunohistology (formalin), Flow, Size: 500uL

Catalog Number: 75974-144

Supplier: Biotium

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Description: CD38 Monoclonal antibody, Clone: AT2, Host: Mouse, Species reactivity: Human, Isotype: IgM, kappa, Conjugate: BSA-free, Immunogen: human T cell line CCRF-CEM, Synonyms: Acute Lymphoblastic Leukemia Cells Antigen, Application: IF, FC, Size: 50 uL

Catalog Number: 75895-214

Supplier: Biotium

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Description: Mucin 1 / EMA / Episialin / CD227, Monoclonal antibody, Clone: VU-2G7, Host: Mouse, Species reactivity: Mouse, Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Human milk-fat globule membranes, Application: IF, Size: 100uL

Catalog Number: 75963-540

Supplier: Biotium

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Description: This antibody recognizes a protein of 205 kDa-220 kDa, identified as CD45RA (Workshop III). CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4 T-cells, 50% of peripheral CD8 T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4 or CD8 T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO ve) from B cell lymphomas (CD45RA ve).

Catalog Number: 75911-438

Supplier: Biotium

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Description: This antibody recognizes five invariable CD3 chains (designated as and ) with molecular weight ranging from 16-28 kDa. CD3 is expressed, typically at high levels, on peripheral T cells and majority of T cell neoplasms. Thymocytes express CD3 at different level on the cell surface in the course of differentiation and, in cortical thymus, CD3 is predominantly Intracytoplasmic. The CD3 complex is closely associated at the lymphocyte cell surface with T cell antigen receptor (TCR) and is involved in transducing antigen-recognition signals into cytoplasm of T cells and in regulating the cell surface expression of the TCR complex.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Catalog Number: 75895-392

Supplier: Biotium

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Description: Cytokeratin 8/18 Monoclonal antibody, Clone: B22.1 + B23.1, Host: Mouse, Species reactivity: Human, Isotype: IgG1, K, Conjugate: CF594, Immunogen: Cytoskeletal preparation from HeLa epitheliod carcinoma cells and PMC-42 breast carcinoma cells, Size: 100uL

Catalog Number: 75920-702

Supplier: Biotium

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Description: Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic Cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, Cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of Cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of Cytochrome c and to induce cell death. The release of Cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a Cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. This MAb recognizes total Cytochrome c which includes both apocytochrome (i.e. cytochrome in the cytosol without heme attached) and holocytochrome (i.e cytochrome in the mitochondria with heme attached).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75923-922

Supplier: Biotium

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Description: HIF1A, Monoclonal antibody, Clone: HIF1A-84, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: CF405S, Immunogen: Recombinant human HIF1 alpha protein, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Catalog Number: 75952-826

Supplier: Biotium

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