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Supplier: Biotium

Description: WT1 (Wilm's Tumor 1), Monoclonal antibody, Clone: 6F-H2, Host: Mouse, Species reactivity: Mouse, Rat, Human, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Recombinant protein corresponding to residues 1-181 of human WT1, Synonyms: WT1; AWT1; FWT1, Size: 100uL

Supplier: Biotium

Description: This antibody recognizes a protein of 205 kDa-220 kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4 T-cells, 50% of peripheral CD8 T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4 or CD8 T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO ve) from B cell lymphomas (CD45RA ve).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®405S is a blue fluorescent dye (Ex/Em 404/431 nm) with superior brightness compared to other blue dyes; it is also compatible with super-resolution imaging by SIM. Note: Conjugates of blue fluorescent dyes are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Supplier: Biotium

Description: MHC II Monoclonal antibody, Clone: 169-1B5.2, Host: Mouse, Species reactivity: Human, Cow, Cat, Isotype: IgG1, kappa, Conjugate: CF594, Immunogen: Human peripheral blood leukocytes, Application: Immunofluorescence, Flow cytometry, Size: 500 uL

Supplier: Biotium

Description: CD195 / CCR-5 Monoclonal antibody, Clone: 12D1, Host: Mouse, Species reactivity: Human, Isotype: IgG2a, kappa, Conjugate: CF594, Immunogen: Human native CCR5 protein, Synonyms: CC-CKR-5, CCCKR5, CCR5, Application: IF, IHC, FC, Size: 500 uL

Supplier: Biotium

Description: This MAb specifically precipitates heterogeneous material of high MW, identified as perlecan, a major heparan-sulfate proteoglycan (HSPG) within all basement membranes and cell surfaces. It does not cross-react with laminin, fibronectin, or dermatran sulfate proteoglycan. Because of perlecan s strategic location and ability to store and protect growth factors, it has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a co-receptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: This antibody recognizes actin of skeletal, cardiac, and smooth muscle cells. It is not reactive with other mesenchymal cells except for myoepithelium. Actin can be resolved on the basis of its isoelectric points into three distinctive components: alpha, beta, and gamma in order of increasing isoelectric point. Anti-muscle specific actin recognizes alpha and gamma isotypes of all muscle groups. Non-muscle cells such as vascular endothelial cells and connective tissues are non-reactive. Also, neoplastic cells of non-muscle-derived tissue such as carcinomas, melanomas, and lymphomas are negative.It stains tumors of smooth muscle (leiomyomas and leiomyosarcomas) as well as skeletal muscle (rhabdomyomas and rhabdomyosarcomas).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Supplier: Biotium

Description: Glypican-3 Monoclonal antibody, Clone: GPC3/863 + 1G12, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: Recom fragment containing amino acids 511-580, Synonyms: DGSX, GPC3, GTR2-2, Application: IF, IHC, FC, Size: 100uL

Supplier: Biotium

Description: CD71 Monoclonal antibody, Clone: DF1513, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: KG1 acute myeloid leukemia cell line, Synonyms: Mtvr-1, p90, TFR1, Application: IF, WB, FC, Size: 100uL

Supplier: Biotium

Description: Golgi Complex, Monoclonal antibody, Clone: AE-6, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: purified, Immunogen: SU-DHL-1 large cell lymphoma cells, Synonyms: Golgi Complex; Golgi apparatus; Golgi zone, Size: 100uL

Supplier: Biotium

Description: CD45RB Monoclonal antibody, Clone: PTPRC/1147, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF405S, Immunogen: Recom full-length human CD45RB protein, Synonyms: B220, CD45R, Application: IF, IHC, WB, FC, Size: 500 uL

Supplier: Biotium

Description: SUMO-1, Monoclonal antibody, Clone: SUMO1/1188, Host: Mouse, Species reactivity: Human, Rat, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Recombinant human SUMO1 protein, Application: Immunofluorescence, Immunohistology (formalin), Western, Flow cytometry, Size: 500uL

Supplier: Biotium

Description: Calponin-1 Monoclonal antibody, Clone: CALP, Host: Mouse, Species Reactivity: Human, Rat, Isotype: IgG's, Conjugate: CF405S, Immunogen: Multiple isoelectric variants of calponin, 34kDa/29kDa, Synonyms: Calponin H1 smooth muscle, Application: IF, Immunohistology, Fc, Size: 500ul

Supplier: Biotium

Description: This antibody recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: (75911-228)

Supplier: Biotium

Description: This antibody recognizes a cell surface glycoprotein of 80-95 kDa (CD44) on lymphocytes, monocytes, and granulocytes (Leucocyte Typing Workshop V). Its epitope is resistant to digestion by trypsin and chymotrypsin. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95 kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44 immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium.

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Supplier: Biotium

Description: Ep-CAM / CD326 Monoclonal antibody, Clone: VU-1D9, Host: Mouse, Conjugate: CF405S, Species reactivity: Human, Immunogen: Small cell lung carcinoma cells, Isotype: IgG1, kappa, Application: IF, FC, IHC, WB, Size: 500 uL