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Supplier: Biotium

Description: Myogenin, Monoclonal antibody, Clone: F5D, Host: Mouse, Species reactivity: Pig, Dog, Cat, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF488A, Immunogen: Rat myogenin peptide (aa 73-94), recombinant fragment (aa30-224), Synonym:cb553, Size: 100uL

Supplier: Biotium

Description: The epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2 levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH); also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.

Supplier: Biotium

Description: FOXP3 Monoclonal antibody, Clone: 3G3, Host: Mouse, Species reactivity: Mouse, Monkey, Human, Isotype: IgG1, kappa, Conjugate: CF555, Immunogen: Full-length His-tagged mouse FOXP3 protein, Application: Immunofluorescence, Flow cytometry, Size: 100uL

Supplier: Biotium

Description: HIF1A, Monoclonal antibody, Clone: HIF1A-84, Host: Mouse, Species reactivity: Human, Isotype: IgG2b, kappa, Conjugate: biotin, Immunogen: Recombinant human HIF1 alpha protein, Application: Immunofluorescence, Flow cytometry, Size: 500uL

Supplier: Biotium

Description: Bax Monoclonal antibody, Clone: 2D2, Host: Mouse, Species reactivity: Human, Monkey, Isotype: IgG1, Conjugate: purified, Immunogen: A synthetic peptide, aa 3-16 (Cys-GSGEQPRGGGPTSS) of human bax protein, Application: IF, Immunohistology, Western, FC, Size: 500 uL

Supplier: Biotium

Description: CD43Monoclonal antibody, Clone: SPN/1094, Host: Mouse, Conjugate: CF405S, Species reactivity: Human, Isotype: IgG1, kappa, Immunogen: Recom human SPN protein, Synonyms: GALGP, GPL115, Application: IF, IHC, FC, Size: 500 uL

Supplier: Biotium

Description: This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

Supplier: Biotium

Description: CF® Dyes with a BCN group react with azides via a copper-free bioorthogonal reaction to label target molecules for surface staining of live cells or cell extracts. Membrane-permeant CF® Dye BCN conjugates for intracellular labeling reactions are also available.

Supplier: Biotium

Description: Cytokeratin 7 is a basic cytokeratin, which is found in most glandular and transitional epithelia but not in the stratified squamous epithelia. Keratin 7 is expressed in the epithelial cells of ovary, lung, and breast but not of colon, prostate, or gastrointestinal tract. Antibody to cytokeratin is useful in distinguishing ovarian carcinomas (keratin 7 ) from colon carcinomas (keratin 7-).

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Supplier: Biotium

Description: CD74 Monoclonal antibody, Clone: BU45, Host: Mouse, Species reactivity: Human, Isotype: IgG1, kappa, Conjugate: CF647, Immunogen: B lymphoblastoid cell line HFB1Unigene 436568, Application: Immunofluorescence, Western, Flow cytometry, Size: 500 uL

Supplier: Biotium

Description: CD28 Monoclonal antibody, Clone: C28/77, Host: Mouse, Conjugate: CF647, Species reactivity: Human, Immunogen: Recombinant human CD28 protein, Isotype: IgG1, kappa, Synonyms:T-cell-specific surface glycoprotein CD28, Application: IF, IHC (formalin), FC, Size: 500 uL

Supplier: Biotium

Description: Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of α, β, and γ chains. This MAb reacts with laminin B2/1 chain of ~210 kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Supplier: Biotium

Description: This antibody recognizes a single protein of 33-34 kDa, identified as the prostate specific antigen (PSA). This MAb is highly specific to PSA and stains prostatic secretory and ductal epithelium in both normal and neoplastic tissues. PSA is a chymotrypsin-like serine protease (kallikrein family) exclusively produced by the prostate epithelium, and abundant in seminal fluid. PSA can be detected in the sera of patients with prostatic carcinoma. It is predominantly complexed to a liver-derived serine protease inhibitor, alpha-1-antichymotrypsin (ACT). A higher proportion of serum PSA is complexed to ACT in prostate cancer than in benign prostate hyperplasia.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®647 is a far-red fluorescent dye (Ex/Em 650/665 nm) with excellent brightness. It also is compatible with super-resolution imaging by STORM.

Supplier: Biotium

Description: This antibody is specific to Insulin-like Growth Factor (IGF-1) and shows minimal cross-reaction with IGF-11, Proinsulin, MSF, and Insulin. IGF-1 is a polypeptide growth factor with two isoforms that are produced by alternative splicing. Isoform 1 is also known as IGF-IB while isoform 2 is known as IGF-IA. IGF-1 stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It functions as an autocrine regulator of growth. Activation of IGF system has emerged as a key factor for tumor progression and resistance to apoptosis in many cancers like those of breast, thyroid and colon.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®594 is a deep red fluorescent dye (Ex/Em 593/614 nm). It yields the brightest conjugates among spectrally similar dyes, and has excellent photostability.

Supplier: Biotium

Description: Cytokeratin 18 Monoclonal antibody, Clone: KRT18/834, Host: Mouse, Species reactivity: Human, Isotype: IgG's, Conjugate: CF568, Immunogen: Recom full-length human KRT18 protein, Synonyms: K18, Application: IF, IHC, FC, Size: 500 uL

Supplier: Biotium

Description: S100, Monoclonal antibody, Clone: 4C4.9 + S100A1/1012, Host: Mouse, Species reactivity: Mouse, Cow, Rat, Human, Isotype: IgG2a, kappa, Conjugate: CF640R, Immunogen: Purified bovine brain S100 protein, Synonyms: Bpb; NEF; S100-A1; S100 Alpha Chain, Application: IF, Size: 500uL