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Description: This antibody recognizes a protein of 205 kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75883-402

Supplier: Biotium

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Description: This MAb recognizes a single chain, transmembrane, heavily glycosylated protein of 90-120 kDa, which is identified as CD34. Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, CD34 is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. Its expression is also found in vascular endothelium. Additionally, it appears that proliferating endothelial cells express this molecule more than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi's sarcoma, but with a lower specificity.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75894-684

Supplier: Biotium

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Description: This MAb is specific to progesterone receptor and shows minimal cross-reaction with other members of the family. Progesterone receptor is expressed as two major isoforms, PR-A (81 kDa) and PR-B (116 kDa). Expression of PgR has been suggested to reflect a intact estrogen regulatory machinery and therefore, predict better clinical response to endocrine therapy than ER alone.

Catalog Number: 75971-732

Supplier: Biotium

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Description: This MAb reacts with an extracellular domain (close to transmembrane) of CD56/NCAM. Three isoforms of neural cell adhesion molecule (NCAM) are produced by differential splicing of the RNA transcript from a single gene. The 135 kDa isoform is the basic molecule, which is glycosylated or sialylated to produce the mature species. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®568 is a red fluorescent dye (Ex/Em 562/583 nm) with superior brightness and photostability. It also is compatible with super-resolution imaging by STORM and TIRF.

Catalog Number: 75912-416

Supplier: Biotium

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Description: This MAb reacts with MUC1. The dominant epitope of this MAb has not yet been determined. MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and over expressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four c-erbB receptors and localize with c-erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells. Antibody to EMA is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.

Catalog Number: 75963-918

Supplier: Biotium

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Description: DPX is a positively charged quencher that is often used with ANTS (90010) to study membrane fusion or permeability.

Catalog Number: 89139-476

Supplier: Biotium

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Description: Anti-IgG Goat Polyclonal Antibody (CF™ 640R)

Catalog Number: 89493-426

Supplier: Biotium

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Description: Min X Bv Ch Gt Hs Hu Ms Rb Sh SHm. CF405S is a blue fluorescent dye with good spectral compatibility with popular instruments.

Catalog Number: 89411-546

Supplier: Biotium

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Description: Anti-IgG Donkey Polyclonal Antibody (CF™ 660R)

Catalog Number: 89493-550

Supplier: Biotium

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Description: Antibody Conjugates Prepared From Near-Infrared Cf790 Dye Are Brighter And Have By Far The Best Signal-To-Noise Ratio Compared To Spectrally Similar Dyes; Antibody Has Minimal Cross-Reactivity With Chicken, Guinea Pig, Syrian Hamster, Horse, Human.

Catalog Number: 89427-204

Supplier: Biotium

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Description: Progesterone, Monoclonal antibody, Clone: 6-5E-10B, Host: Mouse, Species reactivity: All species, Isotype: IgG1, kappa, Conjugate: biotin, Immunogen: Progesterone hemisuccinate conjugated to bsa, Synonyms: Pregn 4 ene 3 20 dione; Pregn 4 ene 3 20 dione, Size: 500uL

Catalog Number: 75971-468

Supplier: Biotium

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Description: The Antibody Reacts With Igm Heavy Chains (Mu Chains) And Not With Immunoglobulin Light Chains 2 Mg/Ml In Ph Approximately7.4 Pbs, 50% Glycerol, 2 Mg/Ml Bovine Serum Albumin (Igg-Free And Protease-Free).

Catalog Number: 89493-528

Supplier: Biotium

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Description: CD31 / PECAM-1 Monoclonal antibody, Clone: JC/70A, Host: Mouse, Species reactivity: Rabbit, Cynomolgus monkey, Human, Isotype: IgG1, kappa, Conjugate: CF568, Immunogen: Membrane preparation, Synonyms: EndoCAM, PECA1, Application: IF, IHC, FC, Size: 500uL

Catalog Number: 75892-830

Supplier: Biotium

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Description: This antibody recognizes a protein of 30-33 kDa, which is identified as CD20 (Workshop V; Code CD20.4). It is a non-Ig differentiation antigen of B-cells and its expression is restricted to normal and neoplastic B-cells, being absent from all other leukocytes and tissues. CD20 is expressed by pre B-cells and persists during all stages of B-cell maturation but is lost upon terminal differentiation into plasma cells. The protein passes through the membrane 4 times with both ends in cytoplasm and exposes one short and one longer loop to the external environment. CD20 is not glycosylated in resting B-cells and its cytoplasmic domains are differentially phosphorylated upon activation. It acts as calcium channel involved in B cell activation and cell cycle progression.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®640R is a far-red fluorescent dye (Ex/Em 642/662 nm) with excellent brightness, and the best photostabiity among spectrally-similar dyes.

Catalog Number: 75890-582

Supplier: Biotium

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Description: Ep-CAM / CD326 Monoclonal antibody, Clone: VU-1D9, Host: Mouse, Conjugate: CF640R, Species reactivity: Human, Immunogen: Small cell lung carcinoma cells, Isotype: IgG1, kappa, Application: IF, FC, IHC, WB, Size: 100uL

Catalog Number: 75893-988

Supplier: Biotium

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Description: CD2 interacts through its amino-terminal domain with the extracellular domain of CD58 (also designated CD2 ligand) to mediate cell adhesion. CD2/CD58 binding can enhance antigen-specific T cell activation. CD2 is a transmembrane glycoprotein that is expressed on peripheral blood T lymphocytes, NK cells and thymocytes. CD58 is a heavily glycosylated protein with a broad tissue distribution in hematopoietic and other cells, including endothelium. Interaction between CD2 and its counter receptor LFA3 (CD58) on opposing cells optimizes immune system recognition, thereby facilitating communication between helper T lymphocytes and antigen-presenting cells, as well as between cytolytic effectors and target cells.

CF® dyes are Biotium's next-generation fluorescent dyes. CF®488A is a green fluorescent dye (Ex/Em 490/515 nm) with excellent brightness and photostability. The dye is minimally charged for less non-specific binding. CF®488A also is compatible with super-resolution imaging by TIRF.

Catalog Number: 75890-150

Supplier: Biotium

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