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Supplier: Enzo Life Sciences
Description: Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.

Catalog Number: (76003-428)
Supplier: Enzo Life Sciences
Description: Produced in HEK 293 cells.


Catalog Number: (76199-136)
Supplier: Enzo Life Sciences
Description: For the quantitative determination of IL-1β in culture supernatants and serum of rat origin.


Catalog Number: (76002-320)
Supplier: Enzo Life Sciences
Description: Recommended Applications: Flow Cytometry

Species reactivity: Human


Catalog Number: (89162-834)
Supplier: Enzo Life Sciences
Description: Host: Mouse, Isotype: IgG2b


Catalog Number: (101410-452)
Supplier: Enzo Life Sciences
Description: The Insulin Receptor (InsR) is a heterodimeric receptor tyrosine kinase with an extracellular alpha-chain, a transmembrane domain and an intracellular beta-chain. InsR is activated upon binding of the peptide hormone insulin, leading to autophosphorylation of tyrosine residues 1146, 1150, and 1151 in the activation loop of the beta-chain. Additional autophosphorylation sites such as tyrosine residues 960, 972, 1316, and 1322 regulate the assembly of signal transduction complexes.


Catalog Number: (89164-000)
Supplier: Enzo Life Sciences
Description: Produced in E. coli.


Supplier: Enzo Life Sciences
Description: The 90 kDa molecular chaperone family includes 90 kDa heat shock protein Hsp90 and 94 kDa glucose-regulated protein grp94, both major molecular chaperones of the cytosol and the endoplasmic reticulum. Mammalian cells express inducible Hsp90 alpha and constitutive Hsp90 beta isoforms that are encoded by separate genes. The amino acid sequences of human and yeast Hsp90 alpha are 85% and 90% homologous to those of Hsp90 beta, respectively. All known members of the Hsp90 protein family are highly conserved, especially in the N-terminal and C-terminal regions containing independent chaperone sites with different substrate specificity. These ubiquitous and highly conserved proteins account for 1-2% of all cellular protein in most cells. Hsp90 functions as part of the cell's powerful network of chaperones to fight the deleterious consequences of protein unfolding caused by non-physiological conditions. In the absence of stress, however, Hsp90 provides a necessary component of such fundamental cellular processes as hormone signaling and cell cycle control by serving as a chaperone for many key signaling molecules including steroid receptors, cell cycle kinases involved in signal transduction, and p53. As many of these client proteins are known oncogenes, Hsp90 inhibitors such as 17-AAG, a geldanamycin analog, have been of benefit in the treatment of many cancers.

Supplier: Enzo Life Sciences
Description: Produced in E. coli.

Catalog Number: (76284-944)
Supplier: Enzo Life Sciences
Description: Recombinant monclonal antibody (Rabbit IgGκ).


Catalog Number: (76284-942)
Supplier: Enzo Life Sciences
Description: Recombinant monclonal antibody (Mouse IgG1κ).


Supplier: Enzo Life Sciences
Description: Key inhibitor for use in proteasome research.

Catalog Number: (76201-934)
Supplier: Enzo Life Sciences
Description: Recombinant monoclonal antibody


Catalog Number: (76002-566)
Supplier: Enzo Life Sciences
Description: Recommended Applications: IHC (PS), WB

Species reactivity: Human, Mouse


Catalog Number: (89163-310)
Supplier: Enzo Life Sciences
Description: Host: Rabbit


Supplier: Enzo Life Sciences
Description: A highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM).

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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