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Supplier: Enzo Life Sciences
Description: Alpha-crystallins composed of alpha A (~20 kDa) and alpha B (~20 kDa) subunits, are major water-soluble proteins accounting for almost 50% of total protein in the mammalian transparent eye lens and they are also found in a variety of other tissues. The two other crystallin families, beta and gamma, are homologous to each other but not to the alpha family or the sHsp's. Alpha-crystallins are also referred to as small heat shock proteins, since they are induced by increased temperature in a variety of organisms. The alpha-crystallins have sequence homology as well as structural and functional similarities with the small Hsp's such as Hsp25/27. Most small heat shock proteins have four common structural and functional features: (i) molecular weight between 12 and 43kDa; (ii) the formation of large oligomeric complexes composed of alphaA-crystallin, alphaB-crystallin and Hsp25/27; (iii) the moderately conserved alpha-crystallin domain in the central region of the protein; and (iv) molecular chaperone activity. The alpha-crystallin domain comprises approximately 90 residues, is bounded by variable N-terminal and C-terminal extensions and is involved in oligomer assembly. Oligomers can reach 800kDa or more and are dynamic, exhibiting subunit exchanges and organizational plasticity, possibly leading to functional diversity. Phosphorylation of serine residues occurs during development and in response to stress, and usually decreases oligomer size. Chaperone activity requires, and is modulated by, oligomerization and is limited to binding unfolded intermediates to prevent irreversible aggregation, although productive release and refolding of denatured proteins requires close cooperation with other chaperones. Other proposed functions include a role in membrane stabilization and modulation of intermediate filament organization during physiological stress and neurodegenerative disease.

Catalog Number: (89150-920)
Supplier: Enzo Life Sciences
Description: Potentiates PKC activity


Catalog Number: (76284-842)
Supplier: Enzo Life Sciences
Description: Recombinant monclonal antibody (Rat IgG2cκ).

Recommended Applications: Flow Cytometry, WB


Catalog Number: (89157-886)
Supplier: Enzo Life Sciences
Description: Inhibits cytochrome P-450-mediated prostaglandin ω/ω-1 hydroxylase activity.


Catalog Number: (10049-898)
Supplier: Enzo Life Sciences
Description: LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis. LTβR is a type I transmembrane glycoprotein and member of the TNF receptor superfamily. It is a 61kDa receptor for the mouse LTα1β2 and LIGHT. Northern blot analysis of tissues from adult mice showed that expression levels of LTβR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. It was reported that LTβR is expressed on stromal cells, monocytes, and certain embryonic epithelial layers. LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis.


Catalog Number: (89145-226)
Supplier: Enzo Life Sciences
Description: Host: Rabbit


Catalog Number: (89161-122)
Supplier: Enzo Life Sciences
Description: Reduces food intake


Catalog Number: (76002-670)
Supplier: Enzo Life Sciences
Description: Recommended Applications: Flow Cytometry, IF

Species reactivity: Human


Catalog Number: (89150-426)
Supplier: Enzo Life Sciences
Description: Antibiotic


Supplier: Enzo Life Sciences

Supplier: Enzo Life Sciences
Description: Lysosome-associated membrane proteins (LAMP1 and LAMP2) are type I integral membrane protein that are transported from the trans-Golgi network to endosomes and then lysosomes. Following activation of platelets, T-cells, neutrophils, or endothelium, LAMP1 and LAMP2 are expressed on the cell surface. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and loss of LAMP2 expression is associated with impaired autophagy observed in Danons disease.

Catalog Number: (10033-644)
Supplier: Enzo Life Sciences
Description: Produced in baculovirus system


Catalog Number: (89152-902)
Supplier: Enzo Life Sciences
Description: Fluorescent probe for NO detection.


Catalog Number: (89147-736)
Supplier: Enzo Life Sciences
Description: Highly selective and potent inhibitor of cyclooxygenase-2 (IC50=10nM for COX-2 versus IC50=17.8µM for COX-1) with antitumor properties. Exhibits longer half-life time and reduced gastric toxicity in fasting rat model. Has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. Potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.


Catalog Number: (76418-086)
Supplier: Enzo Life Sciences
Description: Produced in <i>E. coli</i>. Coronavirus (SARS-CoV) nucleoprotein (422 aa) is fused to a His-tag.


Catalog Number: (89160-536)
Supplier: Enzo Life Sciences
Description: L-NASPA is an antagonist of LPA-induced platelet aggregation and chloride conductance in Xenopus oocytes. In human breast carcinoma MDA-MB231 cells it is a potent LPA agonist.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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