5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione ≥95% (by HPLC)

Supplier: Van Der Voort Lucht en Milieu Amste

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CDX-P0110-M005 CDX-P0110-M010 CDX-P0110-M050

102990-834EA 131.54 USD

102990-834 102990-836 102990-838

5-[(4-Propyloxyphenyl)methylene] 2,4-thiazolidinedione ≥95% (by HPLC)

5-[(4-Propyloxyphenyl)methylene]-2,4-thiazolidinedione (SMI-16a)

Potent, cell-permeable, ATP-competitive inhibitor of Pim-1/2 kinases (IC50 = 150 nM and 20 nM against Pim-1 and Pim-2, respectively) as well as DYRK1alpha (68% inhibition of DYRK1alpha and Pim-2 at 5 µM), while exhibiting little or no activity against a panel of 57 other kinases (18% inhibition at 5 µM). Reported to exhibit antitumor activity in PC3 human prostate cancer cultures in vitro (IC50 = 48 µM) and in JC adenocarcinoma-transplanted Balb/C mice in vivo (~46% tumor mass reduction on day 20| 50 mg/kg via daily i.p.).

Formula: C₁₃H₁₃NO₃S
Storage Temperature: Freezer

MDL Number: MFCD31382191
CAS Number: 587852-28-6

Specification Test Results

Source/Host	Synthetic
Purity	95% (HPLC)
Appearance/Color	Yellow powder.
Solubility	Soluble in DMSO.

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