You Searched For: Van Der Voort Lucht en Milieu Amste

Catalog Number: (102989-766)

Supplier: Adipogen

Description: A puromycin analog that acts as a protein kinase inhibitor. Selectively induces premature mitosis in mammalian cells. Inhibits TNF-alpha upregulation of ICAM-1, lipolysis, and the activation of JNK/SAPK. Inhibits p34cdc2/cyclin B (IC50 = 300 µM). Induces apoptosis in S-phase-arrested HeLa cells (~5 mM).

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Supplier: Adipogen

Description: Triphenyl tetrazolium chloride, TTC, or simply tetrazolium chloride is a redox indicator commonly used in biochemical experiments especially to indicate cellular respiration.

Supplier: Adipogen

Description: Sulfamethoxazole hydroxylamine is a metabolite of sulfamethoxazole, a sulfonamide bacteriostatic antibiotic.

Supplier: Adipogen

Description: One of the principal active constituents of St. John's Wort (Hypericum perforatum). Hypericin is a photosensitive pigment/chromophore with bright red fluorescence emission (lambdamax: 594nm). Has a high triplet quantum yield and ability to produce considerable amounts of singlet oxygen and other ROS species when photoactivated. Antiviral, anticancer and antidepressant agent. Inactivates enveloped viruses (including HIV). This photosensitizing agent has shown to induce apoptosis and necrosis in cancer cells during photodynamic therapy. Selective inhibitor of protein kinase C (PKC). Has been shown to inhibit other kinases and targets such as EGFR-PTK, PI3K, CKII, MAPK and insulin receptor (IR). Necrosis-avid contrast agent investigated for use in non-invasively targeting necrotic tissues, based on to be defined components in the phospholipid bilayer.

Supplier: Adipogen

Description: Shows strong gastrointestinal motor stimulating (GMS) activity. Motilin receptor agonist. Stimulates smooth muscle cell contraction. Stimulates cholinergic neurons in a non-vagal pathway. Enhances gastrointestinal contractile activity and accelerates gastric emptying. Shows orexigenic activity with affinity for the growth-hormone secretagogue receptor (GHS-R, ghrelin receptor).

Catalog Number: (102512-052)

Supplier: Adipogen

Description: Human CD14 is strongly expressed on myelomonocyte lineage cells including monocytes, macrophages and a subset of granulocytes. CD14 is a high affinity receptor for complexes of lipopolysaccharide and lipopolysaccharide binding protein. A soluble form of CD14 also binds to LPS and LBP.

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Catalog Number: (102513-332)

Supplier: Adipogen

Description: Human CD270 (Herpes Virus Entry Mediator; TNFRSF14; ATAR; LIGHTR; TR2) is a 36kDa type I membrane protein that has been found on a broad range of lymphoid tissues. Its ligands include the TNF ligand family members LTalpha and LIGHT and the CD28/Ig superfamily member BTLA.

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Supplier: Adipogen

Description: Phosphoinositide-dependent kinase 1 (PDK1) inhibitor. Potent, reversible and ATP-competitive glycogen synthase kinase-3alpha/beta (GSK-3alpha/beta) inhibitor. JAK/STAT3 signaling inhibitor. Apoptosis inducer. Potent antiproliferative agent in malignant lymphoid cell. Antimetastatic agent. Potent chemosensitizing agent fighting TRAIL resistant cancer cells.

Catalog Number: (102512-134)

Supplier: Adipogen

Description: Human CD22 expression is restricted to normal Ig+ mature B cells and neoplastic B cells. CD22 is a transmembrane glycoprotein of 140kDa with a predicted adhesion molecule function.

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Supplier: Adipogen

Description: TNF-R1 is a receptor for TNF-alpha and homotrimeric lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.

Catalog Number: (102512-644)

Supplier: Adipogen

Description: Human DR3 (TRAMP; LARD) was designated TNF receptor superfamily member 25. TL1A is a ligand which can induce apoptosis through a cytoplasmic death domain similar to the CD178-CD95 (FasL-Fas) interaction. Alternatively, engagement of DR3 on T cells can synergize with other activating signals to enhance IFNgamma production.

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Catalog Number: (102515-676)

Supplier: Adipogen

Description: Lck (p56lck; lymphocyte specific tyrosine kinase) inhibitor. Antioxidant. DPPH radical scavenger.

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Supplier: Adipogen

Description: N-Dodecanoyl-L-homoserine lactone (C12-HSL) is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta (IL-1beta) and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte (HaCaT) cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-homoserine lactone, which is produced at different times in biofilm development and has different cellular effects.

Catalog Number: (102514-576)

Supplier: Adipogen

Description: FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse 'fused toes' mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

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Supplier: Adipogen

Description: Building block for synthesis.

Supplier: Adipogen

Description: Polarity fluorescent probe.