Phorbol 12-myristate 13-acetate ≥98% (by HPLC)

Supplier: Van Der Voort Lucht en Milieu Amste

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AG-CN2-0010-M001 AG-CN2-0010-M005 AG-CN2-0010-M010 AG-CN2-0010-M025

102515-692EA 52.62 USD

102515-692 102515-694 102515-696 102515-698

Phorbol 12-myristate 13-acetate ≥98% (by HPLC)

Phorbol-12-myristate-13-acetate

Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin.

Formula: C₃₆H₅₆O₈
Storage Temperature: Freezer

MDL Number: MFCD00036736
CAS Number: 16561-29-8

Specification Test Results

Source/Host	Semisynthetic.
Purity	98% (HPLC)
Appearance/Color	White to off-white solid.
Solubility	Soluble in DMSO, methanol, 100% ethanol, acetone, ether or dimethylformamide; almost insoluble in aqueous buffers.

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