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You Searched For: Phorbol-12-myristate-13-acetate


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Phorbol-12-myristate-13-acetate ≥99%, colorless material

Supplier: MP Biomedicals
Description: PMA (Phorbol-12-Myristate-13-Acetate) is a diester of phorbol and is a tumor promoting compound extracted from croton oil. It is a reversible, highly potent protein kinase C (PKC) activator in vitro and in vivo at nM concentrations. PMA’s effects on PKC are attributed to its similarity to diacylgylerol, a natural activator of PKC.
PMA activates Ca2+- ATPase and potentiates forskolin-induced cAMP formation. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells.
Potent tumor promoter; activates protein kinase C in vivo and in vitro.
Store at -20 °C. Protect from light.

Product Image-76203-482

Phorbol-12-myristate-13-acetate ≥99% (by TLC)

Catalog Number: (76203-482)
Supplier: Enzo Life Sciences
Description: PKC activator
Product Image-TS35615-0010

Phorbol-12-myristate-13-acetate 97%

Supplier: THERMO FISHER SCIENTIFIC CHEMICALS
Description: Phorbol-12-myristate-13-acetate 97%

Image Unavailable-80055-400

Phorbol-12-myristate-13-acetate, Sigma-Aldrich®

Supplier: MilliporeSigma
Description: Most commonly-used phorbol ester

Certificates

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Phorbol-12-myristate-13-acetate 95%

Supplier: AMBEED, INC
Description: Phorbol-12-myristate-13-acetate 95%

New Product

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Phorbol-12-myristate-13-acetate 95%

Supplier: Thermo Scientific Chemicals
Description: Activates protein kinase C and promotes skin tumors in mice.

SDS Certificates

Image Unavailable-102515-692

Phorbol 12-myristate 13-acetate ≥98% (by HPLC)

Supplier: Adipogen
Description: Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin.

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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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