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Supplier: PeproTech, Inc.

Description: Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in host response to invading bacterial, viral, parasite and fungal pathogens, by regulating the trafficking, and activation state, of selected subgroups of inflammatory cells (e.g. macrophages, lymphocytes and NK cells). While both MIP-1α and MIP-1β exert similar effects on monocytes, their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes, and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant Rat MIP-1α (CCL3) is a 7.8 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Catalog Number: (10774-838)

Supplier: PeproTech, Inc.

Description: Monoclonal AntibodyProduced in BALB/c x C57BL/6 F1-mice immunized with highly pure Recombinant Human IL-6. Anti­Human IL-6­specific antibody was purified from ascites fluid by Protein A affinity chromatography.

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Supplier: PeproTech, Inc.

Description: IFN λ1, 2, and 3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and interferons. All three IFN-lambdas use a distinct receptor system composed of an IFN- λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defenses similar to, but distinct from, that of type I interferons. Recombinant Murine IFN- λ2 is a 19.8 kDa protein containing 175 amino acid residues.

Catalog Number: (10774-874)

Supplier: PeproTech, Inc.

Description: Monoclonal AntibodyProduced in BALB/c x ICR F1-mice immunized with highly pure Recombinant Human MIG (CXCL9). Anti­Human MIG (CXCL9)­specific antibody was purified from ascites fluid by Protein A affinity chromatography.

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Catalog Number: (10771-534)

Supplier: PeproTech, Inc.

Description: PeproTech's Rat IL-6 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant rat IL-6 in a sandwich ELISA format.

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Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Murine IL-1α. Anti­Murine IL-1α­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10774-880)

Supplier: PeproTech, Inc.

Description: Monoclonal AntibodyProduced in BALB/c x ICR F1-mice immunized with highly pure Recombinant Human sRANK Ligand. Anti­Human sRANK Ligand­specific antibody was purified from cell culture by Protein G affinity chromatography.

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Supplier: PeproTech, Inc.

Description: Angiopoietin-1 (ANG-1) is a secreted ligand for Tie-2, a tyrosine-kinase receptor expressed primarily on vascular endothelial cells and early hematopoietic cells. ANG-1/Tie-2 signaling promotes angiogenesis during the development, remodeling, and repair of the vascular system. Transgenic mice lacking expression of either ANG-1 or Tie-2 fail to develop a fully functional cardiovascular system and die before birth. Postnatally, the angiogenic activity of ANG-1/Tie-2 is required during normal tissue repair and remodeling of the female endometrium in the menstrual cycle. ANG-1/Tie-2 signaling appears to be regulated by Angiopoietin-2 (ANG-2), a natural antagonist for Tie-2 that exerts its effects through an internal autocrine loop mechanism. In addition to suppressing endothelial cell activation by inhibiting the expression of adhesion and inflammatory molecules, Ang-1 enhances endothelial cell survival and capillary morphogenesis, and lessens capillary permeability. As such, ANG-1 has potential to become an effective therapeutic agent for treating various endothelium disorders, including several severe human pulmonary diseases. The efficacy of cell-based Ang-1 gene therapy for acute lung injury (ALI) has recently been studied in a rat model of ALI. The results of this study show that such therapy can markedly improve lung condition and suggest that Ang-1 therapy may represent a potential new strategy for the treatment and/or prevention of acute respiratory distress injury (ARDI), a significant cause of morbidity and mortality in critically ill patients. Recombinant Human ANG-1, derived from

Catalog Number: (76303-664)

Supplier: PeproTech, Inc.

Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Murine VEGF 165 is a 39.0 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.

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Catalog Number: (10777-634)

Supplier: PeproTech, Inc.

Description: PeproTech's Human FGF-basic ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human FGF-basic in a sandwich ELISA format.

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Supplier: PeproTech, Inc.

Description: Produced from sera of rabbits immunized with highly pure Recombinant Human MIP-1β (CCL4). Anti­Human MIP-1β (CCL4)­specific antibody was purified by affinity chromatography employing an immobilized Human MIP-1β matrix.

Catalog Number: (76303-588)

Supplier: PeproTech, Inc.

Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. VEGF signals through three receptors; fms-like tyrosine kinase (flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Due to its increased acidity, VEGF 121 circulates more freely than other VEGF forms, which bind more tightly with vascular heparin sulfates. Recombinant Human VEGF 121 is a 28.4 kDa, disulfide-linked homodimeric protein consisting of two 121 amino acid polypeptide chains.

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Catalog Number: (10774-902)

Supplier: PeproTech, Inc.

Description: Monoclonal AntibodyProduced in C3H/HeJ-mice immunized with highly pure Recombinant Human MIP-1α (CCL3). Anti­Human MIP-1α (CCL3)­specific antibody was purified from ascites fluid by SAS precipitation followed by ion exchange chromatography.

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Catalog Number: (76303-796)

Supplier: PeproTech, Inc.

Description: Human IL-31 is a T cell-derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (also known as gp130-like receptor or IL-31RA) and Oncostatin-M receptor (OSMR). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, JAK1, and JAK2 signaling pathways. IL-31-regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant Human IL-31 is a 15.8 kDa protein containing 141 amino acid residues.

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Catalog Number: (10771-886)

Supplier: PeproTech, Inc.

Description: The IGFs are mitogenic, polypeptide growth factors that stimulate the proliferation and survival of various cell types, including muscle, bone, and cartilage tissue in vitro . IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar to insulin by structure and function, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor (IGF-IR), but IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds. IGF-I LR3 is a recombinant analog of human IGF-I comprised of the complete IGF-I sequence, with an Arginine substitution for the third position Glutamic acid, and a 13 amino acid length N terminus peptide extension. Specifically engineered for higher biological potency Recombinant Human IGF-I LR3 is a 9.1 kDa, single, non-glycosylated polypeptide chain containing 83 amino acid residues.

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Catalog Number: (10771-542)

Supplier: PeproTech, Inc.

Description: PeproTech's Human SDF-1α (CXCL12) ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant Human SDF-1α (CXCL12) in a sandwich ELISA format.

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