Human Recombinant sTNF (from E. coli)

Supplier: PEPROTECH INC.
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310-07-5UG 310-07-20UG 310-07-50UG 310-07-100UG 310-07-250UG 310-07-500UG 310-07-1MG
10770-818EA 132.81 USD
10770-818 10770-820 10770-822 10770-824 10770-826 10770-828 10770-830
Human Recombinant sTNF (from E. coli)
Proteins and Peptides

TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein.


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