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Catalog Number: (76303-590)
Supplier: PeproTech, Inc.
Description: The three mammalian isoforms of TGF-beta, TGF-beta1, beta2, and beta3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-beta isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. The physiological role of TGF-beta3 is still unknown, but its expression pattern suggests a role in the regulation of certain development processes. Recombinant Human TGF-beta3 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.


Catalog Number: (10771-668)
Supplier: PeproTech, Inc.
Description: PeproTech's Human SCF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human SCF in a sandwich ELISA format.


Catalog Number: (76303-878)
Supplier: PeproTech, Inc.
Description: VEGF is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothellial cells, and promotes angiogenesis and vascular permeability. Expressed in vascularized tissues, VEGF plays a prominent role in normal and pathological angiogenesis. Substantial evidence implicates VEGF in the induction of tumor metastasis and intra-ocular neovascular syndromes. VEGF signals through the three receptors; fms-like tyrosine kinase(flt-1), KDR gene product (the murine homolog of KDR is the flk-1 gene product) and the flt4 gene product. Recombinant Rat VEGF 165 is a 38.5 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains.


Catalog Number: (10771-590)
Supplier: PeproTech, Inc.
Description: PeproTech's Murine IGF-I ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine IGF-I in a sandwich ELISA format.


Catalog Number: (10777-706)
Supplier: PeproTech, Inc.
Description: PeproTech's Rat CNTF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant Rat CNTF in a sandwich ELISA format.


Catalog Number: (10771-684)
Supplier: PeproTech, Inc.
Description: PeproTech's Murine IL-2 ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine IL-2 in a sandwich ELISA format.


Supplier: PeproTech, Inc.
Description: Produced from sera of rabbits immunized with highly pure Recombinant Rat IL-10. Anti­Rat IL-10­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10771-652)
Supplier: PeproTech, Inc.
Description: PeproTech's Human VEGF ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant human VEGF in a sandwich ELISA format.


Supplier: PeproTech, Inc.
Description: The dickkopf (DKK)-related protein family is comprised of four central members, DKK-1 - 4, along with the distantly-related DKK family member DKK-L1 (Soggy), which is thought to be a descendent of an ancestral DKK-3 precursor due to its unique sequence homology to DKK-3 and no other DKK family member. DKK family members, with the exception of the divergent Soggy, share two conserved cysteine-rich domains and show very little sequence similarity outside of these domains. Playing an important regulatory role in vertebrate development through localized inhibition of Wnt-regulated processes, including anterior-posterior axial patterning, limb development, somitogenesis, and eye formation, DKKs have also been implicated post-developmentally in bone formation, bone disease, cancer, and neurodegenerative diseases. DKK proteins typically play an important regulatory role in the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LDL receptor-related proteins 5 and 6 (LRP5 and LRP6), which are essential components of the Wnt/β-catenin signaling system. LRP5 and LRP6 are single-pass transmembrane proteins that appear to act as co-receptors for Wnt ligands involved in the Wnt/β-catenin signaling cascade. DKK-3 has been shown to potentiate, rather than inhibit, Wnt signaling through interactions with the high-affinity, transmembrane co-receptors Kremen-1 (Krm1) and Kremen-2 (Krm2). Recombinant Human DKK-3 expressed in

Supplier: PeproTech, Inc.
Description: Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand exerts no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant Human Flt3-Ligand is a soluble 17.6 kDa protein consisting of 155 amino acid residues.

Supplier: PeproTech, Inc.
Description: KGF (FGF-7) is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth, and the regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. KGF (FGF-7) is a mitogen factor specific for epithelial cells and keratinocytes. KGF/FGF-7 signals through FGFR 2b. KGF (FGF-7) plays a role in kidney and lung development, as well as in angiogenesis and wound healing. Recombinant Human KGF (FGF-7) is an 18.9 kDa protein consisting of 163 amino acid residues.

Supplier: PeproTech, Inc.
Description: FGF-16 is a heparin-binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development, postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-16 signals through FGFR 2c and 3c. FGF-16 plays a role in the development of the central nervous system. Recombinant Human FGF-16 is a 23.6 kDa protein consisting of 206 amino acid residues.

Supplier: PeproTech, Inc.
Description: TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins, and contain a cytoplasmic "death domain," which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane-anchored or soluble TRAIL/Apo2L. The DR4 and DR5 receptors are both produced as type I transmembrane proteins, which contain an extracellular domain, a transmembrane domain, and a cytoplasmic domain. The recombinant soluble forms of DR4 and DR5 consist of the TNFR-homologous, cysteine-rich portion of their respective extracellular domains. Recombinant Human sTRAIL Receptor-2 is a 14.9 kDa protein (133 amino acid residues) consisting of the TNFR-homologous, cysteine-rich portion of the extracellular domain.

Supplier: PeproTech, Inc.
Description: Produced from sera of goats immunized with highly pure Recombinant Human LEC (CCL16). Anti­Human LEC (CCL16)­specific antibody was purified by affinity chromatography employing an immobilized Human LEC matrix.

Supplier: PeproTech, Inc.
Description: Produced from sera of rabbits immunized with highly pure Recombinant Human TARC (CCL17). Anti­Human TARC (CCL17)­specific antibody was purified by affinity chromatography and then biotinylated.

Catalog Number: (10771-570)
Supplier: PeproTech, Inc.
Description: PeproTech's Murine Exodus-2 (CCL21) ELISA development kit contains the key components required for the quantitative measurement of natural and/or recombinant murine Exodus-2 (CCL21) in a sandwich ELISA format.


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Stock for this item is limited, but may be available in a warehouse close to you. Please make sure that you are logged in to the site so that available stock can be displayed. If the call is still displayed and you need assistance, please call us at 1-800-932-5000.
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